Table 2 Incidence rates and 95% confidence intervals of pneumococcal-specific meningitis, bacteremia, bacteremic pneumonia, and other IPD, among commercially insured children aged < 18 years, in episodes per 100,000 person-years, by PCV period (1998–2018)^a,b

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

Pre-PCV7

9.38

(7.96; 11.04)

2.56

(1.87; 3.50)

4.20

(3.29; 5.36)

2.29

(1.65; 3.19)

0.33

(0.14; 0.77)

65.58

(52.97; 81.18)

16.39

(10.72; 25.06)

33.57

(24.92; 45.21)

14.05

(8.89; 22.21)

1.56

(0.43; 5.69)

Early PCV7

4.27

(3.97; 4.58)

0.84

(0.71; 0.99)

2.06

(1.86; 2.28)

1.18

(1.03; 1.35)

0.19

(0.13; 0.26)

22.68

(20.43; 25.18)

4.01

(3.13; 5.14)

14.15

(12.40; 16.15)

4.20

(3.30; 5.35)

0.32

(0.14; 0.76)

Late PCV7

4.85

(4.61; 5.10)

0.83

(0.73; 0.94)

2.22

(2.06; 2.40)

1.67

(1.53; 1.82)

0.13

(0.09; 0.17)

24.93

(23.13; 26.87)

4.32

(3.61; 5.17)

14.72

(13.35; 16.23)

5.64

(4.81; 6.60)

0.26

(0.12; 0.53)

Early PCV13

2.95

(2.77; 3.15)

0.59

(0.51; 0.69)

1.21

(1.10; 1.34)

1.00

(0.90; 1.12)

0.14

(0.10; 0.19)

12.72

(11.44; 14.14)

2.19

(1.70; 2.83)

7.33

(6.37; 8.42)

2.68

(2.13; 3.37)

0.52

(0.31; 0.87)

Late PCV13

2.75

(2.57; 2.94)

0.60

(0.52; 0.69)

1.13

(1.02; 1.26)

0.81

(0.72; 0.92)

0.20

(0.16; 0.26)

11.61

(10.41; 12.94)

2.72

(2.18; 3.41)

5.98

(5.14; 6.96)

2.36

(1.86; 3.01)

0.54

(0.33; 0.89)

Ages 2–4

Ages 5–17

Period

Overall IPD

Meningitis

Bacteremia

Bacteremic

pneumonia

Other IPD

Overall IPD

Meningitis

Bacteremia

Bacteremic

pneumonia

Other IPD

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

IR

(95% CI)

Pre-PCV7

13.89

(9.67; 19.95)

2.40

(1.02; 5.61)

6.71

(3.99; 11.26)

4.31

(2.27; 8.19)

0.48

(0.08; 2.71)

2.52

(1.77; 3.60)

1.09

(0.64; 1.87)

0.59

(0.29; 1.22)

0.67

(0.34; 1.33)

0.17

(0.05; 0.61)

Early PCV7

5.89

(5.03; 6.91)

1.05

(0.72; 1.53)

2.69

(2.13; 3.41)

2.07

(1.58; 2.71)

0.08

(0.02; 0.28)

1.85

(1.63; 2.09)

0.44

(0.34; 0.56)

0.55

(0.44; 0.70)

0.67

(0.54; 0.82)

0.19

(0.13; 0.28)

Late PCV7

6.67

(5.96; 7.47)

1.11

(0.84; 1.47)

2.29

(1.89; 2.78)

3.14

(2.66; 3.70)

0.13

(0.06; 0.29)

2.12

(1.94; 2.31)

0.36

(0.29; 0.45)

0.73

(0.63; 0.85)

0.92

(0.80; 1.05)

0.11

(0.07; 0.16)

Early PCV13

3.62

(3.10; 4.22)

0.40

(0.25; 0.63)

1.28

(0.99; 1.65)

1.83

(1.48; 2.27)

0.11

(0.05; 0.26)

1.71

(1.55; 1.88)

0.45

(0.37; 0.54)

0.50

(0.42; 0.60)

0.65

(0.56; 0.76)

0.10

(0.07; 0.15)

Late PCV13

3.70

(3.18; 4.31)

0.58

(0.40; 0.85)

1.45

(1.14; 1.85)

1.56

(1.24; 1.97)

0.11

(0.05; 0.26)

1.54

(1.39; 1.70)

0.36

(0.29; 0.44)

0.51

(0.43; 0.61)

0.49

(0.41; 0.59)

0.18

(0.13; 0.24)