EORTC QLQ-C30 general population normative data for Italy by sex, age and health condition: an analysis of 1,036 individuals

Pilz, Micha J.; Gamper, Eva-Maria; Efficace, Fabio; Arraras, Juan I.; Nolte, Sandra; Liegl, Gregor; Rose, Matthias; Giesinger, Johannes M.

doi:10.1186/s12889-022-13211-y

Table 5 EORTC QLQ-C30 reference values for general population of Italy by age, sex, and health condition

From: EORTC QLQ-C30 general population normative data for Italy by sex, age and health condition: an analysis of 1,036 individuals

	Women
	18–39 years				40-49 years				50-59 years				60-69 years				70 + years				Total
	one or more health conditions N = 81		no health condition N = 62		one or more health conditions N = 62		no health condition N = 29		one or more health conditions N = 54		no health condition N = 34		one or more health conditions N = 49		no health condition N = 26		one or more health conditions N = 78		no health condition N = 31		one or more health conditions N = 325		no health condition N = 181
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Physical Functioning	80.54	19.07	92.04	11.10	80.50	17.66	93.76	7.09	80.55	14.99	92.81	8.56	76.61	15.96	90.51	11.60	76.27	18.78	89.14	16.51	78.92	17.66	91.74	11.36
Social Functioning	82.11	25.05	95.68	13.81	75.87	26.01	98.39	6.61	78.42	25.91	96.93	9.39	84.92	19.61	99.49	2.91	86.76	18.09	98.77	4.44	81.84	23.34	97.41	9.70
Role Functioning	77.88	27.71	95.44	12.10	78.36	26.92	97.31	6.24	79.23	21.68	96.93	9.39	76.19	23.57	95.96	13.26	79.90	25.82	90.12	21.26	78.43	25.45	95.18	13.30
Emotional Functioning	60.14	23.32	80.48	21.87	54.23	24.39	84.14	15.59	62.98	18.44	80.26	14.45	70.50	21.78	84.85	13.48	74.14	20.04	84.88	16.95	64.41	22.86	82.39	17.75
Cognitive Functioning	81.52	20.71	93.22	13.05	78.11	24.32	91.94	13.54	81.15	20.32	90.35	14.85	80.69	21.47	92.42	10.33	88.48	16.08	91.36	10.69	82.36	20.72	92.05	12.68
Global health status / QOL	56.45	21.10	76.57	14.22	51.00	21.51	76.88	16.37	50.55	19.14	74.12	15.50	54.23	18.24	78.28	13.71	57.97	18.22	74.07	15.35	54.45	19.88	75.98	14.86
Fatigue	46.22	22.45	17.86	19.43	42.95	24.78	18.64	18.48	38.43	21.74	16.37	16.52	34.57	22.99	16.50	16.30	30.23	20.37	18.52	24.40	38.69	23.10	17.63	19.15
Nausea / Vomiting	12.65	19.54	5.68	14.45	15.67	20.30	2.69	7.58	9.02	15.41	0.88	5.42	4.23	11.21	0.51	2.91	4.90	12.56	2.47	10.00	9.49	16.94	3.04	10.36
Pain	32.15	27.80	8.38	15.00	31.09	27.22	6.99	12.76	31.69	23.54	5.70	11.17	30.69	26.70	8.59	16.28	26.47	25.93	14.81	23.66	30.28	26.33	8.80	16.19
Dyspnoea	27.34	24.83	6.45	14.57	28.86	29.54	8.60	17.16	25.68	22.30	6.14	13.12	19.05	23.02	6.06	15.56	17.65	24.73	11.11	27.66	23.77	25.40	7.48	17.69
Insomnia	35.10	28.63	10.30	16.65	36.32	27.68	17.20	25.67	34.43	30.44	24.56	24.16	30.69	28.97	15.15	18.89	21.57	22.11	14.81	21.30	31.30	27.82	15.50	21.23
Appetite loss	14.26	26.31	2.72	10.99	19.90	26.00	0.00	0.00	13.66	21.43	5.26	12.34	8.47	15.84	6.06	15.56	8.33	17.62	2.47	8.87	12.95	22.46	3.19	10.88
Constipation	23.52	25.02	8.70	18.17	24.88	32.50	12.90	18.64	16.94	26.99	12.28	22.53	14.81	23.07	10.10	15.63	12.75	23.03	6.17	20.70	18.78	26.55	9.80	19.17
Diarrhoea	12.49	23.23	5.39	16.17	15.42	22.73	6.45	15.93	13.11	22.20	3.51	10.39	11.64	20.05	1.01	5.83	7.84	17.37	0.00	0.00	11.91	21.23	3.67	12.56
Financial Problems	11.72	24.99	2.72	10.99	17.91	27.43	5.38	12.48	18.03	30.81	3.51	10.39	16.40	26.75	1.01	5.83	11.76	23.56	3.70	19.20	14.67	26.45	3.22	12.34
Summary Score	75.27	15.22	91.64	9.34	73.23	16.63	91.70	7.74	76.87	13.21	90.97	7.68	79.60	12.75	92.25	6.85	82.76	12.62	91.07	9.17	77.60	14.58	91.51	8.37

	Men
	18–39 years				40–49 years				50–59 years				60–69 years				70 + years				Total
	one or more health conditions N = 70		no health condition N = 93		one or more health conditions N = 52		no health condition N = 35		one or more health conditions N = 50		no health condition N = 34		one or more health conditions N = 49		no health condition N = 20		one or more health conditions N = 53		no health condition N = 25		one or more health conditions N = 275		no health condition N = 207
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Physical Functioning	74.30	25.45	94.12	9.22	82.38	18.67	97.19	4.56	83.56	15.33	95.56	6.38	82.10	16.60	95.17	7.38	81.82	16.59	94.19	7.68	80.38	19.60	94.99	7.81
Social Functioning	75.54	27.42	93.77	16.19	76.79	24.15	96.93	8.55	87.93	19.22	95.73	11.31	85.48	20.11	100.00	0.00	90.66	18.55	97.85	8.36	82.76	23.24	95.73	12.70
Role Functioning	72.85	27.45	94.44	10.72	77.08	26.72	99.12	3.78	83.91	24.00	95.30	11.46	84.76	24.44	98.28	5.20	87.63	18.60	95.70	12.19	80.68	25.10	95.91	9.88
Emotional Functioning	61.56	27.96	79.85	23.84	64.14	22.26	85.96	13.17	72.41	20.81	76.92	18.52	79.05	17.36	89.66	11.80	82.83	13.73	89.78	11.97	71.30	22.96	82.58	19.68
Cognitive Functioning	77.24	27.39	91.33	17.60	80.65	21.52	96.93	7.62	87.93	16.18	92.74	11.36	85.95	16.75	94.25	11.24	89.65	12.69	93.55	9.34	83.81	20.64	93.07	13.92
Global health status / QOL	59.81	19.65	74.33	18.92	58.33	21.39	78.51	15.59	58.76	17.99	75.43	15.32	58.57	19.30	80.17	14.96	69.57	15.60	79.57	17.53	61.01	19.26	76.43	17.29
Fatigue	41.99	27.56	24.30	22.20	38.69	25.35	14.62	15.32	29.89	21.17	15.67	15.05	28.57	21.85	7.66	12.37	22.56	20.38	6.45	10.29	32.97	24.67	17.44	19.18
Nausea / Vomiting	16.85	26.97	5.76	19.16	9.82	18.21	1.32	5.99	4.60	13.55	0.00	0.00	2.86	10.64	0.57	3.12	0.51	2.88	1.08	6.01	7.60	18.37	2.98	13.43
Pain	33.51	24.37	14.02	20.01	31.85	26.66	8.33	15.87	20.69	22.61	7.26	12.59	18.81	23.11	3.45	10.41	14.39	17.79	3.23	6.72	24.50	24.25	9.60	16.70
Dyspnoea	28.49	26.41	6.50	16.90	19.64	24.45	7.02	13.79	15.52	20.94	5.13	12.21	19.05	25.82	3.45	10.41	13.13	20.19	6.45	13.44	19.77	24.34	6.06	14.65
Insomnia	32.97	33.58	14.36	25.49	36.31	30.69	13.16	22.67	24.14	24.85	14.53	23.98	19.52	24.48	8.05	17.16	14.14	22.73	5.38	12.51	25.92	29.03	12.47	22.85
Appetite loss	17.93	26.78	5.55	20.06	10.71	16.96	2.63	9.12	8.62	17.19	0.85	5.35	7.14	18.79	1.15	6.24	6.06	14.24	1.08	6.01	10.62	20.22	3.31	14.47
Constipation	23.12	31.68	7.59	16.72	21.43	24.98	5.26	12.33	10.92	19.16	6.84	15.66	16.19	24.64	1.15	6.24	17.68	22.09	5.38	12.51	18.27	25.57	6.17	14.63
Diarrhoea	21.50	31.20	10.43	21.25	14.88	21.96	4.39	11.43	8.62	16.01	1.71	7.46	5.71	15.03	2.30	8.66	7.07	14.95	2.15	8.36	12.26	22.40	6.17	16.17
Financial Problems	18.28	29.14	1.90	9.36	18.45	22.86	0.88	5.41	11.49	22.15	2.56	9.02	13.33	25.07	2.30	8.66	9.09	18.10	1.08	6.01	14.40	24.23	1.77	8.27
Summary Score	72.70	22.49	89.62	12.96	76.75	15.79	93.80	5.14	84.06	13.10	92.63	6.44	84.58	13.05	96.12	4.37	87.46	9.26	95.38	5.61	80.54	16.85	92.16	9.86

	Total
	18–39 years				40–49 years				50–59 years				60–69 years				70 + years				Total
	one or more health conditions N = 151		no health condition N = 155		one or more health conditions N = 115		no health condition N = 64		one or more health conditions N = 104		no health condition N = 67		one or more health conditions N = 98		no health condition N = 46		one or more health conditions N = 132		no health condition N = 56		one or more health conditions N = 600		no health condition N = 389
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Physical Functioning	77.65	22.39	93.28	10.04	81.35	18.07	95.65	6.03	82.01	15.15	94.19	7.61	79.37	16.43	92.58	10.12	78.52	18.07	91.39	13.45	79.59	18.58	93.48	9.75
Social Functioning	79.07	26.30	94.54	15.26	76.29	25.08	97.58	7.71	83.02	23.30	96.32	10.34	85.20	19.76	99.72	2.17	88.34	18.31	98.36	6.44	82.26	23.28	96.52	11.42
Role Functioning	75.55	27.61	94.85	11.27	77.78	26.72	98.31	5.07	81.49	22.84	96.11	10.44	80.50	24.27	96.99	10.44	83.03	23.40	92.61	17.87	79.46	25.29	95.57	11.59
Emotional Functioning	60.80	25.50	80.10	23.00	58.74	23.86	85.14	14.22	67.54	20.09	78.58	16.58	74.80	20.05	86.98	12.85	77.66	18.21	87.07	15.01	67.57	23.14	82.49	18.78
Cognitive Functioning	79.54	24.05	92.09	15.91	79.27	23.02	94.68	10.89	84.43	18.66	91.55	13.17	83.33	19.33	93.24	10.66	88.95	14.76	92.34	10.08	83.03	20.68	92.60	13.35
Global health status / QOL	58.01	20.44	75.23	17.17	54.33	21.67	77.78	15.84	54.52	18.95	74.78	15.31	56.41	18.81	79.12	14.15	62.67	18.07	76.53	16.44	57.46	19.85	76.22	16.18
Fatigue	44.26	24.95	21.71	21.30	41.01	25.02	16.43	16.80	34.30	21.79	16.02	15.68	31.55	22.51	12.57	15.19	27.12	20.65	13.13	20.19	36.07	23.98	17.53	19.14
Nausea / Vomiting	14.59	23.29	5.73	17.37	13.01	19.51	1.93	6.73	6.88	14.64	0.44	3.82	3.54	10.89	0.54	2.97	3.12	10.07	1.85	8.41	8.62	17.62	3.01	12.08
Pain	32.78	26.19	11.75	18.32	31.44	26.85	7.73	14.46	26.37	23.64	6.49	11.84	24.72	25.54	6.30	14.07	21.57	23.66	9.64	18.94	27.63	25.54	9.22	16.45
Dyspnoea	27.87	25.50	6.48	15.96	24.66	27.61	7.73	15.29	20.77	22.14	5.63	12.58	19.05	24.34	4.90	13.44	15.82	23.02	9.03	22.40	21.93	24.98	6.72	16.13
Insomnia	34.12	30.93	12.73	22.39	36.31	28.96	14.98	23.95	29.45	28.22	19.52	24.42	25.08	27.25	11.99	18.29	18.56	22.58	10.60	18.39	28.83	28.48	13.88	22.13
Appetite loss	15.96	26.50	4.42	17.02	15.72	22.72	1.45	6.85	11.22	19.57	3.05	9.68	7.80	17.31	3.88	12.45	7.41	16.31	1.85	7.69	11.88	21.47	3.25	12.90
Constipation	23.34	28.20	8.04	17.27	23.31	29.25	8.70	15.82	14.03	23.61	9.54	19.43	15.51	23.76	6.12	13.05	14.74	22.70	5.82	17.38	18.55	26.08	7.86	16.98
Diarrhoea	16.66	27.49	8.40	19.47	15.18	22.29	5.31	13.56	10.94	19.49	2.60	9.01	8.66	17.86	1.58	7.17	7.53	16.38	0.96	5.63	12.07	21.76	5.00	14.63
Financial Problems	14.75	27.09	2.23	10.02	18.16	25.35	2.90	9.47	14.87	27.04	3.03	9.66	14.86	25.83	1.58	7.17	10.68	21.48	2.53	14.78	14.55	25.43	2.45	10.38
Summary Score	74.08	18.91	90.43	11.65	74.83	16.28	92.86	6.47	80.35	13.58	91.81	7.08	82.10	13.08	93.97	6.13	84.66	11.58	92.99	8.02	78.95	15.72	91.86	9.19

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