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Table 4 Joinpoint trend analysis of liver cancer incidence, mortality, and 1-MIR rates worldwide by age group, 1990–2019

From: Global pattern of trends in incidence, mortality, and mortality-to-incidence ratio rates related to liver cancer, 1990–2019: a longitudinal analysis based on the global burden of disease study

Measure Trend 0–14 15–49 50–69 70+
Year APC (95%CI) Year APC (95%CI) Year APC (95%CI) Year APC (95%CI)
Mortality          
  Trend1 1990–1996 0(−0.30, 0.20) 1990–1996 3.20*(2.70, 3.70) 1990–1996 1.60*(1.30, 2.00) 1990–1996 2.60*(2.40, 2.80)
  Trend2 1996–2000 −3.80*(−4.50, −3.20) 1996–2000 −3.40*(−4.70, −20) 1996–2000 −2.30*(−3.20, −1.40) 1996–2000 −0.20(− 0.70, 0.30)
  Trend3 2000–2003 −7.30*(−8.60, −6.00) 2000–2004 − 13.10*(− 14.30, −11.90) 2000–2004 − 10.40*(− 11.20, −9.60) 2000–2004 −5.50*(−6.00, −5.00)
  Trend4 2003–2007 −1.50*(−2.20, − 0.80) 2004–2007 − 3.20*(−5.80, − 0.50) 2004–2007 −2.60*(− 4.40, − 0.80) 2004–2019 −0.50*(− 0.70, − 0.40)
  Trend5 2007–2012 0.10(− 0.40, 0.50) 2007–2019 −0.20*(− 0.30, 00) 2007–2012 − 1.0*(− 1.60, − 0.50)   
  Trend6 2012–2019 − 1.00*(− 1.20, − 0.80)    2012–2019 0.50*(0.20, 0.70)   
  AAPC 1990–2019 − 1.80*(− 2.00, − 1.60) 1990–2019 − 2.10*(− 2.50, − 1.80) 1990–2019 − 1.80*(− 2.10, − 1.60) 1990–2019 − 0.40*(− 0.50, − 0.30)
Incidence          
  Trend1 1990–1995 0.50*(0.10, 1.00) 1990–1995 3.70*(3.20, 4.10) 1990–1994 2.4*(2.10, 2.7) 1990–1994 3.50*(3.20, 3.80)
  Trend2 1995–2000 −2.50*(− 3.10, − 1.90) 1995–2000 −2.00*(− 2.60, − 1.40) 1994–1998 − 0.40(− 0.80, 0.00) 1994–2000 0.90*(0.700, 1.10)
  Trend3 2000–2004 − 5.50*(− 6.40, − 4.60) 2000–2005 − 11.30*(− 11.90, − 10.80) 1998–2001 − 3.60*(− 4.50, − 2.80) 2000–2005 −4.10*(− 4.40, − 3.80)
  Trend4 2004–2019 − 0.20*(− 0.30, − 0.10) 2005–2019 0.20*(0.10, 0.30) 2001–2005 −9.30*(− 9.70, − 8.90) 2005–2019 0.00(0.00, 0.10)
  Trend5      2005–2011 − 0.80*(− 1.00, − 0.60)   
  Trend6      2011–2019 0.30*(0.30, 0.40)   
  AAPC 1990–2019 − 1.20*(− 1.40, − 1.10) 1990–2019 −1.70*(− 1.90, − 1.50) 1990–2019 −1.50*(− 1.60, − 1.40) 1990–2019 0.00(− 0.10, 0.00)
1-MIR          
  Trend1    1990–1992 8.90(−4.50, 24.20) 1990–1992 10.90*(0.100, 22.90)   
  Trend2    1992–1999 − 3.00*(− 5.10, − 0.80) 1992–1999 − 2.00*(− 3.70, − 0.30)   
  Trend3    1999–2002 23.90*(8.70, 41.20) 1999–2002 35.00*(21.80, 49.50)   
  Trend4    2002–2005 −7.00(−18.40, 6.00) 2002–2006 −6.20*(− 10.90, − 1.30)   
  Trend5    2005–2012 3.80*(1.60, 6.20) 2006–2012 4.20*(1.80, 6.60)   
  Trend6    2012–2019 0.40(−1.30, 2.20) 2012–2019 −0.50(− 1.90, 0.90)   
  AAPC    1990–2019 2.40*(0.30, 4.50) 1990–2019 3.20*(1.70, 4.80)   
  1. APC Annual Percentage Change, AAPC Average Annual Percent Change, CI Confidence Interval, MIR Mortality-to-incidence Ratio 
  2. *Significantly different from 0 at alpha = 0.05 (p < 0.05). There are 1+(number of trend) joinpoints for each model