Table 1 Description of two different HBV case definitions based on serological markers. HBV Class 1 refers to international HBV status classification. HBV Class 2 refers to a modified classification proposed by the authors in order to maximize available data for analysis

HBV Infection

Any serological marker for HBV Infection

Any serological marker for HBV Infection

Acute

HBsAg positive and

Anti-HBc IgM positive and

Anti-HBc total positive

HBsAg positive and

Anti-HBc IgM positive

Chronic

HBsAg positive and

Anti-HBc IgM negative and

Anti-HBc total positive

HBsAg positive and

(Anti-HBs negative or undetermined or not informed)

Resolved

Anti-HBs positive and

Anti-HBc total positive

(Anti-HBc total positive or Anti-HBs positive) and (HBsAg negative or undetermined or not informed)