Hepatotoxicity and effectiveness of a Nevirapine-based antiretroviral therapy in HIV-infected patients with or without viral hepatitis B or C infection in Cameroon

Table 2 Adjusted risks of outcomes associated with the hepatitis coinfection*

Outcome	Ratio or coefficient	95% confidence interval	p
Hepatotoxicity
Grade ≥2^†	2.94	1.49-5.81	0.002
Grade ≥3^†	2.18	0.61-7.75	0.2
Highest grade^‡	1.83	1.28-2.60	0.001
CD4 cell count increase^\|\|
Primary slope	0.02	-0.20 to 0.24	0.9
Secondary slope^¶	-0.04	-0.38 to 0.31	0.8
Quadratic effect^¶	0.00	-0.00 to 0.01	0.8
Viral load < 400 copies/mL^†	1.00	0.68-1.47	0.9
Death^†	0.52	0.14-1.93	0.3
Death or new AIDS-defining event^†	0.37	0.11-1.29	0.1

* Coinfected patients versus monoinfected patients. ^† Cox regression. ^‡ Poisson regression. ^|| Mixed-effect linear regression of the square root-transformed CD4 cell count. ^¶ From 6 months to 24 months, combined with the primary slope.

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