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Table 2 Interactive effect analysis of trouble sleeping and depression

From: Interaction between trouble sleeping and depression on hypertension in the NHANES 2005–2018

Trouble sleeping

Depression

Hypertension/Total (n)

Model 1

Model 2

Model 3

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

0

0

10,751/21,488

Ref

  

Ref

  

Ref

  

0

1

551/1,101

0.962

0.814–1.137

0.548

1.183

0.985–1.421

0.071

0.927

0.756–1.137

0.465

1

0

3,975/6,305

1.696

1.558–1.847

 < 0.001

1.437

1.300–1.589

 < 0.001

1.291

1.161–1.436

 < 0.001

1

1

1,028/1,540

2.120

1.800–2.496

 < 0.001

2.298

1.937–2.726

 < 0.001

1.746

1.454–2.098

 < 0.001

RERI (95%CI)

0.461 (0.099–0.823)

0.678 (0.269–1.086)

0.528 (0.182–0.873)

AP (95%CI)

0.217 (0.074–0.361)

0.295 (0.155–0.435)

0.302 (0.140–0.465)

S (95%CI)

1.700 (1.142–2.530)

2.093 (1.359–3.222)

3.413 (1.301–8.951)

  1. Ref reference, RERI relative excess risk due to interaction, AP attributable proportion of interaction, S synergy index, OR odd ratio, CI confidence interval
  2. Model1: unadjusted model
  3. Model2: adjustment for age and gender
  4. Model3: adjustment for age, gender, BMI, race, marital status, education, annual family income, alcohol drinking, smoking history, diabetes, stroke and sleep duration