Regulation of antibiotic sales in Mexico: an analysis of printed media coverage and stakeholder participation
© Dreser et al.; licensee BioMed Central Ltd. 2012
Received: 22 May 2012
Accepted: 26 November 2012
Published: 6 December 2012
Restricting antibiotics sales to those with medical prescriptions only is a central strategy for promoting appropriate use and containing antibiotic resistance; however, many low and middle income countries have not enforced policies that prevent widespread self-medication with antibiotics. In 2010, the Mexican government announced the enforcement of antibiotic sales regulations, a policy that gained media prominence. This study analyzes media coverage of issues, stakeholder representation, and positions taken during policy agenda setting, drafting, and implementation to shed light on policy making to promote appropriate antibiotic utilization.
We carried out a quantitative content analysis of 322 newspaper articles published between January 2009 and December 2010 in 18 national and regional newspapers. Additionally, we conducted a qualitative content analysis to understand the positions adopted and strategies developed by nine key stakeholders. Framing theory guided the analysis.
The Ministry of Health dominated media coverage, justifying the enforcement policy by focusing on risks of self-medication, and to a lesser degree dangers of increasing antibiotic resistance. Pharmacy associations appeared to be the leading opponents, arguing that the policy created logistical difficulties and corruption, and had negative economic impact for pharmacies and their clients. The associations developed strategies against the regulation such as attempting to delay implementation and installing physicians’ consultation offices within pharmacies. While medical associations and academic institutions called for a comprehensive strategy to combat antibiotic resistance, improve prescription quality, and create public awareness, these issues had little impact on media coverage. Consumer groups and legislators received very little media coverage.
The narrowly-focused and polarized media coverage ─centred on problems of self- medication and economic impact ─ was a missed opportunity to publicly discuss and to develop a comprehensive national strategy on antibiotic use in Mexico. It highlights the need for discussing and developing interventions within the framework of a pharmaceutical policy.
KeywordsAntibiotics Mexico Over-the-counter sales Antibiotic resistance Media analysis Pharmaceutical policy
Aiming to address the global public health threat caused by antimicrobial resistance, the World Health Assembly in 1998 urged member countries to promote the appropriate use of antimicrobials by improving prescribing, dispensing, surveillance and legislation . In the same year, the Pan American Conference on Antimicrobial Resistance in the Americas recommended that countries improve antibiotic use, including restriction on antibiotic sales to prescription-only and education on the proper use of antibiotics for health professionals and community members . In 2001, the World Health Organization (WHO) launched its Global Strategy for Containment of Antimicrobial Resistance. Recognizing that isolated interventions have little impact on improving antibiotic use, the Global Strategy proposed a range of interventions, organized under the umbrella of national health and medicine policies . These recommendations were updated in 2011 .
Only a few, largely high-income, countries have developed national strategies to promote appropriate antibiotic use; many countries have had difficulty translating international recommendations into national action plans. In part, difficulties have resulted from multiple stakeholder coordination, rigid legal frameworks, and potential conflicts between guaranteeing access to medicines and assuring rational use [5, 6].
Antibiotic policies in Mexico
Mexico is a middle-income country characterized by a fragmented health care system; expenditure in medicines occurs largely as out-of-pocket . Until recently, antibiotics were among medicines most commonly sold in private pharmacies (approximately 40% without prescription) , and their use for many years exceeded that of other Latin American countries . Inappropriate antibiotic prescriptions and lack of enforcement of prescription-only sales of antibiotics are both well-documented problems that Mexico shared with other Latin American countries [8, 10]. Inappropriate antibiotic use and resistance have been very low on the government’s policy agenda, partly due to the lack of clear problem indicators, ignorance of strategies promoted internationally, and perception by policy makers that access to and supply of medicines should receive priority . A White Paper by the Mexican Ministry of Health (MOH) proposing a National Pharmaceutical Policy in 2005 argued that regulating medicines sales to prescription-only by physicians – as stipulated by law since 1984 – had not been enforced as a measure to promote access to medicines because universal health care coverage has not been achieved .
In March 2010, the Mexican National Health Council announced a new policy enforcing the prescription-only status for antibiotic sales. It created an unprecedented public debate that gained prominence and space in the media. The announcement followed a declaration by the Minister of Health in May 2009 − in the midst of the H1N1 influenza outbreak − associating high mortality amongst influenza patients with self-medication, particularly with antibiotics . The policy, enacted as a Ministerial Agreement, additionally required all antibiotic prescriptions to be retained and registered in pharmacies, and imposed high penalties for non-compliance, including rescinding business licenses. Soon after the announcement, the policy was opened to public discussion in a governmental website. Although several actors from the private sector declared opposition to the policy, it was finally approved with only minor changes, one of them delaying implementation for some months. The enforcement policy applied to 2,000 medicines – roughly one fifth of all medicines available commercially in the country. Drafting and implementing actions to enforce regulations on antibiotic sales were accompanied by press round-ups and press bulletins organized by diverse stakeholders, opinion columns in newspapers, discussion forums on the internet, and special programmes on radio and television. This paper analyzes media coverage of that policy process.
Relevance of media coverage and interest group participation in the policy process
It has been recognized that the media not only have the potential to diffuse health information in society and to influence health behavior and attitudes [13, 14], but also have the potential to influence public perceptions of health policy issues, the political elite’s policy considerations, and, eventually, the final policy product [15, 16]. The media’s primary role in public policy making has been related to the process of agenda setting, through the ability to raise and shape issues and public opinion which, in turn, can impel governments to act . The way in which issues are discussed in the media influences how problems are defined and, consequently, which policy alternatives are considered to address them. One manner in which the media can shape public opinion of health policy issues is by framing or emphasizing them in particular ways . Although there is no consistency in how “framing” is referred to in the literature, a frame can be considered an emphasis on particular aspects of a topic . Entman  defines framing as follows: “[to] frame is to select some aspects of a perceived reality and make them more salient in a communicating text in such a way as to promote a particular problem definition, causal interpretation, moral evaluation, and/or treatment recommendation.” Policy issues reported in the media depend on which facts are reported and which frames are chosen to address them. The choice of frame reflects journalistic conventions; the interaction among journalists and elite constituents, social movements, and scientific bodies; as well as a frame’s resonance with broader political values [19, 21, 22]. De Vreese  proposed distinguishing between “issue specific” frames and “generic” frames which are not related to a specific topic or a specific cultural or historical context. Actors use diverse frames to draw attention to issues of concern implying that certain types of solutions are called for . Elite stakeholders have significant resources for shaping journalistic frames to serve their specific interests , which include reinforcing the status quo. However, the media can also give voice to less powerful stakeholders in order to reflect dissension or give a new direction to a policy debate. As Entman  explains, frames reveal the “imprint of power” when reflecting the identity of actors and interests competing to dominate news texts. Because framing emphasizes one aspect of a problem at the expense of others, it can restrict public debate on policies in the range of issues and policy alternatives considered [15, 23].
The objective of this study was to analyze media coverage of the process that led to the enforcement policy on antibiotic sales regulations in Mexico focusing, firstly, on 1) Which themes gained more or less prominence; 2) Which stakeholder groups dominated the public debate; 3) What were their positions and actions vis-a-vis the enforcement policy. The results are discussed in relation to the processes of agenda setting, policy drafting, and policy implementation in order to highlight potential media and stakeholder effects on the overall development process. Secondly, with this study we aimed to shed light on the process of policy making for medicines in Mexico that could be relevant for other low and middle income countries (LMICs) wishing to develop policies directed at improving the use of antibiotics.
Data sources and collection
Newspapers searched and number of articles included in the analysis
Estimated number of copies sold per day
Number of articles included in the analysis
El Sol de México
Diario de México
Uno más uno
La Crónica de Hoy
Rumbo de México
Total number of articles
Summary of the codebook
Description of the category and subcategories included
Purchase and use of prescription-only-medicines, including antibiotics, without medical prescription. Subcategories: i) SM to treat viral infections (influenza, other respiratory or gastro-intestinal infections); ii) causes and scope of SM; iii) solutions to the problem of SM, including the new policy to enforce sales regulation.
Antibiotic resistance (AR)
Antimicrobial or antibiotic resistance. Subcategories: i) causes and scope, including relation to self-medication and prescription ii) solutions, ii) using AR as an argument to support the new policy to enforce regulation on antibiotic sales.
Medical PM of antibiotics. Subcategories: i) unjustified PM of antibiotics (for instance, for influenza and other respiratory diseases) ii) perception of low quality of PM; iii) need to train physicians and improve their PM of antibiotics
Economic impact (EI)
Direct and indirect EI resulting from the enforcement policy. Subcategories: i) EI in the private sector such as pharmacies and the pharmaceutical industry; ii) EI in the population.
Corruption in the pharmaceutical sector derived from the enforcement policy. Subcategories: i) Black market of counterfeit medicines; ii) Black market of prescriptions; iii) CO in the process of pharmacy supervision; iv) physicians involved in CO.
Regulation and policies related to the sales of antibiotics in Mexico. Subcategories: i) Legislative framework and lack of enforcement; ii) processes of drafting and implementing the enforcement policy; iii) need to develop an impact evaluation of the enforcement policy; iv) objective of the enforcement policy; v) need to disseminate information about the enforcement policy.
Health System (HS)
Functioning of the Mexican health system in relation to antibiotic use or the enforcement policy. Subcategories: i) problems of the HS; ii) impact of the enforcement policy on the health services provided in the HS; iii) access to health services for the population without health insurance.
Rational use of medicines (RUM)
Rational use of medicines in the national and international context. Subcategories: i) International guidelines on RUM; ii) recommendations to achieve RUM in Mexico; iii) causes and consequences of inappropriate use of antibiotics, including adverse reactions (but excluding references related solely to self-medication).
Functioning of pharmacies in relation to antibiotic use or the enforcement policy. Subcategories: i) Operation of PH, ii) quality of services provided by pharmacy staff, and training of pharmacy staff; iii) position of pharmacy associations towards the enforcement policy; iv) demand of the pharmacy associations owners towards the government.
For the quantitative content analysis, we first calculated the frequency of thematic categories for each of the three time periods separately. If a thematic code was mentioned several times in the same article, we counted it only once. Secondly, stakeholder appearance was counted as the number of times a stakeholder was mentioned in a newspaper article: the same association or institution was counted only once per article even if it was mentioned several times in the same article. We counted separately different actors in the same stakeholder group mentioned in the same articles.
In order to understand the position and actions of stakeholders in relation to the new policy during each stage of the policy making process, a qualitative content analysis was performed of all the notes in which a stakeholder code appeared. Firstly, we concentrated the analysis on the voice of stakeholders, particularly quotes, rather than the voice of journalists (except for editorials and opinion columns for which we considered journalists as another stakeholder group). Here, we looked for statements about the policy and its objectives, and for arguments against or supporting the new policy. Secondly, we looked, both in the voice of stakeholders and journalists, for references to specific actions developed by the actors in relation to the new policy development. During the analysis, we searched for similarities and differences between actors within the same stakeholder group, and between different stakeholder groups.
Topics covered by the news media
Agenda setting: "Self-medication" was the most frequent thematic category, particularly the risks of inappropriate treatment of respiratory diseases, including H1N1 influenza, with antibiotics. The second most frequently mentioned thematic category was “regulation,” with most of the discussion focusing on the lack of enforcement for antibiotic sales. The third category, “antibiotic resistance,” was covered mainly as a consequence of self-medication. The need to promote the rational use of antibiotics – including improving medical prescribing – was also addressed during this stage.
Policy drafting: “Regulation” was the main thematic category during this phase, and included sub-categories such as the process of policy development (a third of the notes were coded in this category) and the objective of the enforcement. “Self-medication” and “antibiotic resistance” were frequently mentioned in relation to each other; both were used as arguments to support the new policy. The thematic category “pharmacy” was mentioned more frequently in relation to the role of pharmacies in implementing the policy, and to the demands made by the pharmacies to the government. The “economic impact” of the policy emerged as a theme: almost two-thirds of the notes mentioned the economic impact on the retail sector, while less than half referred to the economic impact on the population. “Corruption” was mentioned in relation to the risks of prescription falsification and counterfeit antibiotics subsequent to the policy.
Policy implementation: During this period, the theme “regulation” also dominated media coverage, but in relation to information and impact of the policy. Increasing media coverage included the categories “economic impact” on the retail sector, “corruption,” and “pharmacy”. The category “health system” also gained relevance, with most of the notes covering the impact of the enforcement on the health system and the inability of health system capacity to provide health care to the population. In contrast, discussions about the rational use of medicines became less prominent.
Stakeholders covered by the media
Stakeholder positions and strategies
Ministry of health
The MOH, as the main supporter of the policy, focused initially on the dangers of self-medication, especially in relation to influenza, as the main justification for the policy. Among the first declarations published were: “No more self-medication damaging the Mexicans” ; “… the use of antibiotics in cases of influenza H1N1 has been fatal […]” . Later, the problem of antimicrobial resistance was also mentioned, linking it only to self-medication; as the Health Minister explained: “The regulation is not a caprice. In Mexico, the population is generating a resistance to antibiotics which arises from self-medication” .
When faced with arguments by other actors against the policy and the demand to delay its implementation, the MOH defended the enforcement arguing that access to medical care was guaranteed with “Seguro Popular,” a recently-introduced form of health insurance. Even the Mexican President was quoted supporting the policy . Later, the MOH recognized the arguments regarding counterfeit prescriptions and the lack of an information campaign, declaring that they would be addressed. Arguments that could have been used to gain support for the policy, such as protecting against adverse drug reactions and unnecessary expenses, were scarcely addressed.
When, because of policy implementation, physician consultation offices attached to pharmacies began to emerge, the position of the MOH was portrayed as vague, and only some statements cautioned the population about the quality of these consultations. In contrast, the MOH stressed the “positive” impact of the policy, declaring that a 35% reduction in antibiotic sales had been achieved .
Pharmacies and outlet associations
The position of these groups – as portrayed by the media – was predominantly against the enforcement policy. Even though initial statements were generally favourable (recognizing the problems of self-medication and antibiotic resistance), later these groups appeared as leading opponents. Main arguments conveyed were economic losses and logistical difficulties for the pharmacies (now forced to pursue additional tasks when selling antibiotics) as well as the negative health and economic effects particularly on poor populations with scarce access to healthcare. Other arguments were that the regulation would foster corruption, namely a black market in antibiotics and counterfeit prescriptions, as well as false inspectors blackmailing pharmacies.
Early strategies used against the policy included creating alliances (among some independent pharmacy associations, medicine distributors and outlet associations) demanding the government delay implementation in order to develop first a detailed impact assessment. Later they demanded a public education campaign (to change the “culture of self-medication”) and the provision of information systems for pharmacies to facilitate the new dispensing procedures. The association of independent pharmacies ANAFARMEX asked the government to stop the “witch hunt” against them and demanded the provision of loans to modernize small pharmacies, as well as the publication of a comprehensive database of all registered physicians in Mexico to detect false prescriptions. Another association (UNEFARM) organized a protest at the regulatory agency building against the regulation and sent a petition to the President. In contrast, declarations by large pharmacy chains were very scarce.
During the implementation period, ANAFARMEX demanded that the government permit sales of analgesics and cold and cough preparations only in pharmacies (and not in other outlets) as a way of compensating for economic loss. A later strategy developed by large pharmacy chains buffered the impact of the regulation by offering a “discount” on antibiotics, and creating physician offices attached to pharmacies to offer cheap or free medical consultation. Independent pharmacy associations pointed out that these “express clinics” generated unfair competition for smaller pharmacies. Six months after the implementation, four pharmacy chains plus some independent pharmacies had included consultation offices within drugstores; one large pharmacy chain declared that each of its 920 branches had physicians who offered free “medical counseling” for over 30,000 consumers each day .
Medical professional associations and academic institutions
According to the media, these stakeholders were predominantly in favor of the policy, highlighting antimicrobial resistance and adverse drug reactions as serious public health problems. At the same time, they stressed the need for an integrated action plan to improve medical prescribing, increase public awareness regarding the prudent use of antibiotics, and professionalize pharmacies. Some medical associations mentioned concerns about limited access to antibiotic prescriptions in poor rural communities and the quality of care offered in clinics attached to pharmacies.
During the policy drafting period, the action taken by these groups included the publication of open letters to the MOH and dissemination of a policy brief suggesting priority actions. Excerpts of the policy brief were later incorporated into the declarations of the MOH and in the official publication of the Ministerial Agreement.
Congress ─the Mexican legislative body─ declarations were scarcely mentioned in the media during the initial phase and reflected divided positions by political parties. While legislators of the ruling political party were supportive of the policy, members of opposing parties stressed the adverse health and economic impact on the population (now “forced to pay a doctor”) given the insufficient availability and quality of public health services. Some legislators in the Congress tried to promote an agreement to revoke the policy, arguing that it was “a restrictive measure that did not correspond with a health policy for a country facing a political, economic and social crisis” . Strategies of the Congress to intervene included the proposal of a law reform to introduce higher punishments for those who use false prescriptions, and demands to the executive branch of the government to develop information campaigns and an independent evaluation of the policy impact.
Pharmaceutical industry and other private firms
During the early policy stages, media coverage addressed the declarations by some national pharmaceutical companies regarding administrative uncertainty around the policy change, as well as demanding the government develop an impact assessment and delay implementation. The generic medicines industry underlined the importance of prescribing antibiotics by generic name.
The statements by transnational pharmaceutical companies and consulting agencies were more frequent during the implementation period and focused on the high value of the antibiotic market in Mexico, the resultant “reconfiguration of the market,” the economic losses that the pharmaceutical sector would face and the need to reinvent the pharmacies. Deloitte, a private consulting agency, suggested that among the new business models to avoid economic drawbacks for pharmacies were the “in-situ physicians” . They also warned that other regulations to control sales of other medicines could be expected. Except for one company, these groups omitted the issue of antimicrobial resistance.
Patients and civil society groups
There were only a few declarations by patients and civil society organizations. Although the media reflected the views of citizens (in letters to the editors, interviews to the population, and on-line discussion forums), the declarations of only one association (“El poder del consumidor”) were reflected in the media. This association underlined the possible negative effect of the enforcement policy for the poorest populations and stressed the need to improve access to health care, provide the public with more information and monitor user fees for private medical services.
During the formulation period, several editorials and columns discussed the appropriateness of the regulation in recognizing the conflict between the problems of self-medication and antimicrobial resistance on one side, and the problem of low access to and low quality of public medical services (including long waiting times and medicines stock outs) on the other. Some columns questioned the real reasons for the regulation. Interestingly, many editorials were also critical about the lack of transparency and clear leadership in the process of policy making. Some editorials also questioned the feasibility of implementing the regulation in a country inundated by medicines promotion, where traditionally the law is not enforced, and there are too few inspectors to supervise the pharmaceutical sector.
The results highlight a number of important points about media coverage and stakeholder participation in relation to antibiotic use and the process of regulating antibiotic sales in Mexico that could be relevant for other LMICs aiming to develop policies directed to improving the use of medicines.
Even though the theme of regulation dominated media coverage, the focus was primarily on the problems of developing the policy, and little, except for self-medication, about its objectives or its relation to public health issues. The other dominant themes in media debates mirrored the voice of the two major stakeholders involved. On one hand, the MOH defended the policy by citing the dangers of self-medication with antibiotics; on the other, pharmacy associations opposed it, citing issues of economic impact and corruption. These divergent frames were scarcely addressed by the media on the common ground of a wider public debate on rational use of medicines and pharmaceutical policy. The emphasis on the problem of self-medication probably minimized public concerns about new physician offices attached to pharmacies and contributed to the belief that, with the policy, problems in antibiotic use had been solved. This represented a missed opportunity to discuss in-depth pharmaceutical policies and the development of a national strategy on antibiotic use. Additionally, media coverage also represented a missed opportunity to sensitize the public about the problem of antibiotic resistance and the need to use antibiotics prudently, which coincides with other studies which stress the scarcity of key mobilising information on health directed to the public .
Besides the interests and resources of stakeholders, the predominant themes reflected in news coverage of antibiotic use and antibiotic regulation can also be explained by journalistic conventions. These conventions tend to favour certain generic frames such as “episodic framing”  in which social issues and public affairs are portrayed as limited to events only, and not discussed in a broader context (e.g. coverage centred on the policy enactment, rather than in the problem of antibiotic use). Other common generic frames found in our study are “conflict” (winners and losers, corruption) and “economic consequences”. Coverage might also be explained by a regional trend characteristic of Latin America of health news reporting leaning towards frames of political conflict .
The present study also sheds light on the actors and processes involved in health and pharmaceutical policy making in Mexico. The executive government, mainly the MOH and the medicines regulatory authority dominated media coverage. This agrees with studies portraying the process of public policy making in Mexico as state-centered, with low levels of pluralistic debate . The scant involvement of the legislature and the fact that coverage reflected contradictory views of individual legislators instead of that of an ad-hoc expert commission also coincides with other studies highlighting the traditionally weak role of the legislature and its advisory commissions in decision-making [36, 37].
The associations of small independent pharmacies mostly affected by the regulation were successful in organizing press round-ups to push their views in media debates and make specific demands to the government. These groups also took advantage of this momentum to advance their own agenda, such as the threat of competition by pharmacy chains. This coincides with other authors pointing out that, although Mexico has attained a media establishment relatively independent of government control, it has also been increasingly beholden to commercial interests [38, 39]. However, even when these association groups had a strong voice, their effect appears to be limited, suggesting that the influence of political factors may outweigh media framing effects on shaping policies, as other studies have pointed up .
Large pharmacy chains had a minor presence in media debates, as did the transnational pharmaceutical companies because their interests might not be greatly affected by the policy. Some large chains buffered the impact of the policy by opening new physician offices, which might have favored the prescription of branded medicines. Private enterprises largely framed the policy debate as a business issue, rather than a health issue, which resulted in a focus on maximizing profits rather than improving medicines use. This highlights the inherent complexities of pharmaceutical policies competing with both economic and public health interests.
Academic institutions and medical associations also took advantage of the policy momentum to push their own agendas, especially during the agenda setting and the early drafting periods. They used the media to stress the need to develop a comprehensive strategy on antibiotic use, a theme that had little resonance in the media, and had little impact on the final policy.
The scarcity of newspaper coverage describing dialogue or interaction between interest groups and the MOH, and the lack of governmental response to the demands of interest groups (such as developing a public information campaign), reflect a political context characterized by vertical and closed decision-making. In addition, remarks in the media and editorials speculating about the true reasons for the enforcement suggest a lack of transparency and lack of trust in the authorities.
Traditionally, civil society has had a very marginal role in decision-making in Mexico [36, 37] with the voice of these actors barely present in media coverage. The absence of opinions by pharmacist associations can be explained by the small number of pharmacists working in private sector pharmacies. The large majority of pharmacy staff lack university degrees and undergo very little professional training in pharmaceutical sciences or related areas . Hence, pharmacy associations with a business focus rather than professional associations emphasizing professional credentials dominated the media debate.
Our results coincide largely with the findings of an analysis of printed media coverage of tobacco policies in Mexico  which reported the overwhelming presence of governmental actors, and limited inclusion of academic centers and civil society organizations. However, because the tobacco study included coverage of the development of two laws, the presence of actors from the legislative branch was significantly larger. Interestingly, our results on actor participation contrast sharply with a similar study on medicines policy developed in Canada  where civil society was the dominant voice, demonstrating the strategic use of the media by these groups. Although Mexico is undergoing a democratic transition, the experience of media advocacy by academic and civil society groups is still developing.
Some lessons can be drawn from our study which are relevant for other low and middle-income countries aiming to develop policies directed at improving antibiotic use. First, active opposition by some stakeholders to the enforcement of regulations on antibiotic sales should be expected, particularly arguing the economic impact on the population. Actions seeking to counteract the policy goals include opening physician offices next to pharmacies. Second, even if the voices of governmental and business-related groups are favored in media coverage, the policy views of other groups can also achieve visibility in the media which could contribute to a more informed policy development process. Third, this study showed that even if governmental action focuses on a single problem and a single intervention (enforcement of sales regulations to avoid self-medication), other related issues will soon arise in public debate. These issues include access to medicines (a very sensitive issue for the population), the quality of medical services, the tracking of prescriptions and verification of their authenticity, and the adverse impact on commercial interests. These concerns highlight the need to discuss and develop interventions within the common framework of a pharmaceutical policy, and to engage stakeholders during the policy process. Finally, the scarcity of in-depth reporting on issues of antibiotic use and regulation in Mexico and Latin America has also been related to the limited availability of specialized journalism and independent information sources . To address these limitations and to generate political priorities on antimicrobial use and resistance, the South American Infectious Disease Initiative  has worked with the news media in three countries, resulting in an improvement on the quantity and quality of coverage of these issues , an experience that might be worth replicating in other countries.
How does the Mexican case compare with other relevant experiences? The cases of India and Brazil, both middle-income countries that undertook antibiotic policies contemporaneously to Mexico are worth discussing. During 2010, international attention turned to the spread of the New Delhi metallo-beta-lactamase 1 (NDM-1) gene, believed to have originated in India, which causes several types of bacteria to become resistant. The naming of the gene and a description of its spread from that country to Europe in an influential international medical journal was followed by an intense public debate in India . Controversy triggered action and, in 2011, the Indian government published the National Policy for Containment of Antimicrobial Resistance. The policy included, among many other interventions, the banning of over-the-counter antibiotic sales. However, later the government decided to put this regulation on hold indefinitely, arguing concerns over access to medicines, particularly in rural areas . In the case of Brazil it was the spread of the multi-resistant bacterium CRKP (Carbapenem-Resistant Klebsiella pneumoniae), also followed by the media, which gave place to the resolution RDC 44/2010 of the Brazilian regulatory agency, regulating antibiotic sales to medical prescription only, to be retained at pharmacies. The resolution, supported by medical groups, faced the opposition of pharmacy associations, citing scarce access to medical services for the poorest populations, as well as the risk of triggering a parallel antibiotic market . Taken together, the cases of these three countries underline the relevance of focusing events (influenza outbreak, NDM-1 and CRKP spread) to place issues of antibiotic use and resistance on the governmental agenda. However, these cases also show that an apparently technical issue (regulating antibiotic sales) can be very politically sensitive – because economic interests are affected and because of the relation to wider complex societal issues – underlying again the need to discuss antibiotic policies within the common framework of a pharmaceutical policy, and to mobilize political support.
Our study presents some limitations. First, our analysis used a unique coding scheme (“issue-specific” instead of “generic” frames) which limits our ability to generalize and compare the results . However, whenever possible, we discussed our coding scheme in relation to generic frames. Other limitations concern excluding an analysis of electronic media (radio, television and internet) which are important in Mexico and other countries in the region  as well as the fact that our analysis was limited to the period of only five months after policy implementation. Relevant discussions and stakeholder actions that might have appeared later in the policy process or in other media outlets were excluded. Finally, as others pointed out, we can describe the representation of issues and stakeholder participation in the media, but we can only infer their potential effects on the public and on the policy process . To provide a more comprehensive picture of stakeholder participation in the policy process it is necessary to use alternative data sources.
Aspects of greater salience on media coverage were the issue of self medication used to justify the policy to enforce antibiotic sales regulations, and the negative aspects (economic impact and corruption) which largely represented the views of the two main stakeholders in the debate. Neither of these perspectives was conducive to public discussion on the wider problems of antibiotic misuse and resistance. Because framing emphasizes some aspects of the issues at the expense of others, the extensive coverage of the conflicts around developing and implementing the enforcement policy left little room to discuss wider societal issues, with the exception of discussions concerning access to medicines and health services. The absence of debate on the relationship between the policy and promoting rational use of medicines, improving the quality of services provided in pharmacies, and addressing the global public health threat posed by antimicrobial resistance meant a missed opportunity for discussing and developing a comprehensive national strategy on antibiotic use in Mexico.
We would like to thank Ann Payson for her support in editing the manuscript.
- World Health Organization: Emerging and other communicable diseases: Antimicrobial resistance. Resolution WHO51.17 51st. 1998, Geneva: World Health AssemblyGoogle Scholar
- Pan American Health Organization: Prevention and control of antimicrobial resistance in the Americas. 1999, Washington: Pan American Health OrganizationGoogle Scholar
- World Health Organization: Global strategy for containment of antimicrobial resistance. 2001, Geneva: World Health OrganizationGoogle Scholar
- Leung E, Weil DE, Raviglione M, Nakatani H, on behalf of the World Health Organization World Health Day Antimicrobial Resistance Technical Working Group: The WHO policy package to combat antimicrobial resistance. Bull World Health Organ. 2011, 89: 390-392. 10.2471/BLT.11.088435.View ArticlePubMedPubMed CentralGoogle Scholar
- Smith RD, Coast J: Antimicrobial resistance: a global response. Bull World Health Organ. 2002, 80: 126-133.PubMedPubMed CentralGoogle Scholar
- Dreser A, Wirtz VJ, Corbett KK, Anderson S: Inappropriate Antibiotic use and the Health Policy Agenda in Mexico [Abstract]. https://wfpha.confex.com/wfpha/2009/webprogram/Paper6033.html,
- Wirtz VJ, Santa Ana-Tellez Y, Servan Mori E, Avila-Burgos L: Heterogeneous effects of health insurance on out-of-pocket expenditure on medicines in Mexico. Value Health. 2012, 15: 593-603. 10.1016/j.jval.2012.01.006.View ArticlePubMedGoogle Scholar
- Dreser A, Wirtz VJ, Corbett KK, Echániz G: Antibiotic use in Mexico: review of problems and policies. Salud Publica de Mexico. 2008, 50 (Suppl 4): S480-S487.View ArticlePubMedGoogle Scholar
- Wirtz VJ, Dreser A, Gonzales R: Trends in antibiotic utilization in eight Latin American countries, 1997–2007. Panamerican Health Organization J. 2010, 27: 219-225.Google Scholar
- Sosa A, Travers K: Physician antibiotic prescribing practices and knowledge in seven countries in Latin America and the Caribbean: PAHO/APUA Report. 2002, Boston: Alliance for the Prudent Use of AntibioticsGoogle Scholar
- Secretaría de Salud: [Towards a comprehensive pharmaceutical policy for Mexico]. 2005, Mexico: Secretaría de SaludGoogle Scholar
- Secretaría de Salud: http://www.presidencia.gob.mx/2009/05/conferencia-de-prensa-que-ofrecieron-jose-angel-cordova-villalobos-secretario-de-salud-maki-esther-ortiz-dominguez-subsecretaria-de-innovacion-y-calidad-de-la-secretaria-de-salud-y-directora-general-d/,
- Prosser H: Marvelous medicines and dangerous drugs: the representation of prescription medicine in the UK newsprint media. Public Underst Sci. 2010, 19: 52-10.1177/0963662508094100.View ArticlePubMedGoogle Scholar
- Goulden R, Corker E, Evans-Lacko S, Rose D, Thornicroft G, Henderson C: Newspaper coverage of mental illness in the UK, 1992-2008. BMC Public Health. 2011, 11: 796-10.1186/1471-2458-11-796.View ArticlePubMedPubMed CentralGoogle Scholar
- Esmail LC, Phillips K, Kuek V, Cosio AP, Kohler JC: Framing access to medicines in developing countries: an analysis of media coverage of Canada’s Access to Medicines Regime. BMC Int Health and Human Rights. 2010, 10: 1-10.1186/1472-698X-10-1.View ArticleGoogle Scholar
- Wallack LM, Themba-Nixon M, Dorfman L, Jernigan D: Media Advocacy and Public Health: Power for prevention. 1993, London: SageGoogle Scholar
- Buse K, Mays N, Walt G: Making Health Policy. 2005, Berkshire: Open University PressGoogle Scholar
- Leask J, Hooker C, King C: Media coverage of health issues and how to work more effectively with journalists: a qualitative study. BMC Public Heal. 2010, 10: 535-10.1186/1471-2458-10-535.View ArticleGoogle Scholar
- De Vreese CH: News framing: Theory and typology. Information Design J Document Design. 2005, 13: 51-62. 10.1075/idjdd.13.1.06vre.View ArticleGoogle Scholar
- Entman RB: Framing: Toward clarification of a fractured paradigm. J COMMUN. 1993, 43: 51-58. 10.1111/j.1460-2466.1993.tb01304.x.View ArticleGoogle Scholar
- Carragee KM, Roefs W: The Neglect of Power in Recent Framing Research. J COMMUN. 2004, 54: 214-233. 10.1111/j.1460-2466.2004.tb02625.x.View ArticleGoogle Scholar
- Nerlich B: The antibiotic apocalypse’ and the ‘war’ on superbugs: The risks and benefits of catastrophe discourse. 2008, Nottingham: University of NottinghamGoogle Scholar
- Schon DA, Rein M: Frame reflection: toward the resolution of intractable policy controversies. 1994, New York: Basic BooksGoogle Scholar
- Especialistas en Medios: http://www.emedios.com.mx/canifarma/,
- Hsieh H, Shannon SE: Three approaches to qualitative content analysis. QUAL HEALTH RES. 2005, 15: 1277-1288. 10.1177/1049732305276687.View ArticlePubMedGoogle Scholar
- El Gráfico: Antibiotics only with prescription. El Gráfico. 2010, 10a:Google Scholar
- Toribio L: [Announcing sales of antibiotics only with prescription]. Excélsior. 2010, 22c:Google Scholar
- Vázquez L: [Decree to sell antibiotics only with prescription]. El Financiero. 2010, 31d:Google Scholar
- Tellez JA: [Medicines warning labels announced by industry]. Diario de México. 2010, 3c-d-Google Scholar
- Valadez B: Cordova: 35% less self-medication. Milenio. 2010, 5a:Google Scholar
- CNNExpansion: http://m2.cnnexpansion.com/expansion/2011/03/15/receta-de-negocio-para-curar-farmacias&completo=1,
- Mayen V: [Asking to stop restrictions to sale antibiotics]. Rumbo de Mexico. 2010, 3d:Google Scholar
- Ponce K: [Given the obligation to request a prescription: pharmacies, the industry that should reinvent themselves]. La Razón. 2010, 18a-d-Google Scholar
- Hilton S, Hunt K: Coverage of Jade Goody’s cervical cancer in UK newspapers: a missed opportunity for health promotion?. BMC PUBLIC HEAL. 2010, 10: 368-10.1186/1471-2458-10-368.View ArticleGoogle Scholar
- Waisbord S: When health is the headline: Dengue fever, AH1N1 flu and media-epidemic cycles. Folios. 2010, 23: 93-104.Google Scholar
- Cabrero-Mendoza E: Usos y costumbres en la hechura de las políticas públicas en México Límites de las policy sciences en contextos cultural y políticamente diferentes. Gestión y política pública. 2000, 9: 180-229.Google Scholar
- Trostle J, Bronfman M, Langer A: How do researchers influence decision-makers? Case studies of Mexican policies. HEALTH POLICY PLANN. 1999, 14: 103-14. 10.1093/heapol/14.2.103.View ArticleGoogle Scholar
- Lawson CH: Building the fourth estate: Democratization and the Rise of a Free Press in Mexico. 2002, Berkeley: University of California PressGoogle Scholar
- Sánchez M, Sivaraman S: News media reporting of antimicrobial resistance in Latin America and India. Antimicrobial resistance in developing countries. Edited by: Sosa A, Byarugaba DK, Amábile-Cuevas CF, Hsueh PR, Kariuki S, Okeke IN. 2010, New York: Springer, 525-537.View ArticleGoogle Scholar
- Wirtz VJ, Leyva-Flores R, Dreser A, Corbett KK: Organización y funcionamiento de las farmacias en México. Las farmacias, los farmacéuticos y el uso adecuado de medicamentos en América Latina. Edited by: Homedes N, Ugalde A. 2011, Buenos Aires: Lugar Editorial, 59-81.Google Scholar
- Llaguno-Aguilar SE, Dorantes-Alonso AC, Thrasher JF, Villalobos V, Besley JC: Analysis of coverage of the tobacco issue in Mexican print media. Salud Pública de Mexico. 2008, 50 (Suppl 3): S348-S354.View ArticlePubMedGoogle Scholar
- South American Infectious Disease Initiative. http://www.usaidsaidi.org/,
- Shetty P: End complacency on drug resistance. http://www.scidev.net/en/health/antibiotic-resistance/opinions/biomed-analysis-end-complacency-on-drug-resistance-1.html,
- Daily News and Analysis. http://www.dnaindia.com/health/report_govt-holds-antibiotic-policy-not-to-restrict-access-to-drugs_1594660,
- Jornal na Net. http://www.jornalnanet.com.br/noticias/1698/entidades-dizem-que-novas-regras-para-antibioticos-restringem-o-acesso-da-populacao-a-saude,
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/12/1051/prepub
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