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Table 2 Characteristics of Indigenous-Australian trials compared to general Australian trials

From: Landscape of clinical trial activity focusing on Indigenous health in Australia: an overview using clinical trial registry data from 2008-2018

 

Indigenous Australian trials

n (%)

General Australian trials

n (%)

Total number of trials

139

9067

Size

 Total number of participants

155,694

2,561,337a

 Median sample size

250 (IQR 100–535)

60 (IQR30–140)

Public Health Involvement

 Public Health-related

59 (42%)

958 (11%)

 Non-public health related

80 (58%)

8109 (89%)

Allocation

 Randomised

97 (70%)

6666 (74%)

 Non-randomised

41 (30%)

2148 (24%)

 Missing

1 (0%)

253 (3%)

Masking

 Blinded

48 (35%)

4273 (47%)

 Open

76 (55%)

3935 (43%)

 Missing

15 (10%)

859 (9%)

Intervention typesb

 Treatment: any

72 (52%)

6785 (75%)

 Prevention

48 (36%)

1343 (15%)

 Behaviour

41 (30%)

1542 (17%)

 Treatment: Other

35 (26%)

2465 (27%)

 Lifestyle

26 (19%)

1016 (11%)

 Treatment: Drugs

23 (17%)

2689 (30%)

 Early detection / Screening

18 (13%)

298 (3%)

 Other interventions

15 (11%)

618 (7%)

 Treatment: Devices

7 (5%)

1270 (14%)

 Treatment: Surgery

7 (5%)

361 (4%)

 Rehabilitation

5 (4%)

728 (8%)

 Diagnosis / Prognosis

3 (2%)

289 (3%)

 Not applicable

0 (0%)

3 (0%)

Primary Sponsorc

 University

72 (53%)

2699 (33%)

 Individual

16 (12%)

1882 (23%)

 Government body

14 (10%)

315 (4%)

 Other

13 (10%)

249 (3%)

 Charities/Societies/Foundations

8 (6%)

272 (3%)

 Other Collaborative groups

6 (4%)

227 (3%)

 Hospital

3 (2%)

1619 (20%)

 Commercial sector/Industry

3 (2%)

868 (11%)

Fundingd

 Government body

107 (79%)

1930 (21%)

 Charities/Societies/Foundations

19 (14%)

1542 (17%)

 University

11 (8%)

1678 (18%)

 Commercial sector/Industry

9 (7%)

1587 (17%)

 Other Collaborative groups

7 (5%)

295 (3%)

 Hospital

6 (4%)

1238 (13%)

 Other

3 (2%)

241 (3%)

 Self-funded/Unfunded

2 (1%)

759 (8%)

  1. a Two outliers were eliminated, each with participant size > 100,000 to avoid skewing of results and minimise misinterpretation of the mean recruitment size between Indigenous and General Australian trials
  2. b Percentage calculations were adjusted by the total number of trials, not the number of entries for intervention as each trial could list up to three intervention codes
  3. c Used ANZCTR data only, as CTgov had no data field for sponsorship
  4. d Used ANZCTR data only, as CTgov had fewer categories that could skew results. Each study could list up to 20 entries