Systematic review of burnout among healthcare providers in sub-Saharan Africa

Background Burnout is characterized by physical and emotional exhaustion from long-term exposure to emotionally demanding work. Burnout affects interpersonal skills, job performance, career satisfaction, and psychological health. However, little is known about the burden of burnout among healthcare providers in sub-Saharan Africa. Methods Relevant articles were identified through a systematic review of PubMed, Web of Science (Thomson Reuters), and PsycINFO (EBSCO). Studies were selected for inclusion if they examined a quantitative measure of burnout among healthcare providers in sub-Saharan Africa. Results A total of 65 articles met our inclusion criteria for this systematic review. Previous studies have examined burnout in sub-Saharan Africa among physicians (N = 12 articles), nurses (N = 26), combined populations of healthcare providers (N = 18), midwives (N = 2), and medical or nursing students (N = 7). The majority of studies assessed burnout using the Maslach Burnout Inventory. The highest levels of burnout were reported among nurses, although all healthcare providers showed high burnout. Burnout among healthcare providers is associated with their work environments, interpersonal and professional conflicts, emotional distress, and low social support. Conclusions Available studies on this topic are limited by several methodological challenges. More rigorously designed epidemiologic studies of burnout among healthcare providers are warranted. Health infrastructure improvements will eventually be essential, though difficult to achieve, in under-resourced settings. Programs aimed at raising awareness and coping with burnout symptoms through stress management and resilience enhancement trainings are also needed. Electronic supplementary material The online version of this article (10.1186/s12889-019-7566-7) contains supplementary material, which is available to authorized users.


Introduction
Burnout is a psychological syndrome involving emotional exhaustion, feelings of helplessness, depersonalization, negative attitudes towards work and life, and reduced personal accomplishment [1]. The prevalence of burnout in high-income countries among the general working population has been reported to range between 13 and 27% [2,3]. However, healthcare providers have been described as a high-risk population for experiencing burnout [4][5][6], and the prevalence of burnout among healthcare providers has been increasing in recent years [7]. The prevalence among physicians is reported to be as high as 70% [8] and nearly 50% among nurses [6,9,10]. Studies conducted in the United States show 54% of physicians [7], 35% of hospital nurses [11], and 35.2% of medical students reported burnout [12]. Similar rates of burnout among healthcare providers have been reported in other high-income countries [13][14][15].
Burnout is of great public health concern due to its physical health consequences including aches, digestive upset, and poor quality of life [12,[16][17][18]. Furthermore, burnout is highly comorbid with a myriad of psychiatric disorders including depression [19,20], anxiety [21], substance abuse [19,22], and suicidality [12,23] among healthcare providers. In addition to self-reported health outcomes, burnout is associated with hypothalamus-pituitary-adrenal axis dysregulation [24][25][26], inflammatory responses [27,28], and increased allostatic load [29,30]. It has been reported that individuals with occupational burnout exhibit changes in the brain, such as reduction in gray matter volume of the anterior cingulate, caudate and putamen [31]. In addition, occupational burnout has also been associated with a reduced ability to downregulate emotional stressors, altered functioning of the limbic networks [32], and changes in subcortical volume [33]. Studies have shown that physicians with burnout are more likely to report career dissatisfaction and intention to leave the medical profession [34]. Lastly, burnout among healthcare providers has been associated with increased self-reported errors, reduction in time devoted to providing clinical care, and higher mortality rates [35,36]. In summary, burnout among healthcare providers has profound personal and professional consequences, impacting the quality of patient care and functionality of healthcare systems [37].
Furthermore, appallingly little is known about the collective burden of burnout and its effects on healthcare providers in low-and middle-income countries [38]. Few studies in low-and middle-income countries have reported burnout among healthcare providers including in China [39,40], Brazil [41], and Egypt [42,43]. Additionally, there has been an exodus of physicians from sub-Saharan Africa due to the global labor market [44,45]. In 2015, about 6% of all international medical graduates in the US workforce were from sub-Saharan Africa [46]. Moreover, in half of the countries in sub-Saharan Africa, more than 30% of physicians trained locally have migrated to high-income countries [47]. This has resulted in shortages of healthcare providers in sub-Saharan Africa, and a higher risk of burnout among those who remain to care for a disproportionally greater number of acutely ill patients [47]. Similar migrations from other low-and middle-income countries [48,49] and from rural areas of high-income countries [50], have led to a scarcity of healthcare providers to care for patients. The remaining healthcare providers have increased responsibility to care for patients and a high risk of burnout. In view of these circumstances, we conducted a systematic literature review to examine the burden of burnout among healthcare providers in sub-Saharan Africa. We were specifically interested in how the construct of burnout was assessed, which healthcare sectors were included, and any interventions that were evaluated. This review is also intended to set the stage for subsequent contributions aimed at reducing the burden of burnout among healthcare providers in sub-Saharan Africa. Effective interventions will need to identify and address individual and structural barriers contributing to burnout among healthcare providers.

Methods
This systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines [51] (Additional file 1: Table  S1).

Study selection and criteria for inclusion
In PubMed, Web of Science (Thomson Reuters), and PsycINFO (EBSCO), we identified studies using search terms for burnout and sub-Saharan African countries (Additional file 1: Table S2). Search terms included all sub-Saharan African countries. All articles published prior to February 14, 2019 were eligible for inclusion. We only included articles available in English. Based on the title and abstract review of all articles, we rejected any articles that were not relevant or did not meet the study criteria. Studies were selected for inclusion if (1) they examined a quantitative measure of burnout, (2) the study population was healthcare providers, and (3) the study was conducted in a sub-Saharan African country. Healthcare providers included physicians, nurses, medical or nursing students, midwives, and other hospital workers. Studies were excluded for (1) not including a quantitative measure of burnout, (2) not measured in healthcare providers, or (3) not conducted in sub-Saharan Africa.
Full texts of articles examining populations of healthcare providers were reviewed. Reference sections of included articles were also reviewed for additional relevant studies. A companion article examines burnout among healthcare providers in the Middle East and Northern Africa (Chemali et al, under review).

Data extraction and quality assessment
The following data were extracted independently for each included article: first author, publication year, study population, burnout assessment, reported burnout, and main findings. P-values, confidence intervals, and odds ratios were extracted when available. Methodological quality of studies was assessed using the Newcastle-Ottawa Scale for cross-sectional studies [52], the Newcastle-Ottawa Scale for cohort studies [53], and the Cochrane Risk of Bias Tool for randomized controlled trials [54]. Study quality assessment is presented in Additional file 1: Tables S3, S4, S5, and S6.

Findings
The initial literature search identified a total of 233 unique articles in PubMed, 384 articles in PsycINFO, and 322 articles in the Web of Science database (Fig. 1). Duplicate articles were removed, and 740 unique articles remained for title review. Articles were rejected on title review if they were not relevant or did not meet search criteria. After reviewing article titles, 363 articles remained for abstract review. Candidate abstracts of the remaining studies were rejected for not being relevant or not meeting the search criteria. Studies in populations of healthcare providers (N = 144) were selected for full-text review. In the full-text review, articles were rejected if they were qualitative studies, not available in English, did not include healthcare providers, or were not relevant to the search criteria.
A total of 65 articles met our inclusion criteria for this systematic review. Included articles examined burnout in sub-Saharan Africa among physicians (N = 12 articles), nurses (N = 26), combined populations of healthcare workers (N = 18), midwives (N = 2), and medical or nursing students (N = 7). Twenty-seven studies examined burnout among healthcare providers in South Africa, 13 studies in Nigeria, 4 studies in Ethiopia, and 4 studies in Ghana. Three studies each examined burnout among healthcare providers in Cameroon and Malawi. Two studies each examined burnout among healthcare providers in Kenya and Zambia. One study each examined burnout in Zimbabwe, Botswana, Mozambique, Uganda, Namibia, and Senegal. Additionally, one study examined burnout in Kenya, Tanzania, and Uganda. Of the 65 eligible articles for inclusion, 45 used versions of the Maslach Burnout Inventory (MBI) to measure burnout. An additional 5 studies used the burnout subscale of the Professional Quality of Life Scale (ProQOL), 4 studies used the Oldenburg Burnout Inventory, 3 studies used the Copenhagen Burnout Inventory, 1 study used the Executive Burnout Scale, and 1 study used the Compassion Fatigue Self Test.

Burnout among physicians
Twelve articles examined burnout among physicians in sub-Saharan Africa, comprising a total of 2031 participants across Ethiopia, Nigeria, Ghana, and South Africa (Table 1). In nine of the studies, burnout was assessed using the Maslach Burnout Inventory-Human Services Survey (MBI-HSS) [56,57,61,66], MBI [55,58,60,64], or an abbreviated MBI [59]. One study assessed burnout using the Copenhagen Burnout Inventory [63]. In South Africa, Schweitzer used one question ('Do you ever feel so emotionally exhausted that you feel negative about yourself and about your job and lose the feeling of concern for your patients?') to assess burnout based on the definition in Pine and Maslach [67]. Lastly in Nigeria, two questions were used to examine emotional exhaustion ('I feel burned out from my work') and depersonalization ('I have become more callous toward people since I took this job') [65].
Physicians reported high levels of burnout. For example, among physicians at rural district hospitals in South Africa (N = 36), 81% of participants reported burnout, with 31% reporting high burnout on all three of the MBI-HSS subscales [56]. On the MBI-HSS subscales, 65.2% of physicians in southern Ethiopia (N = 491) reported high emotional exhaustion, 91% low personal accomplishment, and 85.1% high depersonalization [57]. Physicians undergoing residency training at a hospital in Nigeria (N = 204) reported a high prevalence of burnout according to the MBI, in which 45.6% of residents reporting burnout on emotional exhaustion, 57.8% depersonalization, and 61.8% reduced personal accomplishment [58]. Among physicians who participated in the web-based survey in Ghana (N = 200), burnout measures were high on the emotional exhaustion (mean ± standard deviation (SD): 9.1 ± 2.6), personal accomplishment (5.8 ± 1.6), and depersonalization (5.2 ± 2.1) subscales of the abbreviated MBI [59]. South African physicians in public sector emergency centers (N = 93) had high burnout scores on all subscales of the MBI-HSS [61]. Among physician anesthetists at a university hospital in South Africa, 45 . In a population of junior physicians in South Africa (N = 126), 77.8% had experienced burnout, with 52.4% experiencing burnout at their current job. Among these doctors, scores on the Physician Stress Inventory were significantly higher among those with burnout (p < 0.001) [62]. Lastly, in a small mixed-methods study of junior physicians at a children's hospital in South Africa (N = 22), all participants experienced high levels of burnout on at least 1 MBI subscale, and mean scores on the emotional exhaustion and depersonalization subscales were significantly higher than those in a normative comparison group (p < 0.001) [64].

Burnout among nurses
A total of 26 articles examined burnout among nurses in Ghana, South Africa, Nigeria, Kenya, Tanzania, Uganda, Cameroon, Namibia, and Zimbabwe ( Table 2). The majority of studies were conducted in South African (N = 13) or Nigerian (N = 8) nursing populations. Of the 26 articles, a total of 20 studies used the Maslach Burnout Inventory-General Survey (MBI-GS), MBI-HSS, MBI, or the MBI emotional exhaustion subscale to measure burnout. Two studies used the Oldenburg Burnout Inventory [74,85], one study used the burnout subscale of the ProQOL [83], and one study used first-hand coding by an observer according to the Exhaustion-Disengagement Model [84], which uses job demand and resources to identify exhaustion and disengagement. One study used the Executive Burnout Scale, which was developed in Nigeria as a culturally-sensitive tool to measure burnout [68,95]. One study did not specify the burnout measure used [73]. A total of 5 studies did not report measured burnout levels in the study population [79,84,86,89,94].
High levels of reported burnout were found in nursing populations ( Table 2). For example, in a large study of nurses at national referral hospitals in South Africa (N = 1187), 45.8% participants reported high levels of burnout on the emotional exhaustion subscale of the MBI [71]. Among hospital nurses in Nigeria (N = 270), 39.1% had burnout on the emotional exhaustion subscale of the MBI, 29.2% on the depersonalization subscale, and 40.0% on the reduced personal accomplishment subscale [81]. In a population of nurses at private and public hospitals in Kenya, Tanzania, and Uganda, (N = 309), 32.1% reported burnout on the MBI [91]. Among nursing populations in South Africa, burnout was associated with high workloads [73,76,82,89] and lack of support [79,80,91,92].

Burnout among combined populations of healthcare workers
A total of 18 articles examined burnout among combined populations of healthcare workers (Table 3). Three studies each were conducted in Ethiopia and Malawi.  One question worded: "Do you ever feel so emotionally exhausted that you feel negative about yourself and about your job and lose the feeling of concern for your patients?" 77.8% had experienced burnout, 52.4% were experiencing burnout at current job, and 61% experienced burnout at a previous job.
Physician Stress Inventory (PSI) score was significantly higher among participants with burnout (p < 0.001). Doctors who were able to communicate with the majority of patients had lower burnout than those who could not (p = 0.04) and a lower mean PSI score (p = 0.04).     [99]. Among healthcare workers providing clinical care for HIV-positive patients in Malawi (N = 520), 62% met the MBI criteria for burnout [101]. Additionally, one study used the

MBI-GS Maslach Burnout Inventory -General Survey
Compassion Fatigue Self Test [102] and one used the Copenhagen Burnout Inventory [97]. Two studies measured burnout as a sub-domain of motivation [98,113]. One study measured burnout using a five item scale of occupational burnout [103]. Mutale and colleagues used two questions to measure burnout ("I feel emotionally drained at the end of the day" and "Sometimes when I get up in the morning, I dread having to face another day at work") [107]. In combined populations of healthcare workers, nurses often had the highest level of reported burnout [97,111].

Burnout among midwives
Two studies examined burnout among midwives in Uganda [114] and Senegal [115] (Table 4). Among midwives in two rural districts in Uganda (N = 224), burnout was measured using the burnout subscale of the Professional Quality of Life Scale [114]. Burnout and secondary traumatic stress were associated with level of education (p < 0.01), marital status (p < 0.01), involvement in nonmidwifery health care activities (p < 0.01), and physical well-being (p < 0.01) [114]. Among midwives from 22 hospitals in Senegal (N = 226), 55% reported burnout on the MBI, with 80% reporting burnout on emotional exhaustion, 57.8% on depersonalization, and 12.4% on diminished personal accomplishment subscales. Furthermore, emotional exhaustion was inversely associated with remuneration (p = 0.02) and task satisfaction (p = 0.03). Active job searching was associated with being dissatisfied with job security (p < 0.01), and voluntary quitting was associated with dissatisfaction with continuing education (p < 0.01) [115].

Burnout among health professional students
Lastly, 7 articles examined burnout among medical and nursing students in South Africa or Cameroon (Table 4). Among medical students in South Africa (N = 91), 46.1% reported high, 33.8% moderate, and 20% low burnout on the MBI-HSS burnout scale [116]. Colby and co-authors also found significant associations between scores on the World Health Organization Quality of Life Assessment and the MBI subscales (p < 0.01) [116]. Among oral hygiene students in South Africa, there were significant differences in burnout levels on the MBI subscales between 1st, 2nd, and 3rd year students (p = 0.039) [117]. Among nursing students in South Africa (N = 80), 63.8% had a moderate to high risk of burnout [118]. In a population of undergraduate nursing students in South Africa (N = 67), Mathias and coauthors found on the burnout subscale of the Professional Quality of Life Scale (Pro-QOL) that 6% of participants had low levels of burnout, 94% had moderate, and none reported high levels of burnout [119]. Among nursing students (N = 447) and medical students (N = 413) in Cameroon, burnout was examined using the Oldenburg Burnout Inventory [120,121]. Lastly, in a population of paramedic students in South Africa (N = 93), 31% of participants reported high levels of burnout on the Copenhagen Burnout Inventory [122].
Risk and protective factors associated with burnout among healthcare providers Overall, burnout was associated with measures of the work environment, including heavy workload, inadequate personnel, difficult work conditions, and low career satisfaction. For example, nurses in South Africa with more favorable work environments were less likely to report high levels of burnout (OR = 0.55; 95% CI: 0.41-0.75) [71]. Heavy workloads were also significantly associated with high levels of reported burnout in populations of nurses [76,82,89,91,123] and other healthcare workers [108,109]. Among nurses in South Africa, workload was a significant predictor of emotional exhaustion as measured by the MBI (β = 0.547,p = < 0.001) [76]. Among hospital workers in Nigeria, inadequate number of nursing personnel (OR = 2.6, 95% CI: 1.5-5.1), and frequent night duties (OR = 3.1, 95% CI: 1.7-5.6) were predictors of burnout on the emotional exhaustion subscale of the MBI. Frequent night duties (OR = 2.4, 95% CI: 1.5-4.8) were predictors of burnout on the depersonalization subscale. High nursing hierarchy (OR = 2.7, 95% CI: 1.5-4.8), poor wages (OR = 2.9, 95% CI: 1.6-5.6), and frequent night duties (OR = 2.3, 95% CI: 2.3-4.5) were predictors of burnout on the reduced personal accomplishment subscale of the MBI [81]. Patient care was also affected by high rates of burnout among healthcare providers [79,80,101]. For example, among healthcare providers in Malawi, burnout was associated with self-reported suboptimal patient care (OR = 3.22, 95% CI: 2.11-4.90; p < 0.0001). Additional factors in the work environment associated with burnout include nursing hierarchy and poor wages [81], staffing issues [79], difficulty communicating with patients [62], organizational complaints [89], job insecurity [97], and intention to quit [88].
Among healthcare providers, burnout is also associated with interpersonal and professional conflicts. Burnout is associated with high level of doctor/doctor conflict [58], doctor/nurse conflict [81], work/family conflict [69], and interpersonal conflict in general [89]. Among doctors in Nigeria (N = 204), those who did not report doctor/ doctor conflict were less likely to have burnout on the depersonalization subscale of the MBI (OR = 0.36; 95% CI = 0.17-0.76) [58]. Among nurses in Nigeria (N = 270), doctor/nurse conflict was a predictor of burnout on the MBI emotional exhaustion subscale (OR = 3.1, 95% CI: 1.9-6.3) and on the depersonalization subscale (OR = 3.4, 95% CI: 2.2-7.6) [81]. Among nurses from public hospitals in Ghana (N = 134), work-to-family and family-to-work conflict accounted for 20% of the variance in burnout [69].
Experiences of stress and emotional distress were associated with increased odds of burnout. Among junior physicians in South Africa (N = 126), the Physician Stress Inventory (PSI) score was significantly higher among participants with burnout (p < 0.001) [62]. Physicians undergoing residency training in Nigeria who reported emotional distress were more likely to report burnout (p < 0.001) [58]. In a population of nurses in South Africa (N = 122), emotional management and emotional control, as measured by the Swinburne University Emotional Intelligence test, were associated with self-reported stress and burnout subscales (p < 0.01). Emotional intelligence was a moderator of the relationship between stress and burnout, explaining 59.5% of the  [76]. Among nurses at a hospital in Nigeria, use of emotion-focused coping strategies was positively associated with the MBI burnout subscales of emotional exhaustion (β = 0.32, p = 0.01) and depersonalization (β = 0.18, p = 0.01) [86]. Lastly, social support was found to be protective against burnout among healthcare providers [58,79,80,91,97]. Specifically, among physicians in Nigeria, adequate support from management (OR = 0.45; 95% CI: 0.22-0.90) were protective from burnout on the MBI subscale of reduced personal accomplishment [59]. Among nurses in Kenya, Tanzania, and Uganda (N = 309), lower social support from colleagues was associated with increased burnout on the MBI subscale of higher emotional exhaustion (β = − 0.15, p < 0.05) [91].

Burnout intervention programs
Programs aimed at coping with burnout are sparse. Only two studies, in combined populations of healthcare workers, examined burnout-related interventions [104,105]. The Support, Train and Empower Managers (STEM) study was designed to implement a support intervention and measure the impact on healthcare workers in Mozambique [105]. At baseline, 67.1% of healthcare workers reported low, 15.9% moderate, and 17.1% high burnout on the MBI. After the intervention, 71.1% reported low, 17.8% moderate, and 11.1% high burnout. However, the authors found no statistically significant differences in emotional exhaustion from baseline to post-intervention for any intervention groups. Job satisfaction, emotional exhaustion and work engagement also showed no significant differences between baseline and postintervention [105]. Ledikwe and colleagues examined healthcare workers at a public health facility in Botswana (N = 1348) after participation in Botswana's Workplace Wellness Program (WWP) [104]. Job satisfaction, assessed by the Job In General Scale, was significantly higher for healthcare workers who participated in 7 or more activities in the WWP compared to those who did not participate in any activities (p = 0.004). Healthcare workers who participated in seven or more WWP activities had significantly higher scores on the Job Descriptive Index subscales related to satisfaction with work, supervision, promotion opportunities and pay, with the highest levels found among those participating in seven or more WWP activities (p < 0.05). Additionally, stress levels (p = 0.006), measured on the Stress in General scale, and exhaustion (p < 0.001), measured on the MBI, were significantly lower among those with high participation in WWP activities [104].
In sub-Saharan Africa, the highest levels of burnout were recorded among nurses, although all healthcare providers reported high levels of burnout. High levels of burnout were associated with unfavorable work conditions, high job demands, and low job satisfaction. Studies in sub-Saharan Africa support other studies among healthcare providers that have shown burnout is more common among women [43,127,128], those of younger age [129], and those with less support or resources to manage workloads [39,82,[130][131][132].
Concerns have been raised about how the MBI operationalizes burnout [133]. Despite evidence documenting increasing burnout in sub-Saharan Africa, none of the studies reviewed discuss the conceptual definitions of burnout from a theoretical perspective. Most used the MBI and adopted the three domains of burnout from the MBI scale. Additionally, prior studies have not validated the MBI in healthcare workers in sub-Saharan Africa, and there may be different cultural interpretations of questions related to the construct of burnout. Although it's difficult to quantitatively compare across populations due to variation in how burnout was defined, burnout prevalence reported using MBI subscales ranged from 12.5-65.2% on emotional exhaustion, 5-57.8% on depersonalization, and 25-85.1% on reduced personal accomplishment. On other instruments, burnout prevalence was 52.4% using one question ('Do you ever feel so emotionally exhausted that you feel negative about yourself and about your job and lose the feeling of concern for your patients') [62], 95.4% on the Compassion Fatigue Self-Test [102], 51% using an occupational burnout scale [103], and 63.75% using the ProQOL burnout subscale [118]. Given the variability that exists in assessing burnout in different contexts and with different instruments, there is a need to design studies aimed at evaluating the reliability of various burnout screening instruments crossculturally.
There are additional limitations to the current studies. A total of 18 studies examined burnout among combined populations of healthcare workers in sub-Saharan Africa (Table 3). These populations include all workers in a clinic or hospital setting, who may have highly variable job responsibilities and workload. In addition, the majority of studies were cross-sectional. Only two studies examined burnout-related interventions in sub-Saharan African populations. Additionally, among the included studies, sample sizes were relatively small and study quality varied widely (Additional file 1: Table S3-S6).
Future studies need to address the drivers of burnout among healthcare providers in sub-Saharan Africa. Although burnout among healthcare providers has been associated with violence against healthcare providers [134,135]; few studies have examined violence [99] and secondary traumatic stress [114] in sub-Saharan Africa. Performing longitudinal assessments of burnout along with measurements of mood, substance use, suicidality, cognition, performance and quality of life will add to our understanding of the burnout syndrome and its consequences. Efforts should also include utilizing consistent measures of burnout with an instrument validated in specific geographical and cultural contexts.

Conclusions
Burnout has received a great deal of attention in high-income countries with awareness and intervention programs designed to cope with burnout symptoms. In the United States, a recent report recommends addressing physician burnout by improving physician access to mental health services, improving the usability of electronic medical records, and appointing wellness officials to assess and improve burnout interventions at their institutions [136]. However, burnout among healthcare providers is not only a crisis in high-income countries [124]. It is a significant problem in low and middle income countries as well. Programs aimed at raising awareness, promoting well-being and prevention, and improving coping with burnout symptoms through evidence-based stress management and resilience training in sub-Saharan Africa are needed. Given the ever-increasing burden of major public health threats of communicable and non-communicable diseases in sub-Saharan Africa amidst a dearth of resources and lack of support, along with the adverse health effects of this burden for patients and providers alike, more attention needs to be paid to healthcare provider burnout in low-income settings in Africa and around the world. Additional studies need to address both personal and organizational barriers that increase the risk of burnout among healthcare providers [137]. Individual and structural interventions will need to be combined to effectively reduce burnout among healthcare providers [138]. These interventions should include advocacy for better resource provisions and support for healthcare providers so that healthcare infrastructure and patient care can be improved.

Additional file
Additional file 1: Table S1. Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Table S2. Database terms of search. Table S3. Quality assessment of studies on burnout among physicians in sub-Saharan Africa (N = 12). Table S4. Quality assessment of studies on burnout among nurses in sub-Saharan Africa (N = 26). Table  S5. Quality assessment on burnout among healthcare workers in sub-Saharan Africa (N = 18). Table S6. Quality assessment on burnout among midwives and health professional students in sub-Saharan Africa (N = 9). (DOCX 34 kb)