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Table 3 Multivariable Cox regression of all-cause mortality in relation to independent and joint effects of body mass index and metabolic health status

From: Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality: a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years

Age Models Independent effects of BMI Independent effects of MHS Joint effects of BMI and MHS
Model 1 Model 2 Model 3 Model 4 Model 5 Model 6
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
Adjustments Sex, Educ, Smoke  + CVD Sex, Educ, Smoke  + CVD Sex, Educ, Smoke  + CVD
 <  = 65 years BMI categories       
Overweight 1.02 (0.87 – 1.21) 0.99 (0.84 – 1.17)    0.96 (0.81 – 1.13) 0.94 (0.80 – 1.12)
Obesity 1.42 (1.16 -1.75) 1.30 (1.06 – 1.60)    1.25 (1.003 – 1.55) 1.19 (0.96 – 1.48)
MU status    1.43 (1.23 – 1.66) 1.31 (1.12 – 1.53) 1.38 (1.18 – 1.62) 1.28 (1.09 – 1.51)
 > 65 years BMI categories       
Overweight 0.99 (0.93 – 1.07) 0.96 (0.89 – 1.03)    0.96 (0.89 – 1.03) 0.94 (0.87 – 1.01)
Obesity 1.22 (1.10 – 1.35) 1.15 (1.04 – 1.27)    1.15 (1.04 – 1.28) 1.11 (1.01 – 1.23)
MU status    1.25 (1.17 – 1.34) 1.18 (1.10 – 1.26) 1.25 (1.16 – 1.33) 1.18 (1.10 – 1.26)
  1. Hazard ratios with 95% confidence intervals from Cox regression models of all-cause mortality in relation to independent effects of body mass index (BMI), metabolic health status (MHS) and joint effects of BMI and MHS. Models 1, 3 and 5 were adjusted for sex, education attainment and smoking status. Models 2, 4 and 6 were adjusted for sex, education attainment, smoking status and history of cardiovascular disease. Bold numbers indicate significance at the α = 0.05 level
  2. Abbreviations: HR hazard ratios, CI confidence interval, Educ education attainment, Smoke smoking status, + CVD additionally adjusted with history of cardiovascular disease, BMI body mass index, MU metabolically unhealthy