Psychosocial Syndemic of Suicidal Ideation Among Sexually Transmitted infection Patients in Shanghai, China

Background We sought to verify whether psychosocial health problems among patients with sexually transmitted infections (STIs) were associated with these patients’ suicidal ideation, and to examine the magnifying effect of a syndemic of multiple psychosocial conditions on suicidal ideation. Methods This was a cross-sectional study of 519 STI patients at the Shanghai Skin Disease Hospital. Sociodemographic, psychosocial, and suicidal ideation information on the participants was collected. Logistic regressions were performed to detect the association between sociodemographic variables and suicidal ideation, as well as each individual psychosocial variable and suicidal ideation, and to verify the syndemic effect of psychosocial factors. Results Of the participants, 25.0% reported having suicidal thoughts. In univariate analysis, low self-esteem, loneliness, depression, entrapment, defeat, and unsatisfied interpersonal needs were associated with suicidal ideation. Multivariable analysis found depression (risk ratio RR 2.614; 95% confidence interval CI: 1.603–4.262) and entrapment (RR: 4.457; 95%CI: 2.649–7.496) remained significant. STI patients who experienced two or more psychosocial health problems had approximately five times the odds of suicide ideation (adjusted risk ratio ARR: 4.643; 95%CI: 2.882–7.481) compared with those in the non-syndemic group, especially in the high-level (five or more psychosocial problems) group (ARR: 6.072; 95%CI: 3.307–11.152). Conclusions The study confirmed that STI patients have a high rate of suicidal ideation and suffer from severe psychosocial problems. The results confirm a syndemic effect of psychosocial problems on increasing the odds of suicidal ideation. This suggests greater attention should be paid to STI patients’ psychosocial wellbeing in both nursing and interventions. Efforts to prevent suicidal ideation among STI patients are therefore urgently needed to ameliorate the social and health conditions of this population.

3 Background According to WHO(World Health Organization), one person die every 40 seconds from suicide. However, suicide can be preventable. Suicidal ideation(SI),defined as thinking about, considering or planning for suicide [1] , often may be the prodrome for later suicide.
Those who have SI have higher risk for suicide than those without SI. SI also may indicate one person suffer from great distress and psychological burden. Those who suffer from sexually transmitted infections(STIs) usually endure discrimination and stigma which may due to SI eventually.
Some studies reported 31% to 43.1% in people living with HIV/AIDS (PLWHA) [2][3][4] , which a meta-analysis of China general population reported the estimated lifetime prevalence of SI ranged from 3.1% to 56.0% [5,6] . However, no data for suicidal ideation prevalence in STI patients.
One study in Jamaica surveyed STI patients showed 65.5% participants screened positive for at least one psychiatric disorder including depression, suicidal ideation [7] . Previous studies revealed the association between certain psychosocial conditions and suicidal ideation. Studies have confirmed that low self-esteem and depression are the principal factors behind suicidal ideation [8][9][10][11][12][13][14][15][16][17][18] , and more-current articles have reported that loneliness, unsatisfied interpersonal needs, entrapment, defeat, and poor social support are also strong predictors of suicidal ideation 12,14,[19][20][21] . One study conducted in China reported that poor social support was the strongest predictor of suicidal ideation, in addition to depression and low self-esteem 19 . In two recent studies, one reported loneliness and low social support might represent the most important components of connectedness, as they were found associated with depression severity and suicidality in United States, and another, in Swaziland, reported that feeling lonely was a risk factor for suicidal ideation [22][23] . Defeat and entrapment were key variables of Williams' cry of pain model of suicide, and central to O'Connor's integrated motivational-volitional (IMV) model [24][25] . Additionally, recently, Joiner proposed the interpersonal theory of suicide (IPTS) 26 , which asserted that suicidal ideation emerges when individuals experience thwarted belongingness (TB; loneliness and lack of reciprocal care) and perceived burdensomeness (PB; perceived liability to others and self-hate).
Notably, some researchers have noted that participants with several psychosocial conditions have magnified suicidal ideation 27 . We therefore wish to raise the "syndemic" theory. Syndemic as a term was first proposed by Singer to describe "synergistically related" epidemics that cluster and arise from harmful social conditions 28 . A syndemic effect, or synergistic epidemic is the aggregation of two or more concurrent or sequential epidemics or disease clusters in a population with biological interactions, which exacerbate the prognosis and burden of disease. To our knowledge, most research on the mechanism of suicidal ideation among STI patients (including people with HIV) has typically focused on a single psychosocial factor 6,29-30 . Another matter we realized is that these studies contain behavioral habits, risky sexual behaviors, unpleasant sexual experiences, and psychosocial conditions which involves privacy, are not easy to get true answers and do not apply to the mainstream culture of China. Furthermore, some research has even considered STIs as a factor of the syndemic effect on suicidal ideation, while our present study focused particularly on STI patients' psychosocial issues 28,[31][32] . Only one study has discussed the association between a syndemic effect of psychosocial complements (depression, self-esteem, and social support) and suicidal ideation among HIV+ patients; that was in Nanjing, China 32 . Among other populations is a study our team conducted that found the psychosocial syndemic effect (self-esteem, depression, social support, and loneliness) and suicidal ideation in men who have sex with men (MSM), also in China 29 . The present study used defeat, entrapment, and poor interpersonal need as psychosocial factors in addition to depression, low self-esteem, loneliness, and poor social support, for uncovering whether the syndemic effect would be similar among STI patients, while considering the association with suicidal thoughts.
Our research aim herein is to verify two hypotheses: (1) STI patients suffer several psychosocial conditions that lead to suicidal ideation, and (2) there is a psychosocial syndemic effect in suicidal ideation among STI patients.

Participants
This cross-sectional study, started in November 2017, was conducted for 6 months among STI clinic patients in two branch institutes of the Shanghai Skin Disease Hospital: Qiujiang Road and Baode Road (both in the Jingan District, Shanghai). The hospital specializes in STIs and is one of the premier medical institutes in this field.
Eligibility criteria: According to the newly revised measures for prevention and control of STI diseases of China, STI patients in our article refer to five types of STIs as needing prevention measures: syphilis, gonorrhea, condyloma acuminatum, genital herpes, and the human immunodeficiency virus (HIV).
A questionnaire survey was conducted among STI patients (including inpatient and outpatient) who came to STD Department (Sexually transmitted disease department) on Wednesday and Saturday by accidental sampling. Those who met the following criteria were invited: aged ≥18 years, clinically diagnosed with an STI disease, and able to read the informed consent form.
Exclusion criteria: The following patients were excluded: severe mental or cognitive impairment, unconsciousness, reluctance to cooperate, serious audio-visual impairment or poor reading ability, and/or unable to understand the study's aims and contents.
Sample size: Assuming prevalence of lifetime suicidal ideation in STI patients of 30.0%, using alpha of 0.05 and a relative error for sampling of 0.15, we calculated a required sample size of 415 6,33 . To allow for a 30% non-response rate, a total of 540 patients were recruited to participate in this investigation, and 519 (96.1%) valid questionnaires were collected.

Ethics
The Shanghai Jiao Tong University School of Medicine Public Health and Nursing Ethics Committee approved the present study (approval number: SJUPN-201702). Background information on the survey was given orally to all participants, after which they were given written informed consent forms. These set out the study's goal and procedures, as well as the potential risks. Written informed consent was obtained from all participants before the study began. During the recruitment and interview procedure, participants were free to ask any questions and to withdraw if they did not wish to continue.

Procedure
Our survey team signed cooperation agreements with the Shanghai Skin Disease Hospital before beginning the survey. All the doctors who worked in the STI department (inpatient or outpatient) were recruited and were informed about the survey beforehand. The doctors then informed each participant about the survey before each interview. All the interviewers were recruited from among senior medical students and graduate students at the Shanghai Jiao Tong University School of Medicine. They were trained before the interviews and had several in-person reviews throughout the study. The training also incorporated quality-control strategies, such as reexamining and investigating the questionnaires and resolving issues that may arise during the fieldwork. Interviewers carried out anonymous face-to-face interviews with the participants in a separate room to protect their privacy and to collect valid data. All participants received 80 RMB (approximately US$12) cash for their participation. Each participant received a copy of the survey, and the interviewers offered to read the questions to the participants if necessary.

Sociodemographic Variables
Sociodemographic variables included age, gender, educational level, marital status, residency, income, insurance, sexual orientation, and HIV status.

Suicidal ideation
Suicidal ideation was measured with one question 6 : "Have you ever thought about committing suicide?" (hereinafter defined as suicidal ideation; 0=no, 1=yes).

Self-esteem
Self-esteem was assessed based on the 10-item Rosenberg Self-Esteem Scale (SES).
Negative statements such as "all in all, I am inclined to feel that I am a failure" required a reverse in score (e.g., 0=3, 1=2, 2=1, 3=0) before adding to the total. Low self-esteem was indicated with a result <29 (norm for a Chinese population in China was 28.75) 34 (Cronbach's α: 0.847; range: 12-40).

Loneliness
The initial version of the UCLA Loneliness Scale used 20 questions (e.g., "I lack companionship") designed to estimate participants' loneliness and related emotional states 35 . Hays and DiMatteo identified a highly correlated alternative of eight items (ULS-8), to achieve similar reliability but reduce the respondent's time burden and improve the quality of the data 36 . In this study we used the latter format (Cronbach's α: 0.820; range: . The more loneliness the individual felt, the higher score that person would give, with a cut-off point set at the 75th percentile; a score of 18.

Depression
Depression level was gauged using the Patient Health Questionnaire-9 (PHQ-9), a brief screening tool comprising nine items that match diagnosis criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Individuals were asked to recall how often they had been bothered by worrisome problems (e.g., "little interest or pleasure in doing things") over the last 2 weeks, from not at all (1) to nearly every day (4). A cut-off point of an algorithm score of 5 showed good screening performance within various settings 37 (Cronbach's α: 0.910; range: 0-27).

Entrapment
Evaluation of entrapment was quantified using the 16-question Entrapment Scale (ES) 38 , which reflected the escape motivation triggered either by perception of the outside world(e.g., "I am in a relationship I can't get out of") or internal feelings (e.g., "I want to get away from myself") (Cronbach's α: 0.965; range: 0-64). Any report outcome higher than the 75th percentile-a score of 21-was defined as high entrapment.

Defeat
For the 16-item Defeat Scale (DS) 38 , participants were asked about how they had thought about themselves in the preceding 7 days. Three items (2,4,9) were recoded before computing. Their scores were calculated by summing the items for each scale (scored 0-4) (Cronbach's α: 0.886; range: 0-56). Any report outcome higher than the 75th percentile-a score of 23-was defined as high defeat.

Interpersonal Needs
Interpersonal needs were measured using the 15-item Interpersonal Needs Questionnaire (INQ-15) scale. Respondents rate how often they feel a certain way (e.g., "These days, the people in my life would be better off if I were gone"), ranging from not at all true for me (1) to very true for me (7). Six items (7,8,10,13,14) have to be recoded before computing.
Any report outcome higher than the 75th percentile score of 49 would be defined as unsatisfied with interpersonal needs (Cronbach's α: 0.855; range: 15-96).

Perceived Social Support
The Multidimensional Scale of Perceived Social Support (MSPSS) is a 12-item, seven-point Likert scale based on the self-reported measure of support received from family, friends, and other people of special significance(e.g., "there is a special person with whom I can share joys and sorrows"). Ranging from very strongly disagree (1) to very strongly agree (7), higher mark indicated better social support, and the 25th percentile-score of 59-was adopted as the cut-off point (Cronbach's α: 0.947; range: 12-84).

Syndemic of psychosocial variables
If two or more psychosocial conditions were concurrent in a participant, we assumed there was a syndemic phenomenon 39

Psychosocial Health Conditions Among STI Patients
A total of 519 patients (average age: 36.75±11.523 years) were investigated. Using the 75th percentile as the cut-off point, one-quarter of the participants were classified as lonely, at a high level of entrapment and defeat, and lacking in interpersonal needs. When using the 25th percentile as the cut-off, three-quarters of the respondents were found to be lacking social support. About half (48.36%) showed depression via the PHQ-9. A total of 38.92% were found to have a low level of self-esteem (Table 1).  Homosexual respondents were more likely to report suicidal ideation than heterosexual respondents (OR: 3.352; 95%CI: 1.587-7.084).    showed a prominent additive effect in thinking about suicide compared with those in the non-syndemic group. Consistent with previous studies, our study found suicidal ideation was independently associated with low self-esteem, depression, loneliness, entrapment, defeat, and interpersonal need. According to cognitive theory, low self-esteem is processed in a typically negative manner, which leads to negative self-appraisal and later to suicidal ideation 49 . As suicidal ideation is among the diagnostic criteria for depression, its presence in and of itself will necessarily increase the number of depressive symptoms.

Verification of Syndemic Effect of Psychosocial Variables
Feeling lonely was associated with distress, which is strongly associated with generalized anxiety; panic attacks with suicidal ideation 50 . The association between loneliness and suicidality supports the theory that thwarted belongingness and perceived burdensomeness are major determinants of suicidality 26 . The relationship between defeat, entrapment, and suicidal ideation is the motivational phase of the IMV model 25 , and also established key variables within Williams' cry of pain theory of suicide 24 . Previous research is equivocal regarding the relationship between social support and suicidal ideation.
When we included all psychosocial conditions in a single model, the association with suicidal ideation was removed for most psychosocial variables, though remained strongest for depression and entrapment. This should not be surprising, considering suicidal ideation and behavior are known as outcomes of feeling trapped in a stressful situation, with no evident escape or rescue possible 51 ; this has been found in diverse populations and in the context of various disorders and research methodologies [45][46] . Despite prevalence of poor psychosocial status among STI patients, huge gaps are still visible in concern and service, due to inadequate information and emotional support, and a shortage of qualified psychosocial professional treatment 8,52-54 .
To show that suicidal ideation also co-occurs among STI patients, we have extended previous research that confirmed there was a syndemic effect on suicidal ideation in MSM 27 . We confirmed all seven psychosocial health problems tend to co-occur and act to raise risk levels for suicidal ideation in these patients. However, the measurement of the syndemic construct is not invariant across groups; therefore, the construct's meaning also differs. A previous study showed syndemics are in fact a general human phenomenon, but their composition differs and the consequences are felt most deeply by those in the minority, such as MSM and men who have sex with men and women 55 . These results support the notion that syndemic theory has the potential to advance research, theory, and interventions related to suicidal ideation in this population.

Consent for publication
Not applicable

Availability of data and material
All data generated or analyzed during this study are included in this published article [and its supplementary information files].

Competing interests
All financial and non-financial competing interests must be declared in this section.

Funding
National Natural Science Foundation of China, 71673187--Research on intervention strategies for HIV high-risk behaviors of transgender men with male behaviors based on IMB model

Authors' contributions
Yong Cai substantially contributed to the conceptualization and design of this research, and to revising the manuscript. Jin Ma contributed to conceptualizing this manuscript and also wrote sections of the manuscript. Suping Wang assisted the study design, data collection, and registration of the data from hospital files, data analyses, data interpretation, and drafting the manuscript. Ruijie Gong contributed to data analyses, data interpretation, and to drafting and revising the manuscript. Yang Ni substantially contributed to the data collection and cooperation with the hospital.
Pingyu Zhou and Yang Ni at the Shanghai Skin Disease Hospital. We thank Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac) for editing a draft of this manuscript.