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Table 2 Intervention and outcome characteristics

From: The effect of physical activity on health outcomes in people with moderate-to-severe traumatic brain injury: a rapid systematic review with meta-analysis

Reference

PA Classification

PA Type

Supervised (by whom)

Intensity

Dose Parameters

Group Training (Size)

Location

Progression

Inpatient Rehabilitation

Bateman et al. 2001 [34]

Structured Aerobic Exercise

Cycle Ergometer

Yes (Physiotherapist)

60–80% age predicted HRmax

30-min, 3*/week, 12 weeks

No

Four regional neurologic inpatient rehabilitation units

Exercise time was increased as individually tolerated until the patients were able to cycle for 30-min. Work rate (watts) was then adjusted to raise each individual’s HR into a training zone: 60–80% of age-predicted HRmax

Brown et al. 2005 [39]

Structured Gait/ Balance/ Functional Exercise

Body-Weight Supported Treadmill Training

Yes (Physiotherapist)

30% BWS 0.2–2.3 miles/hr speed

15-min, 2*/week, 14 weeks

No

NR

Reduction in BWS by 10% until 10% BWS was achieved, then reduction by 5%. All reductions were based on achieving 10 consecutive heel strikes bilaterally. Treadmill speed was increased as tolerated.

Canning et al. 2003 [40]

Structured Gait/ Balance/ Functional Exercise

Repetitive Sit-to-Stands and step-up exercises

Yes (Physiotherapist)

NR

5*/week, 4 weeks (duration NR)

No

Brain Injury Rehabilitation Unit

Increased complexity by multitasking i.e., holding cup of water. Increased speed, lowering of chair from 110–90% of lower leg length by week four. Aim was to complete 100 sit-to-stand repetitions and 60 step-ups daily, 5*days/week.

Curcio et al. 2020 [41]

Structured Gait/ Balance/ Functional Exercise

Aquatic therapy targeting enhanced postural stability and gait exercises

Yes (Physiotherapist)

NR

45-min, 3*/week, 4 weeks

NR

Hydro pool, Neurorehabilitation hospital

NR

Cuthbert et al. 2014 [42]

Structured Gait/ Balance/ Functional Exercise

VR-based balance therapy (Nintendo Wii)

Yes (Physiotherapist)

NR

15-min, 4*/week, 4 weeks

No

Hospital Gym

NR

Freivogel et al. 2009 [47]

Structured Gait/ Balance/ Functional Exercise

Robotic Body-Weight Supported Treadmill Training (LokoHelp)

Yes (Physiotherapist)

Maximal treadmill speed tolerable by participant

30-min, 3–5*/week, 6 weeks

No

Inpatient Hospital gym

Initial BWS ranged from 10-30% and was reduced as soon as possible

Wilson et al. 2006 [58]

Structured Gait/ Balance/ Functional Exercise

Partial Body-Weight Supported gait training

Yes (Physiotherapists and assistants)

NR

Max 60-min, 2*/week, 8 weeks

No

Hospital gym

% BWS reduced when participant showed no sign of discomfort with walking pace. Treadmill speed also increased when no assistance was needed, and participant showed no signs of discomfort or discoordination due to walking pace.

Outpatient Rehabilitation

Esquenazi et al. 2013 [46]

Structured Gait/ Balance/ Functional Exercise

Robotic Body Weight Supported Treadmill Training

Yes (Physiotherapist)

Based on Self-Selected Velocity and/or Maximum Velocity at 10–20% BWS

60-75-min, 3*/week, 6–8 weeks

No

NR

After every 3rd training session: If either self-selected velocity or maximum velocity increased by at least 10% compared with the last assessment, the training speed increased by 10%; otherwise, training speed increased by the greater (%) of the two. If a decrease in either self-selected velocity or maximum velocity occurred, no change in training speed was implemented.

Kleffelgaard et al. 2019 [53]

Structured Gait/ Balance/ Functional Exercise

Vestibular Rehab & PA

Yes (Physiotherapist)

NR

2*/week, 8 weeks (duration NR)

Yes (2–5)

Metropolitan University

Feedback from each patient during the group sessions and their exercise diary was used to determine the parameters of the exercises throughout the intervention period. Resolution of increased symptoms within 15-30-min after the exercise session was used as a general guideline for modification and progression of the exercises. The PA was completed at home and included individually modified exercises such as walking, biking, and skiing

Särkämö et al. 2021 [55]

Structured Gait/ Balance/ Functional Exercise

Dance-Based Rehab

Yes (Dance teacher and a Physiotherapist)

NR

60-min, 2*/week, 12 weeks

No

Specialised Rehab Centre

Exercises are progressed depending on individual progress and can be done sitting or standing, alone or supported and the difficulty level and the number and type of each exercise/movement can be adjusted.

Community-based

Blake et al. 2009 [37]

Sport & Physical Recreation

Tai Chi Qigong

Yes (Qigong Instructor)

NR

60-min, 1*/week, 8 weeks

Yes (unclear)

Community Day Centre

NR

Brenner et al. 2012 [38]

Promotion Overall PA

Health and Wellness Therapy Group

Yes (Allied Health Facilitators)

NA

90-min, 1*/week, 12 weeks

Yes (7–8)

Veterans Medical Centre

NA

Driver et al. 2004 [43]

Structured Multicomponent Exercise

Aquatics programme

Yes (Instructor – qualifications not specified)

50-70% HRR

60-min, 3*/week, 8 weeks

Yes (8, but 1-on-1 instruction)

Local swimming pool

Participants wore a HR monitor throughout sessions and were instructed to stay between 50-70% of HRR

Driver et al. 2006 [44]

Structured Multicomponent Exercise

Aquatics programme

Yes (Instructor – qualifications not specified)

50-70% HRR

60-min, 3*/week, 8 weeks

Yes (9, but 1-on-1 instruction)

Local swimming pool

Participants wore a HR monitor throughout sessions and were instructed to stay between 50-70% of HRR

Driver et al. 2009 [45]

Structured Multicomponent Exercise

Aquatics programme

Yes (Instructor – qualifications not specified)

50-70% HRR

60-min, 3*/week, 8 weeks

Yes (8, but 1-on-1 instruction)

Local swimming poola

Participants wore a HR monitor throughout sessions and were instructed to stay between 50-70% of HRR

Gemmell et al. 2006 [48]

Sport & Physical Recreation

Tai Chi

Yes (Tai Chi Instructor)

NR

45-min, 2*/week, 6 weeks

Yes (9)

NR

The course consisted of various Tai Chi basics, including breathing and stepping techniques and five forms from the 38-step frame.

Hassett et al. 2009 [49]

Structured Multicomponent Exercise

Aerobic and muscle strength training

Yes (Personal Trainer)

Aerobic: Moderate-intensity, symptom limited such that they were breathing hard but able to talk.

Strength: 6 muscle groups targeted, 3*10 or 2*15 sets/repetitions

60-min, 3*/week, 12 weeks

No

Local fitness centre

The personal trainer determined how

best to complete and progress the exercises.

McMillan et al. 2002 [54]

Structured Aerobic Exerciseb

Physical Exercise

Yes (the 5*45-min sessions were supervised by a therapist)

NR

5*45-min sessions over 4 weeks supervised & daily independent practice (duration NR)

Unclear

NR

NR

Home-based

Bellon et al. 2015 [35] & Kolakowsky-Hayner et al. 2017 [36]

Promotion Overall PA

Walking

Yes (Remote supervision by a Research Assistant/Coach)

NR

7*/week, 12 weeks (no daily time limit)

No

Participant’s home

Participants were given the goal of a 5% increase in daily steps over their individual baseline for the first week. In subsequent weeks, the daily step goal was increased by the same number of steps until the participant reached a 40% increase in week eight and maintained the 40% increase over baseline for the last four weeks of the study.

Katz-Leurer et al. 2009 [52]

Structured Gait/ Balance/ Functional Exercise

Sit-to-Stands and step- ups

Yes (Parents)

Weeks 1–2: 50% max performance; Weeks 3–6: up to 75% max performance (max performance = No. sit-to-stands and No. step-ups forward and sideward in 1-min)

15-min, 5*/week, 6 weeks

No

Participant’s home

Increase repetitions

Tefertiller et al. 2019 [57]

Structured Gait/ Balance/ Functional Exercise

VR exercise targeting balance in standing

Yes (Physiotherapist)

Basic, intermediate, and advanced

30-min, 3–4*/week, 12 weeks

No

Participant’s home

Following week six testing, exercise difficulty was updated based on Community Balance and Mobility scale stratification.

Inpatient & Outpatient Rehab

Hassett et al. 2012 [51]

Structured Multicomponent Exercise

Circuit class with HR feedback

Yes (Physiotherapy

undergraduate students, Physiotherapy assistants, Physiotherapists)

HR training zone was calculated as ≥ 50% HRR using the Karvonen equation

60-min, 3*/week, 2 weeks

Yes (average of 8, but up to 14)

Brain Injury Unit Gym

Supervising staff used the information from the heart rate monitor to provide encouragement regarding the intensity of exercise and to progress exercises where possible (e.g., lowering the height of the chair for the sit-to-stand station).

Straudi et al. 2017 [56]

Structured Gait/ Balance/ Functional Exercise

Video game-based exercise targeting balance in standing

Yes (Physiotherapist)

NR

60-min, 3*/week, 6 weeks

No

University Hospital

Each video game had a progression over time according to patients’ abilities and successes.

  1. PA Physical activity, HRmax Heart rate maximum, HR Heart rate, BWS Body-weight supported, NR Not reported, VR Virtual reality, Rehab Rehabilitation, NA Not applicable, HRR Heart rate reserve, Max Maximum, No., Number of
  2. a In Driver et al. [45], while the location of the intervention is not explicitly stated in the article, given the intervention delivered and the previous work of Driver and colleagues [43, 44], we have determined the most likely location for the intervention in this study is the local swimming pool
  3. b Classification of intervention delivered in McMillan et al. [54] was confirmed via correspondence with author and lead author of the Hassett et al. [59] Cochrane review