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Table 4 Tested parameters for the sensitivity analyses

From: Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

Parameters Base case Sensitivity analyses Source for the sensitivity analyses
Vaccine coverage rate 90% 50%/97% Ref 50
Ratio non seeking medical care/seeking medical care 70.65% 56.52%/84.78% ± 20%
Discount rates:    
For costs 3% 6%/0% Assumption
For benefits 3% 6%/0% Assumption
Incidences:    
PCC 2.19% 1.752%/2.628% ± 20%
Hospitalization 0.65% 0.52%/0.78% ± 20%
Emergency visits 1.89% 1.512%/2.268% ± 20%
Nosocomial infections 0.16% 0.128%/0.192% ± 20%
Vaccine efficacy in reduction of RVGE cases:    
PCC visits 86% 73.9%/92.5% 95% CI
Emergency visits 93.7% 88.8%/96.5% 95% CI
Hospitalization 95.8% 90.5%/98.2% 95% CI
Vaccine efficacy annual rate by year Constant decrease by year of 10% Exponential decrease after year 2. Assumption
Cost of the disease, NHS perspective:    
PCC visit 16.61€ 14.62€/18.63€ 95% CI
Emergency visit 204.29€ 186.19€/222.39€ 95% CI
Hospitalization among non vaccinated 1248.99€ 1110.35€/1386.38€ 95% CI
Nosocomial infection 744.00€ 706.80€/781.20€ 95% CI
Cost of the disease, societal perspective:    
PCC visit 165.89€ 110.81€/221.05€ 95% CI
Emergency visit 408.87€ 330.65€/486.96€ 95% CI
Hospitalization among non vaccinated 1551.70€ 1364.72€/1738.68€ 95% CI
Nosocomial infection 896.80€ 851.96€/941.64€ 95% CI