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Table 3 Multivariable Cox regression of all-cause mortality in relation to independent and joint effects of body mass index and metabolic health status

From: Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality: a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years

Age

Models

Independent effects of BMI

Independent effects of MHS

Joint effects of BMI and MHS

Model 1

Model 2

Model 3

Model 4

Model 5

Model 6

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Adjustments

Sex, Educ, Smoke

 + CVD

Sex, Educ, Smoke

 + CVD

Sex, Educ, Smoke

 + CVD

 <  = 65 years

BMI categories

      

Overweight

1.02 (0.87 – 1.21)

0.99 (0.84 – 1.17)

  

0.96 (0.81 – 1.13)

0.94 (0.80 – 1.12)

Obesity

1.42 (1.16 -1.75)

1.30 (1.06 – 1.60)

  

1.25 (1.003 – 1.55)

1.19 (0.96 – 1.48)

MU status

  

1.43 (1.23 – 1.66)

1.31 (1.12 – 1.53)

1.38 (1.18 – 1.62)

1.28 (1.09 – 1.51)

 > 65 years

BMI categories

      

Overweight

0.99 (0.93 – 1.07)

0.96 (0.89 – 1.03)

  

0.96 (0.89 – 1.03)

0.94 (0.87 – 1.01)

Obesity

1.22 (1.10 – 1.35)

1.15 (1.04 – 1.27)

  

1.15 (1.04 – 1.28)

1.11 (1.01 – 1.23)

MU status

  

1.25 (1.17 – 1.34)

1.18 (1.10 – 1.26)

1.25 (1.16 – 1.33)

1.18 (1.10 – 1.26)

  1. Hazard ratios with 95% confidence intervals from Cox regression models of all-cause mortality in relation to independent effects of body mass index (BMI), metabolic health status (MHS) and joint effects of BMI and MHS. Models 1, 3 and 5 were adjusted for sex, education attainment and smoking status. Models 2, 4 and 6 were adjusted for sex, education attainment, smoking status and history of cardiovascular disease. Bold numbers indicate significance at the α = 0.05 level
  2. Abbreviations: HR hazard ratios, CI confidence interval, Educ education attainment, Smoke smoking status, + CVD additionally adjusted with history of cardiovascular disease, BMI body mass index, MU metabolically unhealthy