Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination - United States, 2001-2010
© Berger et al; licensee BioMed Central Ltd. 2011
Received: 31 October 2010
Accepted: 19 May 2011
Published: 19 May 2011
Congenital rubella syndrome (CRS) is associated with several negative outcomes, including autism spectrum disorders (ASDs). The objective of this study was to estimate the numbers of CRS and ASD cases prevented by rubella vaccination in the United States from 2001 through 2010.
Prevention estimates were calculated through simple mathematical modeling, with values of model parameters determined from published literature. Model parameters included pre-vaccine era CRS incidence, vaccine era CRS incidence, the number of live births per year, and the percentage of CRS cases presenting with an ASD.
Based on our estimates, 16,600 CRS cases (range: 8300-62,250) were prevented by rubella vaccination from 2001 through 2010 in the United States. An estimated 1228 ASD cases were prevented by rubella vaccination in the United States during this time period. Simulating a slight expansion in ASD diagnostic criteria in recent decades, we estimate that a minimum of 830 ASD cases and a maximum of 6225 ASD cases were prevented.
We estimate that rubella vaccination prevented substantial numbers of CRS and ASD cases in the United States from 2001 through 2010. These findings provide additional incentive to maintain high measles-mumps-rubella (MMR) vaccination coverage.
Rubella is a significant public health concern, as maternal rubella infection during pregnancy can lead to congenital rubella syndrome (CRS) in the fetus . CRS comprises various defects, including deafness, cataracts, encephalitis, heart abnormalities, and mental retardation, among others [1, 2]. The severity of CRS depends on the time of infection during gestation, with the most serious complications resulting from maternal infection in the first trimester . The largest rubella epidemic occurred in the United States in the mid-1960s, when more than 20,000 children were born with CRS after an outbreak of over 12.5 million cases of rubella during 1963-1965 [3–5]. Prenatal rubella infection also led to thousands of fetal and infant deaths .
After the epidemic, several large-scale studies were conducted on the so-called "rubella children," establishing a firm link between prenatal rubella infection and congenital disorders [1, 3, 4]. Moreover, Chess found that autism is one of the many outcomes associated with CRS .
Using simple mathematical modeling, we calculated the number of CRS and ASD cases that were prevented by rubella vaccination in the United States from 2001 through 2010. We also performed sensitivity analyses to examine how changes in certain model parameters affect these prevention estimates.
where α and β are vaccine era and pre-vaccine era CRS incidence in the US, respectively, and γ is average number of live births per year. The percentage of CRS cases presenting with an ASD is denoted by δ . This model was chosen as a parsimonious representation of the relationship between a reduction in CRS incidence resulting from rubella vaccination and the incidence of ASD.
Model parameters, estimates, and lower and upper limits
Vaccine era CRS incidence (cases per 10,000 live births)a, b
Pre-vaccine era CRS incidence (cases per 10,000 live births)c
Live births per year (rounded to the nearest 1000)b, d
Percentage of CRS cases presenting with an ASD
Explicit data on pre-vaccine era CRS incidence in the US are limited. The estimate of CRS incidence (β ) and lower and upper limits of this parameter were taken from a study by Stray-Pedersen , which modeled pre-vaccine era CRS incidence in Norway. In general, the values of pre-vaccine era CRS incidence reported by Stray-Pedersen are supported by research from other countries, although individual estimates of CRS incidence vary. Compared to the Norway study, CRS surveillance in Jamaica returned the same overall estimate of CRS incidence (4.0 cases per 10,000 births) . A slightly higher estimate of approximately 5 CRS cases per 10,000 live births was reported from mathematical modeling of pre-vaccine era CRS incidence in Australia . Mathematical modeling by Cutts and Vynnycky  yielded overall estimates of CRS incidence in the range of 17 cases per 10,000 live births in some developing regions. These estimates had very wide ranges , however, and other studies have only reported such high incidence rates during outbreaks . Therefore, taking a conservative approach, we chose to use the value reported from Norway and Jamaica. The Norway and Jamaica studies also obtained the same estimate of endemic CRS incidence (2.0 cases per 10,000 live births) [11, 12]. This value is similar to the estimated 0.81 to 1.27 CRS cases per 10,000 live births derived from a retrospective review of medical records in Morocco  and to the estimated 1 case per 10,000 live births obtained from active surveillance in Yangon, Myanmar . In addition, a review by Cutts, et al. , summarized estimates of epidemic CRS incidence from several countries, ranging from 6 CRS cases per 10,000 live births in Trinidad and Tobago to 22 cases per 10,000 live births in Panama. Within this range fell the Stray-Pedersen estimate of 15 CRS cases per 10,000 live births , and we included this value in our calculations.
The percentage of CRS cases presenting with an ASD (δ ) was obtained from the Chess study of 243 preschool children with CRS . In the Chess study, eighteen children had either the "full" syndrome (meeting all diagnostic criteria) or "partial" syndrome (meeting some but not all diagnostic criteria) of autism, for a total prevalence of 7.4% . Autism diagnosis was based on Kanner's original description of the disorder, published in 1943 . According to Chess, Kanner's classical criteria for autism included "extreme autistic aloneness," language abnormalities, stereotypic relations to the environment, and a lack of affective human contact . In our model, the value of 7.4% was set as the overall estimate of the percentage of CRS cases presenting with an ASD, and lower and upper limits were set at 3.0% and 10.0%, respectively. These limits are designed to be conservative, considering that 1) quantitative data on the CRS-ASD association are limited and 2) current ASD diagnostic criteria are broader and more inclusive than Kanner's classical criteria [18–20].
The estimates in Table 1 were used to calculate the numbers of CRS and ASD cases prevented by rubella vaccination from 2001 through 2010. A one-way sensitivity analysis of the number of CRS cases prevented was performed by varying pre-vaccine era CRS incidence. It is somewhat unreasonable to extend an "endemic" or "epidemic" estimate over a ten-year period because rubella epidemics typically occur every six to ten years in an unvaccinated population . Nevertheless, we decided to employ the endemic estimate to represent the "most conservative scenario," in which CRS incidence remains low in spite of a lack of rubella vaccination. In contrast, extension of the epidemic estimate represents the "least conservative scenario," in which rubella transmission is sustained at high levels in an unvaccinated population. A two-way sensitivity analysis of the number of ASD cases prevented was performed by simultaneously varying pre-vaccine era CRS incidence and the percentage of CRS cases presenting with an ASD.
One-way sensitivity analysis of the number of CRS cases prevented by rubella vaccination, 2001-2010.
Pre-Vaccine Era CRS Incidence
Number of CRS Cases Prevented
Endemic (2.0 cases/10,000 live births)
Overall (4.0 cases/10,000 live births)
Epidemic (15 cases/10,000 live births)
Two-way sensitivity analysis of the number of ASD cases prevented by rubella vaccination, 2001-2010.
Pre-Vaccine Era CRS Incidence
Percentage of CRS Cases Presenting with an ASD
Combining variations in pre-vaccine era CRS incidence and the percentage of CRS cases presenting with an ASD, an estimated minimum of 249 ASD cases and an estimated maximum of 6225 ASD cases were prevented by rubella vaccination from 2001 through 2010 (Table 3). Due to the expansion of ASD diagnostic criteria over time, using the upper limit of the percentage of CRS cases presenting with an ASD may more accurately reflect cases of ASD prevented using current diagnostic criteria. Employing the upper limit of the percentage of CRS cases presenting with an ASD, an estimated 1660 ASD cases (range: 830 to 6225 cases) were prevented by rubella vaccination from 2001 through 2010.
By preventing CRS, rubella vaccination has prevented hundreds, and perhaps thousands, of ASD cases from 2001 through 2010 in the US. These results demonstrate that the CRS-ASD association is not trivial, though the prevented cases represent only a small fraction of current ASD prevalence.
This study relies on estimates from Chess's evaluation of children with CRS. Fombonne, et al., published on the link between autism and other medical disorders in 1997 . The investigators found the rate of CRS among autistic children to be 0.6%, but the association between autism and CRS was not significant. However, given the low overall prevalence of CRS in the population, the relatively small sample size (174 children with autism) would not have been sufficient to detect an association . In addition, the controls selected by Fombonne and colleagues were children with other "medical and developmental problems" and "intellectual deficits," conditions which are also associated with CRS [1, 2, 22]. The findings of Fombonne and colleagues cannot be directly compared to Chess's estimates because Fombonne's study examined the relationship between CRS and autism following implementation of rubella vaccination.
According to Castillo-Solórzano, et al. , "In the United States the lifetime cost of treating a patient with CRS is estimated at more than $200,000." Using the CRS prevention estimates described in Results, rubella vaccination saved the US between $1.7 billion and $12.5 billion by preventing CRS from 2001 to 2010. These cost savings do not include the prevention of stress and emotional suffering for individuals with CRS and their families. Furthermore, since pre-vaccine era CRS incidence was based on the number of live births, these estimates do not account for stillbirths, miscarriages, or induced abortions related to CRS.
Our study is subject to a number of limitations. Because CRS and ASD prevention were estimated through mathematical modeling, the accuracy of prevention estimates is determined by the model parameters. Of the model parameters, estimates of vaccine era CRS incidence and the number of live births per year are based on recent data from reliable sources and, therefore, are expected to be accurate. Although data on these parameters were only available through 2008 and 2009, respectively, substantial changes in these parameters were not expected to occur before the end of the ten-year period (2001 to 2010).
Our results are limited in that we had to rely on the 1971 Chess study  for estimates of the percentage of CRS cases presenting with an ASD; no comparable data were available elsewhere. However, this limitation should lead to underestimation of ASD prevention, since ASD diagnostic criteria have expanded since the Chess study was conducted . With the expansion of Kanner's classical criteria, we expect that more children with CRS would be diagnosed with an ASD today. Additionally, we used data from other countries to estimate pre-vaccine era CRS incidence in the United States because specific data for the US were not available.
Among parents who choose not to have their children vaccinated, vaccine safety concerns are often cited as the reason for vaccine refusal . In a survey of pediatricians and family physicians in the United States in 2000, 69% of physicians perceived a "substantial increase" in parental concerns about vaccine safety . Regarding MMR vaccination, a prospective cohort study of children in the United Kingdom found that 74% of parents of unvaccinated children made a "conscious decision" not to have their children vaccinated with the combined MMR vaccine . Many of these parents claimed to be concerned about vaccine safety, including the potential association between the vaccine and autism. A smaller fraction cited "negative media attention" as a reason for their decision . In the US, where monovalent rubella vaccine is not available, MMR vaccination is the only means of rubella vaccination.
Despite claims that MMR vaccination causes autism, research does not support this association [27–30]. These claims are also ironic in light of our results, which demonstrate that MMR vaccination (through the rubella component of the vaccine) actually prevents cases of autism and other ASDs through the prevention of CRS. Although a disparity between public opinion and scientific fact is evident, physicians and other healthcare providers are in a prime position to address the issue.
Our findings highlight the importance of rubella vaccination in prevention of CRS and resultant autism spectrum disorders. These findings should be incorporated into parental communication materials. Clinicians and public health professionals should continue to educate patients and the public about the benefits of rubella vaccination.
congenital rubella syndrome
autism spectrum disorder
This study was partially funded through the Emory University Global Health Institute which had no role in the design and conduct of the study; management, analysis, and interpretation of the data; and preparation and submission of the final manuscript. No honorarium, grant, or other form of payment was given to anyone to produce this manuscript.
- Cooper L, Krugman S: Clinical manifestations of postnatal and congenital rubella. Arch Ophthalmol. 1967, 77 (4): 434-439.View ArticlePubMedGoogle Scholar
- Miller E, Cradock-Watson J, Pollock T: Consequences of confirmed maternal rubella at successive stages of pregnancy. Lancet. 1982, 2 (8302): 781-784.View ArticlePubMedGoogle Scholar
- Sever J, Nelson K, Gilkeson M: Rubella epidemic, 1964: effect on 6,000 pregnancies. Am J Dis Child. 1965, 110 (4): 395-407.View ArticlePubMedGoogle Scholar
- Lindquist J, Plotkin S, Shaw L, Gilden R, Williams M: Congenital rubella syndrome as a systemic infection. Studies of affected infants born in Philadelphia, U.S.A. Br Med J. 1965, 2 (5475): 1401-1406. 10.1136/bmj.2.5475.1401.View ArticlePubMedPubMed CentralGoogle Scholar
- Rubella. Epidemiology and Prevention of Vaccine-Preventable Diseases. Edited by: Atkinson W, Wolfe S, Hamborsky J, McIntyre L. 2009, Washington, D.C.: Public Health Foundation, 157-176. 11
- Duszak R: Congenital rubella syndrome--major review. Optometry. 2009, 80 (1): 36-43.View ArticlePubMedGoogle Scholar
- Chess S: Autism in children with congenital rubella. J Autism Child Schizophr. 1971, 1 (1): 33-47. 10.1007/BF01537741.View ArticlePubMedGoogle Scholar
- Summary of notifiable diseases--United States, 2008. MMWR Morb Mortal Wkly Rep. 2010, 57 (54): 1-94.
- Births, marriages, divorces, and deaths: provisional data for 2009. Natl Vital Stat Rep. 2010, 58 (25): 1-6.
- Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Mathews TJ, Kirmeyer S, Osterman MJ: Births: final data for 2007. Natl Vital Stat Rep. 2009, 58 (24): 1-85.Google Scholar
- Stray-Pedersen B: Economic evaluation of different vaccination programmes to prevent congenital rubella. NIPH Ann. 1982, 5 (2): 69-83.PubMedGoogle Scholar
- Baxter D: Control of the congenital rubella syndrome in Jamaica. West Indian Med J. 1986, 35 (1): 50-54.PubMedGoogle Scholar
- Menser MA, Hudson JR, Murphy AM, Upfold LJ: Epidemiology of congenital rubella and results of rubella vaccination in Australia. Rev Infect Dis. 1985, 7 (Suppl 1): S37-41.View ArticlePubMedGoogle Scholar
- Cutts F, Vynnycky E: Modelling the incidence of congenital rubella syndrome in developing countries. Int J Epidemiol. 1999, 28 (6): 1176-1184. 10.1093/ije/28.6.1176.View ArticlePubMedGoogle Scholar
- Cutts F, Robertson S, Diaz-Ortega J, Samuel R: Control of rubella and congenital rubella syndrome (CRS) in developing countries, Part 1: Burden of disease from CRS. Bull World Health Organ. 1997, 75 (1): 55-68.PubMedPubMed CentralGoogle Scholar
- Bloom S, Rguig A, Berraho A, Zniber L, Bouazzaoui N, Zaghloul Z, Reef S, Zidouh A, Papania M, Seward J: Congenital rubella syndrome burden in Morocco: a rapid retrospective assessment. Lancet. 2005, 365 (9454): 135-141. 10.1016/S0140-6736(05)17703-4.View ArticlePubMedGoogle Scholar
- Thant K, Oo W, Myint T, Shwe T, Han A, Aye K, Aye K, Moe K, Thein S, Robertson S: Active surveillance for congenital rubella syndrome in Yangon, Myanmar. Bull World Health Organ. 2006, 84 (1): 12-20.View ArticlePubMedPubMed CentralGoogle Scholar
- American Psychiatric Association: American Psychiatric Association. Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV. 1994, Washington, DC: American Psychiatric Association, 4Google Scholar
- Kanner L: Autistic disturbances of affective contact. Nervous Child. 1943, 2: 217-250.Google Scholar
- Blaxill M: What's going on? The question of time trends in autism. Public Health Rep. 2004, 119 (6): 536-551. 10.1016/j.phr.2004.09.003.View ArticlePubMedPubMed CentralGoogle Scholar
- Plotkin S: The history of rubella and rubella vaccination leading to elimination. Clin Infect Dis. 2006, 43 (Suppl 3): S164-168.View ArticlePubMedGoogle Scholar
- Fombonne E, Du Mazaubrun C, Cans C, Grandjean H: Autism and associated medical disorders in a French epidemiological survey. J Am Acad Child Adolesc Psychiatry. 1997, 36 (11): 1561-1569.PubMedGoogle Scholar
- Castillo-Solorzano C, Carrasco P, Tambini G, Reef S, Brana M, de Quadros C: New horizons in the control of rubella and prevention of congenital rubella syndrome in the Americas. J Infect Dis. 2003, 187 (Suppl 1): S146-152.View ArticlePubMedGoogle Scholar
- Omer S, Salmon D, Orenstein W, deHart M, Halsey N: Vaccine refusal, mandatory immunization, and the risks of vaccine-preventable diseases. N Engl J Med. 2009, 360 (19): 1981-1988. 10.1056/NEJMsa0806477.View ArticlePubMedGoogle Scholar
- Freed G, Clark S, Hibbs B, Santoli J: Parental vaccine safety concerns. The experiences of pediatricians and family physicians. Am J Prev Med. 2004, 26 (1): 11-14. 10.1016/j.amepre.2003.09.004.View ArticlePubMedGoogle Scholar
- Pearce A, Law C, Elliman D, Cole T, Bedford H: Factors associated with uptake of measles, mumps, and rubella vaccine (MMR) and use of single antigen vaccines in a contemporary UK cohort: prospective cohort study. BMJ. 2008, 336 (7647): 754-757. 10.1136/bmj.39489.590671.25.View ArticlePubMedPubMed CentralGoogle Scholar
- DeStefano F: Vaccines and autism: evidence does not support a causal association. Clin Pharmacol Ther. 2007, 82 (6): 756-759. 10.1038/sj.clpt.6100407.View ArticlePubMedGoogle Scholar
- Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J: Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ. 2002, 324 (7334): 393-396. 10.1136/bmj.324.7334.393.View ArticlePubMedPubMed CentralGoogle Scholar
- Madsen K, Hviid A, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, Olsen J, Melbye M: A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002, 347 (19): 1477-1482. 10.1056/NEJMoa021134.View ArticlePubMedGoogle Scholar
- Institute of Medicine (U.S.): Board on Health Promotion and Disease Prevention., Institute of Medicine (U.S.). Immunization Safety Review Committee. Immunization safety review: vaccines and autism. 2004, Washington, D.C.: National Academies PressGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/11/340/prepub
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