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Table 2 Interactive effect analysis of trouble sleeping and depression

From: Interaction between trouble sleeping and depression on hypertension in the NHANES 2005–2018

Trouble sleeping Depression Hypertension/Total (n) Model 1 Model 2 Model 3
OR 95% CI P OR 95% CI P OR 95% CI P
0 0 10,751/21,488 Ref    Ref    Ref   
0 1 551/1,101 0.962 0.814–1.137 0.548 1.183 0.985–1.421 0.071 0.927 0.756–1.137 0.465
1 0 3,975/6,305 1.696 1.558–1.847  < 0.001 1.437 1.300–1.589  < 0.001 1.291 1.161–1.436  < 0.001
1 1 1,028/1,540 2.120 1.800–2.496  < 0.001 2.298 1.937–2.726  < 0.001 1.746 1.454–2.098  < 0.001
RERI (95%CI) 0.461 (0.099–0.823) 0.678 (0.269–1.086) 0.528 (0.182–0.873)
AP (95%CI) 0.217 (0.074–0.361) 0.295 (0.155–0.435) 0.302 (0.140–0.465)
S (95%CI) 1.700 (1.142–2.530) 2.093 (1.359–3.222) 3.413 (1.301–8.951)
  1. Ref reference, RERI relative excess risk due to interaction, AP attributable proportion of interaction, S synergy index, OR odd ratio, CI confidence interval
  2. Model1: unadjusted model
  3. Model2: adjustment for age and gender
  4. Model3: adjustment for age, gender, BMI, race, marital status, education, annual family income, alcohol drinking, smoking history, diabetes, stroke and sleep duration