Cost-effectiveness of rotavirus vaccination in the Netherlands; the results of a consensus model

Rozenbaum, Mark H; Mangen, Marie-Josee J; Giaquinto, Carlo; Wilschut, Jan C; Hak, Eelko; Postma, Maarten J

doi:10.1186/1471-2458-11-462

BMC Public Health

Table 1 Parameters used in the economic model

From: Cost-effectiveness of rotavirus vaccination in the Netherlands; the results of a consensus model

Description	Base case value	Distribution	References
Vaccine Efficacy
Severe infections hospitalisation (first year)	0.945	Lognormal mean 0.945 (SE 0.014)	[21]
Waning rate per year (exponential decrease)	0	NA	[23]
Mild infections requiring an office visit (average first 2 years, see Methods)	0.874	Lognormal mean 0.874 (SE 0.052)	[24]
Waning rate per year (exponential decrease)	0.09	NA	Assumption
Mild infections treated at home (first year)	0.720	Lognormal mean 0.720 (SE 0.040)	[21]
Waning rate per year (exponential decrease)	0.18	NA	[21]
Incidence per million children (<5 years)
Total number of community-acquired RV cases	65,680	Normalised mean: 65,680 (90%CI; 43,890-90,945)^a	[9]
No medical help requested	52,947	Total number of cases minus total number of GP visits (calculated)
GP visits	12,733	Normalised mean: 12,733 (90%CI; 6,922-20,384)^a	[9]
Total hospitalisations	3600	Pert (2600; 3600; 4500)	[9]
Of which nosocomial infections	13%	NA	[16]
Deaths as% of total number of hospitalisations	0.02%	Triangular (0%; 0.02%; 0.12%)	[18]
Total QALY detriment
Rotavirus infection treated at home			[25, 26]
0-18 months	0.0015	See Methods section
18-59 months	0.0025
Rotavirus infection requiring medical attention (GP)			[25, 26]
0-18 months	0.0022
18-59 months	0.0031	See Methods section
Rotavirus infection requiring hospitalisation (including nosocomial)			[25, 26]
0-18 months	0.0036	See Methods section
18-59 months	0.0042
Total direct costs per case
Case treated at home (0-3 years)^b	4.25	Triangular (2.66; 4.25; 7.44)	[7]
Case requiring GP visit^b	70.08	Triangular (52.08; 70.08; 82.70)	[7, 28]
Case requiring hospitalisation	2146	Triangular (1933; 2146; 2359)	[7, 16, 42]
Case requiring hospitalisation (nosocomial)	1825	Triangular (1280; 1825; 2377)	[7]
Total indirect cost per case (care giver taking care of child)
Case treated at home	35.26	Triangular (31.74; 35.26; 38.79)	[28, 42]
Case requiring GP visit	51.09	Triangular (45.99; 51.09; 59.20)	[28, 42]
Case requiring hospitalisation^c	55.41	Triangular (49.87; 55.41; 60.95)	[28, 42]
Case requiring hospitalisation (nosocomial)	45.34	Triangular (40.80; 45.34; 49.87)	[28, 42]
Total cost per vaccinee	50, 75, 100	Triangular (50; 75; 100)	Assumption

NA, not applicable; SE, standard error
^a Square root transformation was applied.
^b Cost for older children were lower as diapers were not assumed to be used any more in children aged 3 years and older.
^c In the model indirect costs and QALYs are corrected for indirect costs and QALYs which have already occurred at the GP to avoid double counting (as we assumed that all hospitalised cases would already have visited a GP before being hospitalised).

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ISSN: 1471-2458

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