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Table 1 Estimates of parameters used in the model

From: Modelling the prevalence of hepatitis B towards eliminating it as a major public health threat in China

Parameter Base-case value Range Distribution References
λa,t, age- and time-dependent force of HBV infection Table S1 and Figure S2: base-case sets Table S1 and Figure S2: 95% confidence interval sets Uniform  
qa, age-dependent proportion of acute HBV infections that become chronic     [20]
  < 1 year 0.3  ± 20% Uniform (0.24, 0.36)
Uniform (0.2, 0.3)
Uniform (0.048, 0.072)
Uniform (0.032, 0.048)
 
 1 − 5 years 0.25
 6 − 19 years 0.06
  ≥ 20 years 0.04
r, rate of chronic HBV infections that become immune (HBV clearance) 0.01 0.005–0.02 Triangular (0.005, 0.01, 0.02) [21, 22]
dAa, age-dependent mortality of acute HBV infection     Based on the age-specific risks of symptomatic infection and fulminant hepatitis and the fatality rate of fulminant hepatitis [23, 24]
  < 1 year 0.000007  ± 50% Uniform (0.0000035, 0.0000105)  
 1 − 5 years 0.00042 Uniform (0.00021, 0.00063)
  ≥ 6 years 0.00126 Uniform (0.00063, 0.00189)
dCa, age-dependent mortality of cirrhosis Age-specific HBV-related cirrhosis mortality curve  ± 50% Uniform [23]
dHa, age-dependent mortality of hepatocellular carcinoma Age-specific HBV-related hepatocellular carcinoma mortality curve  ± 50% Uniform [23]
vt, vaccine coverage of newborns in 2006 and beyond 0.94 0.9 − 0.98 Normal (0.94, 0.020408) [12,13,14,15]
pt, vaccine protection against HBV infection in 2006 and beyonda 0.95 0.92 − 0.98 Normal (0.95, 0.015306) [16,17,18]
θa,t, catch-up vaccine coverage during 2009 − 2011 in children born between 1994 and 2001 who missed the routine vaccination 0.95 0.9 − 0.97 Uniform (0.9, 0.97) [25]
ε, HBV intrauterine infection rate in infected pregnant women 0.03 0.02 − 0.035 Triangular (0.02, 0.03, 0.035) [26,27,28]
  1. aAlso be used in the catch-up vaccination during 2009 − 2011