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Table 3 Multivariate hazard ratios of the incidence of complications according to the age group

From: Chronic disease management program applied to type 2 diabetes patients and prevention of diabetic complications: a retrospective cohort study using nationwide data

Outcomes

Total (n = 9,234)

20–39 years old (n = 1,239)

40–59 years old (n = 5,452)

 ≥ 60 years old (n = 2,543)

n (%) of Events

HRa

95% CI

P value

n (%) of Events

HRa

95% CI

P value

n (%) of Events

HRa

95% CI

P value

n (%) of Events

HRa

95% CI

P value

Overall complications

 CDMP

  No

710 (15.38)

Ref

 

 < 0.0001

60 (9.55)

Ref

 

 < 0.0001

407 (14.88)

Ref

 

 < 0.0001

243 (19.39)

Ref

 

 < 0.0001

  Yes

70 (1.52)

0.079

0.061–0.102

 

5 (0.82)

0.053

0.021–0.133

 

37 (1.36)

0.075

0.054–0.106

 

28 (2.17)

0.090

0.059–0.138

 

Microvascular complications

 CDMP

  No

385 (8.34)

Ref

 

 < 0.0001

43 (6.85)

Ref

 

 < 0.0001

251 (9.17)

Ref

 

 < 0.0001

91 (7.26)

Ref

 

 < 0.0001

  Yes

45 (0.97)

0.092

0.067–0.127

 

4 (0.65)

0.058

0.020–0.164

 

24 (0.88)

0.079

0.051–0.121

 

17 (1.32)

0.136

0.079–0.235

 

Macrovascular complications

 CDMP

  No

376 (8.14)

Ref

 

 < 0.0001

23 (3.66)

Ref

 

0.0011

187 (6.83)

Ref

 

 < 0.0001

166 (13.25)

Ref

 

 < 0.0001

  Yes

28 (0.61)

0.067

0.045–0.100

 

1 (0.16)

0.034

0.004–0.256

 

15 (0.55)

0.076

0.045–0.129

 

12 (0.93)

0.061

0.032–0.116

 
  1. Abbreviations: CDMP Chronic Disease Management Program, HR hazard ratio, CI confidence interval
  2. aAdjusted for age group (all-subject analyses only), sex, year of diagnosis, economic status, healthcare insurance type, region of residence, hypertension, hyperlipidemia, Charlson Comorbidity Index, follow-up period, and pattern of antidiabetic medication prescription