Association between total and leisure time physical activity and risk of myocardial infarction and stroke – a Swedish cohort study

Table 2 Incidence rates and hazard ratios of myocardial infarction for total physical activity

Sex-specific tertiles of total physical activity (METh/day)	Continuous (per 1METh/day increase)	Low	Medium	High	P for linear trend
Male		21.8–34.5	> 34.5–45.8	> 45.8–140.7
Female		22.0–31.7	> 31.7–38.2	> 38.2–128.9
Total
Myocardial infarction
Number of events		599	523	499
Person-years (py)		186,508	189,339	189,636
Event rate per 100,000 py^a		321.2	276.2	263.1
HR (95% CI)^a	1.00 (0.99–1.00)	1.00 (reference)	0.98 (0.87–1.10)	0.96 (0.85–1.08)	0.51
HR (95% CI)^b	1.00 (0.99–1.00)	1.00 (reference)	1.03 (0.91–1.17)	0.95 (0.83–1.08)	0.34
HR (95% CI)^c	1.00 (0.99–1.00)	1.00 (reference)	1.04 (0.91–1.18)	0.96 (0.84–1.10)	0.48
Male
Myocardial infarction
Number of events		302	297	315
Person-years		61,118	61,686	61,840
Event rate per 100,000 py^a		494.1	481.5	509.4
HR (95% CI)^a	1.00 (0.99–1.00)	1.00 (reference)	0.97 (0.83–1.14)	1.08 (0.92–1.26)	0.26
HR (95% CI)^b	1.00 (0.99–1.00)	1.00 (reference)	0.99 (0.84–1.18)	1.06 (0.89–1.26)	0.48
HR (95% CI)^c	1.00 (0.99–1.00)	1.00 (reference)	1.05 (0.88–1.25)	1.12 (0.93–1.34)	0.24
Female
Myocardial infarction
Number of events		297	226	184
Person-years		125,391	127,653	127,797
Event rate per 100,000 py^a		236.9	177.0	144.0
HR (95% CI)^a	1.00 (0.99–1.00)	1.00 (reference)	1.01 (0.85–1.20)	0.82 (0.68–0.98)	0.02
HR (95% CI)^b	1.00 (0.99–1.00)	1.00 (reference)	1.11 (0.92–1.34)	0.82 (0.67–1.00)	0.03
HR (95% CI)^c	0.99 (0.98–0.99)	1.00 (reference)	1.07 (0.88–1.31)	0.78 (0.63–0.97)	0.02

HR Hazard ratio, CI Confidence interval, PY Person-years
^aAdjusted for age and sex at enrollment
^bAdjusted for age, cigarette smoking, alcohol consumption, level of education, and body mass index
^cAdjusted for age, cigarette smoking, alcohol consumption, level of education, body mass index, hypertension, diabetes, and lipid disturbance

ISSN: 1471-2458