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Table 1 Trends in Age-Adjusted Thyroid Cancer Incidence Rates by Demographic factors, 2000–2017

From: Thyroid cancer incidence trend and association with obesity, physical activity in the United States

  2000–2017 Incidence Rate cases/100000 PY Trend 1/
Trend 3
Trend 2/
Trend 4
2000–2017
Demographic factors No of new cases Age adjusted/ 100 000 (95% CI) 2000 2009 2015 2017 Years APC (95%CI) P Value Years APC (95%CI) P Value AAPC (95%CI) P Value
Overall 683,157 12.1(12.1,12.1) 7.4 13.6 14.7 13.2 2000–2009 7.3a (6.8, 7.7)  < 0.001 2009–2015 1.6a (0.9, 2.3)  < 0.001 3.6a (3.2, 4.1)  < 0.05
        2015–2017 -5.8a (-8.7, -2.8) 0.002      
Sex
 Female 514,414 17.9(17.8,17.9) 10.9 20.1 21.8 19.4 2000–2009 7.2a (7.0, 7.5)  < 0.001 2009–2012 2.3a (0.6, 4.2) 0.017 3.6a (3.2, 4.0)  < 0.05
        2012–2015 0.5 (-1.1, 2.2) 0.468 2015–2017 -5.6a (-7.3, -3.9)  < 0.001   
 Male 168,743 6.2(6.1,6.2) 3.9 6.9 7.4 6.9 2000–2009 6.9a (6.2, 7.7)  < 0.001 2009–2014 2.0a (0.4, 3.7) 0.021 3.8a (3.1, 4.5)  < 0.05
        2014–2017 -2.3 (-4.8, 0.2) 0.068      
Race/ethnicity
 AI/AN 3719 9.0 (8.7,9.3) 4.8 9.6 11.2 10.8 2000–2013 7.3a (6.1, 8.6)  < 0.001 2013–2017 -1.7 (-6.7, 3.6) 0.493 5.1a (3.7, 6.6)  < 0.05
 API 37,351 13.2 (13.0,13.3) 8.6 14.1 15.9 14.3 2000–2003 2.3a (0.4, 4.3) 0.025 2003–2009 7.4a (6.7, 8.1)  < 0.001 3.1a (2.7, 3.5)  < 0.05
        2009–2014 2.8a (2.1–3.5)  < 0.001 2014–2017 -3.9a (-4.9, -2.8)  < 0.001   
 Blacks 49,909 7.8 (7.7,7.9) 4.9 8.5 9.6 8.1 2000–2013 5.8a (5.2, 6.5)  < 0.001 2013–2017 -5.4a (-8.0, -2.6) 0.001 3.1a (2.3, 3.9)  < 0.05
 Whites 506,759 12.9 (12.9,13.0) 7.9 14.8 15.8 14.2 2000–2009 7.5a (7.1, 8.0)  < 0.001 2009–2015 1.3a (0.5, 2.1) 0.003 3.7a (3.2–4.2)  < 0.05
        2015–2017 -5.7a (-8.9, -2.3) 0.004      
 Hispanic 77,526 11.4 (11.3,11,5) 7.0 12.1 13.8 12.9 2000–2009 6.3a (5.5, 7.1)  < 0.001 2009–2015 2.5* (1.1, 3.8) 0.002 3.7a (2.9–4.6)  < 0.05
        2015–2017 -3.4 (-8.7, 2.2) 0.199      
Age (years)
 < 30 68,650 2.9 (2.9–2.9) 2.1 3.0 3.5 3.3 2000–2015 3.8a (3.5, 4.2)  < 0.001 2015–2017 -5.5 (-12.4, 1.9) 0.128 2.7a (1.8, 3.6)  < 0.05
 30–44 183,261 16.3 (16.3,16.4) 10.3 17.3 20.8 18.7 2000–2006 6.1a (5.0, 7.2)  < 0.001 2006–2009 8.3a (3.0, 14.0) 0.007 3.6a (2.6, 4.6)  < 0.05
        2009–2015 2.0a (0.9, 3.0) 0.003 2015–2017 -5.3a (-9.5, -0.8) 0.027   
 45–59 229,817 20.8 (20.7–20.9) 12.3 21.8 25.2 22.7 2000–2009 7.5a (7.1, 8.0)  < 0.001 2009–2014 2.0a (0.9, 3.1) 0.002 3.8a (3.4, 4.3)  < 0.05
        2014–2017 -3.6a (-5.3, -1.9) 0.001      
 60–74 150,976 22.3 (22.2–22.5) 12.4 25.6 25.8 23.0 2000–2008 9.4a (8.5, 10.2)  < 0.001 2008–2013 2.1a (0.4, 3.8) 0.018 4.1a (3.4, 4.7)  < 0.05
        2013–2017 -3.5a (-5.0, 2.0)  < 0.001      
 ≥ 75 50,453 15.5 (15.3–15.6) 10.1 17.8 17.3 15.7 2000–2008 7.7a 6.8,8.5)  < 0.001 2008–2014 0.8a (-0.5,2.2) 0.210 3.0a (2.2,3.7)  < 0.05
        2014–2017 -4.7a (-7.6,-1.7) 0.006      
  1. aThe difference was statistically significant