Family history of CVD | No. of participants | Myocardial infarction | Early-onset myocardial infraction | |||||
---|---|---|---|---|---|---|---|---|
No. of MI | Hazard Ratio 1 (95% CI) | Hazard Ratio 2 (95% CI) | No. of early-onset MI 1 | Hazard Ratio 1 (95% CI) | Hazard Ratio 2 (95% CI) | |||
Negative | ||||||||
None | 20,002 | 117 | 1.00 | 1.00 | 68 | 1.00 | 1.00 | |
DM | 945 | 17 | 3.10 (1.86–5.16) | 2.09 (1.25–3.48) | 4 | 1.27 (0.46–3.47) | 1.55 (0.56–4.25) | |
HTN | 18,095 | 237 | 2.27 (1.82–2.83) | 1.59 (1.27–1.99) | 109 | 1.80 (1.33–2.43) | 2.09 (1.54–2.86) | |
DLP | 8,357 | 94 | 1.99 (1.51–2.61) | 1.60 (1.22–2.10) | 46 | 1.67 (1.15–2.43) | 1.86 (1.28–2.72) | |
DM and HTN | 1,944 | 46 | 4.17 (2.96–5.86) | 2.27 (1.60–3.22) | 16 | 2.52 (1.46–4.34) | 3.29 (1.88–5.76) | |
DM and DLP | 945 | 24 | 4.54 (2.93–7.04) | 2.86 (1.83–4.45) | 3 | 0.99 (0.31–3.13) | 1.25 (0.39–3.99) | |
HTN and DLP | 13,008 | 232 | 3.19 (2.56–3.99) | 2.02 (1.61–2.55) | 79 | 1.88 (1.36–2.60) | 2.32 (1.65–3.27) | |
DM, HTN, and DLP | 2,753 | 65 | 4.37 (3.23–5.92) | 2.58 (1.90–3.50) | 27 | 3.13 (2.00-4.89) | 4.11 (2.57–6.57) | |
Positive | ||||||||
None | 4,354 | 31 | 1.23 (0.83–1.83) | 1.32 (0.89–1.95) | 20 | 1.37 (0.83–2.25) | 1.32 (0.80–2.17) | |
DM | 176 | 2 | 1.99 (0.49–8.04) | 1.38 (0.34–5.58) | 2 | 3.41 (0.84–13.9) | 3.95 (0.97–16.13) | |
HTN | 4,401 | 67 | 2.70 (2.00-3.65) | 2.03 (1.51–2.74) | 37 | 2.57 (1.72–3.83) | 2.88 (1.92–4.32) | |
DLP | 1,943 | 22 | 2.01 (1.27–3.16) | 1.68 (1.07–2.66) | 15 | 2.35 (1.34–4.11) | 2.49 (1.42–4.37) | |
DM and HTN | 421 | 8 | 3.48 (1.70–7.13) | 1.98 (0.96–4.06) | 3 | 2.26 (0.71–7.17) | 2.96 (0.93–9.48) | |
DM and DLP | 160 | 4 | 4.64 (1.71–12.6) | 3.24 (1.19–8.79) | 3 | 5.98 (1.88–18.99) | 7.36 (2.30-23.52) | |
HTN and DLP | 3,555 | 84 | 4.35 (3.29–5.76) | 2.90 (2.18–3.86) | 35 | 3.13 (2.08–4.70) | 3.69 (2.43–5.62) | |
DM, HTN, and DLP | 744 | 25 | 6.40 (4.15–9.85) | 3.74 (2.45–5.71) | 12 | 5.30 (2.87–9.79) | 6.73 (3.59–12.63) |