Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Table 2 Odds ratios and 95% confidence intervals for the association between nutrient patterns and hyperuricemia

Nutrient patterns	Quartiles of nutrient pattern scores				P-trend
	Q1	Q2	Q3	Q4
	Q1	OR (95% CI)	OR (95% CI)	OR (95% CI)
PCA^a
Lower energy intake
Model 1^c	Ref.	0.79 (0.67, 0.94)	0.88 (0.76, 1.02)	0.88 (0.74, 1.05)	0.296
Model 2^d	Ref.	0.85 (0.70, 1.02)	1.01 (0.85, 1.20)	1.04 (0.88, 1.24)	0.267
Model 3^e	Ref.	0.84 (0.68, 1.03)	1.01 (0.78, 1.29)	1.00 (0.73, 1.37)	0.459
Low vitamin A, C, K pattern
Model 1^c	Ref.	1.07 (0.89, 1.29)	1.20 (1.01, 1.42)	1.25 (1.03, 1.52)	0.009
Model 2^d	Ref.	1.04 (0.87, 1.25)	1.16 (0.97, 1.39)	1.22 (0.98, 1.52)	0.036
Model 3^e	Ref.	1.01 (0.84, 1.22)	1.12 (0.93, 1.34)	1.17 (0.93, 1.46)	0.104
Vitamin B group
Model 1^c	Ref.	0.84 (0.70, 1.02)	0.74 (0.62, 0.89)	0.63 (0.51, 0.77)	< 0.001
Model 2^d	Ref.	0.82 (0.67, 0.99)	0.74 (0.62, 0.88)	0.63 (0.51, 0.77)	< 0.001
Model 3^e	Ref.	0.81 (0.67, 0.99)	0.75 (0.63, 0.89)	0.63 (0.51, 0.77)	< 0.001
RRR^b
High fat and low vitamin diet
Model 1^c	Ref.	1.09 (0.92, 1.29)	1.27 (1.10, 1.46)	1.37 (1.18, 1.58)	< 0.001
Model 2^d	Ref.	1.11 (0.93, 1.32)	1.27 (1.09, 1.48)	1.32 (1.14, 1.52)	< 0.001
Model 3^e	Ref.	1.00 (0.84, 1.19)	1.14 (0.97, 1.32)	1.23 (1.06, 1.41)	< 0.001

^aPCA is the method of principal component analysis and included the “Lower energy intake”, “Low vitamin A, C, K pattern” and “Vitamin B group” nutrient patterns
^bRRR stands for reduced rank regression and included the “High fat and low vitamin diet” pattern, which was related to obesity
^cModel 1 was the crude model
^dModel 2 was adjusted for age, race, and sex
^eModel 3 was further adjusted for smoking, drinking, vigorous physical activity, pox ratio, creatinine level, energy intake, history of diabetes, hypertension, cardiovascular diseases, cancer, liver disease and dyslipidaemia

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