Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study

Schooling, CM; Jiang, CQ; Lam, TH; Cowling, BJ; Au Yeung, SL; Zhang, WS; Cheng, KK; Leung, GM

doi:10.1186/1471-2458-10-270

Table 3 Instrumental variable estimate (odds ratio) for the effect per birth weight standard deviation on cardiovascular disease risk factors in 18,958 older Chinese men and women in phases 2 and 3 of the Guangzhou Biobank Cohort Study (2005-8), overall and stratified by sex

From: Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study

	Proportion			All		Men		Women
	Men	Women	†Model	Odds ratio	95%CI	Odds ratio	95%CI	Odds ratio	95%CI	¶p
Raised blood pressure	55.9%	47.2%	1	0.93	0.91 to 0.96	0.93	0.88 to 0.99	0.94	0.91 to 0.97	0.82
(≥ 130/85 mmHg or appropriate medication)			2	0.93	0.91 to 0.96	0.93	0.88 to 0.99	0.93	0.90 to 0.97	0.88
			3	0.94	0.91 to 0.96	0.93	0.88 to 0.99	0.94	0.90 to 0.97	0.88
			4	0.94	0.91 to 0.97	0.93	0.87 to 0.98	0.94	0.91 to 0.97	0.66
Reduced HDL-C	15.2%	19.3%	1	0.98	0.94 to 1.01	1.00	0.93 to 1.08	0.97	0.93 to 1.01	0.43
(<1.03 mmol/L for men; <1.29 mmol/L for women; or appropriate medication)			2	0.98	0.94 to 1.02	1.00	0.93 to 1.09	0.97	0.93 to 1.01	0.45
			3	0.98	0.94 to 1.02	1.00	0.93 to 1.08	0.97	0.93 to 1.02	0.47
			4	0.98	0.95 to 1.02	0.99	0.92 to 1.08	0.98	0.94 to 1.02	0.69
Raised fasting plasma glucose	33.7%	31.4%	1	1.02	0.99 to 1.05	1.04	0.98 to 1.10	1.01	0.98 to 1.05	0.49
(≥ 5.6 mmol/L or appropriate medication)			2	1.02	0.99 to 1.05	1.04	0.98 to 1.10	1.01	0.97 to 1.05	0.45
			3	1.02	0.99 to 1.05	1.03	0.97 to 1.10	1.01	0.98 to 1.05	0.44
			4	1.02	0.99 to 1.06	1.03	0.97 to 1.10	1.02	0.98 to 1.06	0.67
Raised triglycerides	34.2%	35.5%	1	0.99	0.96 to 1.02	0.97	0.91 to 1.03	1.00	0.97 to 1.04	0.27
(>1.7 mmol/L)			2	0.99	0.96 to 1.02	0.97	0.91 to 1.03	1.01	0.97 to 1.04	0.26
			3	1.00	0.97 to 1.03	0.97	0.91 to 1.03	1.01	0.97 to 1.04	0.26
			4	1.00	0.97 to 1.03	0.96	0.90 to 1.02	1.02	0.98 to 1.06	0.10
Central obesity	17.2%	34.9%	1	0.98	0.95 to 1.01	1.05	0.98 to 1.13	0.96	0.93 to 1.00	0.04
(waist circumference ≥ 80 cm for women or ≥ 90 cm for men)			2	0.98	0.95 to 1.01	1.05	0.98 to 1.13	0.96	0.93 to 1.00	0.03
			3	0.99	0.96 to 1.02	1.06	0.98 to 1.14	0.97	0.94 to 1.01	0.04
*Metabolic syndrome	11.6%	20.7%	1	0.98	0.94 to 1.02	1.04	0.95 to 1.13	0.97	0.93 to 1.01	0.15
			2	0.98	0.94 to 1.02	1.04	0.96 to 1.14	0.97	0.93 to 1.01	0.14
			3	0.99	0.95 to 1.03	1.05	0.96 to 1.14	0.97	0.93 to 1.02	0.15

†Model 1 adjusted for study phase, age and where appropriate sex
Model 2 additionally adjusted for parental possessions and education
Model 3 additionally adjusted for number of offspring, leg length and seated height
Model 4 additionally adjusted for BMI and WHR
¶p value for interaction by sex
*Metabolic syndrome defined according to the criteria of the International Diabetes Federation: Waist circumference ≥ 80 cm in women or ≥ 90 cm in men, plus any two of the following 4 factors: 1) triglyceride level > 1.7 mmol/L; 2) HDL cholesterol level <1.03 mmol/L in men or <1.29 mmol/L in women or treatment for this specific abnormality; 3) systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg or treatment for hypertension; and 4) fasting plasma glucose level ≥ 5.6 mmol/L or previously diagnosed type 2 diabetes

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ISSN: 1471-2458

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