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Table 3 Age specific incidence, mortality, and 1-MIR rates per 100,000 people as well as LGCM results stratified by age group and super- region, 1990–2019

From: Global pattern of trends in incidence, mortality, and mortality-to-incidence ratio rates related to liver cancer, 1990–2019: a longitudinal analysis based on the global burden of disease study

Super- region

Metric

Age group

Year

     

LGCM estimate

   

1990

1996

2002

2008

2014

2019

Intercept

Slope

 

Incidence

         
  

0–14

0.28(0.22,0.38)

0.28(0.22,0.39)

0.24(0.18,0.36)

0.22(0.14,0.36)

0.22(0.13,0.38)

0.23(0.13,0.41)

0.22*

−0.002*

  

15–49

0.57(0.54,0.60)

0.74(0.70,0.78)

0.78(0.76,0.81)

1.00(0.96,1.04)

1.07(1.02,1.12)

1.09(0.96,1.23)

0.89*

0.03*

  

50–69

8.55(8.31,8.81)

9.88(9.58,10.21)

9.51(9.29,9.72)

10.75(10.44,11.05)

11.19(10.87,11.55)

11.53(10.41,12.70)

20.80*

0.07*

  

> 70

18.78(17.82,19.39)

18.24(17.44,18.79)

18.05(17.28,18.46)

22.12(21.12,22.76)

23.73(22.48,24.52)

23.14(21.06,25.14)

32.38*

0.90*

CEEECA

Mortality

         
  

0–14

0.20(0.17,0.22)

0.19(0.17,0.21)

0.16(0.14,0.20)

0.15(0.11,0.21)

0.15(0.11,0.22)

0.14(0.09,0.22)

0.15*

−0.002*

  

15–49

0.51(0.49,0.54)

0.65(0.62,0.68)

0.68(0.65,0.71)

0.90(0.86,0.95)

0.93(0.88,0.98)

0.96(0.85,1.09)

0.82***

0.02*

  

50–69

8.35(8.12,8.60)

9.53(9.28,9.81)

9.12(8.89,9.38)

10.51(10.18,10.83)

10.62(10.31,10.98)

11.09(10.00,12.26)

20.53*

0.04*

  

> 70

22.28(21.10,23.01)

21.11(20.15,21.72)

20.72(19.78,21.30)

25.82(24.57,26.59)

27.28(25.70,28.23)

26.95(24.34,29.39)

38.21*

1.06*

 

1-MIR

         
  

0–14

0.27(0.21,0.41)

0.33(0.25,0.45)

0.35(0.24,0.44)

0.32(0.21,0.41)

0.33(0.18,0.42)

0.38(0.26,0.47)

0.30***

0.002*

  

15–49

0.11(0.11,0.11)

0.12(0.11,0.13)

0.13(0.13,0.12)

0.10(0.11,0.09)

0.13(0.13,0.13)

0.12(0.12,0.12)

0.10*

0.002*

  

50–69

0.02(0.02,0.02)

0.04(0.03,0.04)

0.04(0.04,0.04)

0.02(0.02,0.02)

0.05(0.05,0.05)

0.04(0.04,0.03)

0.02*

0.001*

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

 

Incidence

         
  

0–14

0.17(0.14,0.21)

0.18(0.15,0.22)

0.19(0.16,0.23)

0.20(0.17,0.25)

0.20(0.17,0.25)

0.20(0.16,0.26)

0.16***

0.001***

  

15–49

1.04(0.99,1.10)

1.31(1.28,1.35)

1.75(1.71,1.81)

1.78(1.72,1.84)

1.57(1.51,1.64)

1.57(1.39,1.77)

0.76***

0.02***

  

50–69

17.22(16.85,17.60)

21.66(21.17,22.14)

23.00(22.55,23.41)

21.82(21.30,22.27)

21.02(20.50,21.47)

20.94(18.92,23.31)

10.45***

0.09***

  

> 70

28.57(26.94,29.47)

39.76(36.83,41.28)

52.17(47.82,54.26)

57.20(51.25,60.24)

57.67(50.69,61.44)

57.38(49.26,63.45)

30.70***

0.63***

HI

Mortality

         
  

0–14

0.09(0.08,0.10)

0.08(0.08,0.10)

0.09(0.08,0.09)

0.08(0.08,0.09)

0.08(0.07,0.09)

0.08(0.07,0.09)

0.08***

0.01*

  

15–49

0.76(0.72,0.82)

0.91(0.89,0.95)

1.17(1.13,1.22)

1.05(1.01,1.10)

0.87(0.83,0.90)

0.86(0.79,0.94)

0.58***

0.01*

  

50–69

14.49(14.19,14.78)

17.65(17.28,17.99)

17.76(17.42,18.09)

15.80(15.41,16.14)

15.21(14.87,15.49)

15.18(14.29,15.86)

10.45***

0.09*

  

> 70

29.71(27.99,30.67)

39.15(36.28,40.59)

49.36(45.03,51.39)

52.13(46.38,54.94)

51.58(45.19,54.79)

51.22(44.59,54.84)

33.37***

0.46***

 

1-MIR

         
  

0–14

0.49(0.45,0.52)

0.53(0.49,0.57)

0.56(0.53,0.60)

0.58(0.56,0.62)

0.61(0.58,0.65)

0.61(0.57,0.66)

0.49***

0.004*

  

15–49

0.26(0.27,0.26)

0.30(0.31,0.30)

0.33(0.34,0.33)

0.41(0.41,0.41)

0.45(0.45,0.45)

0.45(0.43,0.47)

0.24***

0.01*

  

50–69

0.16(0.16,0.16)

0.19(0.18,0.19)

0.23(0.23,0.23)

0.28(0.28,0.28)

0.28(0.27,0.28)

0.28(0.24,0.32)

10.45***

0.09*

  

> 70

0.00(0.00,0.00)

0.02(0.01,0.02)

0.05(0.06,0.05)

0.09(0.09,0.09)

0.11(0.11,0.11)

0.11(0.09,0.14)

0.003***

0.001***

 

Incidence

         
  

0–14

0.16(0.13,0.20)

0.15(0.12,0.19)

0.15(0.12,0.19)

0.16(0.12,0.20)

0.15(0.12,0.20)

0.15(0.11,0.19)

0.13*

0.01**

  

15–49

0.57(0.55,0.60)

0.54(0.52,0.56)

0.46(0.44,0.48)

0.48(0.46,0.50)

0.50(0.47,0.52)

0.53(0.46,0.60)

0.53***

0.004**

  

50–69

8.96(8.58,9.34)

8.15(7.86,8.46)

6.78(6.50,7.05)

7.15(6.86,7.46)

7.70(7.40,8.01)

7.84(7.09,8.76)

8.72***

−0.03***

  

> 70

24.21(22.41,25.46)

21.64(20.04,22.70)

18.52(16.91,19.59)

20.40(18.62,21.49)

22.62(20.70,23.85)

22.78(20.19,25.18)

23.19***

0.28*

LAC

Mortality

         
  

0–14

0.14(0.12,0.16)

0.13(0.11,0.14)

0.12(0.11,0.14)

0.13(0.11,0.15)

0.12(0.10,0.14)

0.12(0.09,0.14)

0.11*

0.01**

  

15–49

0.50(0.48,0.52)

0.47(0.45,0.49)

0.40(0.39,0.42)

0.41(0.40,0.43)

0.43(0.41,0.45)

0.45(0.40,0.51)

0.47***

0.003**

  

50–69

8.76(8.38,9.15)

7.91(7.61,8.22)

6.64(6.35,6.93)

6.87(6.58,7.20)

7.45(7.17,7.75)

7.57(6.90,8.44)

6.97***

0.06***

  

> 70

28.75(26.60,30.26)

25.48(23.41,26.84)

22.23(20.26,23.54)

23.97(21.71,25.45)

26.99(24.65,28.42)

27.11(24.15,29.92)

20.116***

0.28*

 

1-MIR

         
  

0–14

0.12(0.07,0.19)

0.15(0.08,0.24)

0.17(0.11,0.27)

0.18(0.12,0.26)

0.19(0.15,0.28)

0.21(0.18,0.26)

0.21*

0.003**

  

15–49

0.12(0.12,0.12)

0.12(0.12,0.12)

0.12(0.12,0.12)

0.14(0.14,0.13)

0.14(0.14,0.14)

0.14(0.14,0.15)

0.11*

0.001**

  

50–69

0.02(0.02,0.02)

0.03(0.03,0.03)

0.02(0.02,0.02)

0.04(0.04,0.03)

0.03(0.03,0.03)

0.03(0.03,0.04)

0.02*

0.001*

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

 

Incidence

         
  

0–14

0.18(0.11,0.28)

0.16(0.11,0.23)

0.16(0.11,0.22)

0.16(0.11,0.21)

0.15(0.11,0.21)

0.14(0.10,0.20)

0.12***

−0.01**

  

15–49

1.02(0.86,1.23)

1.02(0.88,1.20)

1.01(0.90,1.14)

1.06(0.95,1.21)

1.16(1.00,1.36)

1.21(0.93,1.56)

0.80***

0.003**

  

50–69

18.79(16.18,21.53)

18.01(16.06,19.91)

17.78(16.35,19.13)

20.53(18.67,23.07)

20.73(17.88,24.49)

19.05(14.66,24.73)

14.92***

−0.02**

  

> 70

38.91(31.72,45.67)

36.74(32.14,40.97)

34.76(31.71,37.88)

37.16(34.30,39.94)

41.14(37.39,45.27)

41.38(34.93,49.23)

37.34***

0.27**

NAME

Mortality

         
  

0–14

0.19(0.13,0.29)

0.16(0.12,0.22)

0.15(0.12,0.20)

0.15(0.11,0.20)

0.14(0.11,0.18)

0.12(0.09,0.17)

0.12***

−0.001**

  

15–49

0.92(0.77,1.10)

0.91(0.77,1.08)

0.90(0.79,1.04)

0.91(0.80,1.04)

0.98(0.83,1.16)

1.00(0.75,1.31)

0.72***

0.001**

  

50–69

18.33(15.76,20.99)

17.61(15.62,19.62)

17.79(16.17,19.39)

19.02(17.33,21.05)

19.48(16.79,22.70)

17.73(13.56,23.21)

14.69***

−0.05**

  

> 70

45.40(37.11,53.20)

42.42(36.69,47.35)

41.37(37.45,45.03)

41.77(38.26,45.43)

45.60(41.27,49.93)

44.80(37.62,53.57)

45.17***

0.06**

 

1-MIR

         
  

0–14

0.00(0.00,0.00)

0.00(0.00,0.03)

0.02(0.00,0.08)

0.05(0.00,0.08)

0.09(0.01,0.13)

0.13(0.08,0.12)

0.08***

0.008**

  

15–49

0.11(0.11,0.10)

0.11(0.12,0.10)

0.11(0.12,0.09)

0.14(0.15,0.14)

0.16(0.17,0.15)

0.17(0.19,0.16)

0.11***

0.004**

  

50–69

0.02(0.03,0.03)

0.02(0.03,0.01)

0.00(0.01,0.00)

0.07(0.07,0.09)

0.06(0.06,0.07)

0.07(0.08,0.06)

0.02***

0.003**

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

SAa

Incidence

         
  

0–14

0.18(0.14,0.25)

0.19(0.15,0.26)

0.19(0.15,0.26)

0.19(0.15,0.27)

0.19(0.15,0.27)

0.20(0.15,0.30)

  

15–49

0.61(0.53,0.70)

0.64(0.56,0.71)

0.64(0.57,0.70)

0.65(0.58,0.72)

0.64(0.57,0.71)

0.65(0.56,0.76)

  

50–69

7.24(6.04,8.45)

7.48(6.28,8.48)

7.55(6.35,8.41)

7.57(6.46,8.43)

7.49(6.75,8.14)

7.25(6.14,8.48)

  

> 70

17.61(13.90,20.88)

18.21(14.50,21.36)

19.09(15.74,21.69)

18.63(15.64,20.88)

18.14(15.81,20.05)

18.17(15.63,20.82)

 

Mortality

         
  

0–14

0.20(0.16,0.24)

0.20(0.16,0.24)

0.18(0.15,0.22)

0.17(0.14,0.21)

0.17(0.14,0.21)

0.17(0.14,0.22)

  

15–49

0.54(0.47,0.62)

0.57(0.50,0.64)

0.57(0.50,0.63)

0.58(0.52,0.64)

0.56(0.51,0.62)

0.58(0.49,0.67)

  

50–69

7.08(5.88,8.16)

7.44(6.31,8.41)

7.43(6.21,8.35)

7.37(6.25,8.21)

7.05(6.34,7.74)

7.06(6.09,8.24)

  

> 70

20.64(16.27,24.41)

21.47(17.07,25.10)

22.75(18.96,25.70)

22.68(19.43,25.21)

21.40(19.08,23.59)

21.43(18.45,24.75)

 

1-MIR

         
  

0–14

0.00(0.00,0.02)

0.00(0.00,0.08)

0.03(0.00,0.15)

0.06(0.01,0.21)

0.08(0.03,0.22)

0.13(0.08,0.27)

  

15–49

0.11(0.11,0.12)

0.11(0.11,0.10)

0.12(0.13,0.10)

0.11(0.10,0.11)

0.12(0.11,0.13)

0.12(0.12,0.11)

  

50–69

0.02(0.03,0.03)

0.01(0.00,0.01)

0.02(0.02,0.01)

0.03(0.03,0.03)

0.06(0.06,0.05)

0.03(0.01,0.03)

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

 

Incidence

         
  

0–14

0.43(0.35,0.54)

0.46(0.39,0.54)

0.31(0.27,0.37)

0.21(0.18,0.27)

0.21(0.17,0.26)

0.20(0.16,0.25)

0.22***

−0.002*

  

15–49

7.95(6.75,9.37)

9.73(8.96,10.61)

6.64(6.23,7.13)

3.94(3.66,4.34)

4.39(3.98,4.87)

4.65(3.87,5.57)

2.74***

0.003**

  

50–69

64.55(54.53,77.31)

68.76(63.17,75.15)

47.12(44.09,50.66)

25.76(24.21,27.68)

25.66(23.59,28.04)

26.76(22.59,31.60)

29.44***

−0.22*

  

> 70

95.94(83.43,110.85)

106.62(98.76,114.94)

81.10(75.96,86.32)

51.83(48.48,55.38)

51.16(47.22,54.69)

53.07(46.30,59.79)

48.09***

−0.17*

SAEAO

Mortality

         
  

0–14

0.47(0.38,0.61)

0.49(0.43,0.57)

0.29(0.25,0.35)

0.20(0.18,0.24)

0.19(0.17,0.23)

0.18(0.15,0.22)

0.26***

−0.003***

  

15–49

7.16(6.03,8.45)

8.75(7.96,9.63)

5.31(4.86,5.87)

3.38(3.10,3.72)

3.49(3.07,3.94)

3.60(3.00,4.26)

2.41***

−0.002**

  

50–69

62.21(52.55,74.29)

66.15(59.95,72.75)

41.03(37.32,45.50)

24.39(22.42,26.42)

22.69(20.37,25.13)

23.43(19.94,27.09)

28.74***

−0.24*

  

> 70

111.15(97.85,127.62)

124.28(114.20,135.29)

85.31(78.54,92.30)

59.15(54.82,63.10)

55.57(51.05,59.80)

56.77(49.49,63.45)

56.50***

−0.22*

 

1-MIR

         
  

0–14

0.00(0.00,0.00)

0.00(0.00,0.00)

0.06(0.05,0.07)

0.04(0.01,0.10)

0.05(0.03,0.11)

0.09(0.09,0.11)

0.06*

0.003*

  

15–49

0.10(0.11,0.10)

0.10(0.11,0.09)

0.20(0.22,0.18)

0.14(0.15,0.14)

0.21(0.23,0.19)

0.23(0.23,0.23)

0.11*

0.001***

  

50–69

0.04(0.04,0.04)

0.04(0.05,0.03)

0.13(0.15,0.10)

0.05(0.07,0.05)

0.12(0.14,0.10)

0.12(0.12,0.14)

0.03*

0.001***

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

 

Incidence

         
  

0–14

0.29(0.19,0.42)

0.26(0.18,0.37)

0.22(0.15,0.30)

0.21(0.15,0.29)

0.21(0.14,0.30)

0.19(0.12,0.28)

0.27*

−0.004*

  

15–49

0.97(0.81,1.24)

1.06(0.93,1.21)

1.06(0.92,1.23)

0.94(0.82,1.07)

0.89(0.77,1.02)

0.89(0.74,1.05)

1.30***

−0.005*

  

50–69

12.30(10.32,15.48)

13.84(12.22,15.56)

13.75(12.22,15.53)

12.51(11.10,13.94)

11.88(10.58,13.31)

11.20(9.74,12.85)

17.89***

−0.03*

  

> 70

28.46(24.17,35.24)

32.75(29.50,36.24)

34.04(30.92,37.13)

31.85(29.36,34.63)

30.32(27.83,32.92)

28.83(26.17,31.56)

40.80***

−0.13*

SSA

Mortality

         
  

0–14

0.36(0.26,0.50)

0.32(0.24,0.43)

0.26(0.20,0.34)

0.25(0.19,0.32)

0.25(0.18,0.32)

0.22(0.15,0.31)

0.34***

−0.004*

  

15–49

0.85(0.71,1.10)

0.92(0.81,1.05)

0.92(0.80,1.07)

0.81(0.71,0.94)

0.79(0.68,0.91)

0.78(0.65,0.93)

1.08***

−0.006*

  

50–69

12.15(10.28,15.29)

13.84(12.30,15.51)

13.41(11.82,15.24)

12.21(10.78,13.62)

11.78(10.46,13.15)

11.02(9.57,12.58)

19.33***

−0.09*

  

> 70

33.65(28.59,41.74)

39.24(35.32,43.47)

40.43(36.38,44.42)

37.76(34.66,41.08)

36.13(33.18,39.20)

34.46(31.28,37.67)

47.06*

−0.09*

 

1-MIR

         
  

0–14

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

  

15–49

0.12(0.12,0.12)

0.13(0.13,0.13)

0.13(0.13,0.13)

0.13(0.14,0.12)

0.11(0.11,0.11)

0.11(0.12,0.12)

0.13*

−0.001**

  

50–69

0.01(0.00,0.01)

0.00(0.00,0.00)

0.02(0.03,0.02)

0.02(0.03,0.02)

0.01(0.01,0.01)

0.02(0.02,0.02)

0.01*

0.001**

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

 

Incidence

         
  

0–14

0.27(0.22,0.34)

0.27(0.23,0.33)

0.22(0.19,0.27)

0.19(0.16,0.24)

0.19(0.16,0.24)

0.19(0.15,0.24)

0.20***

−0.001*

  

15–49

3.25(2.83,3.74)

3.88(3.61,4.17)

2.86(2.71,3.02)

1.94(1.84,2.07)

1.99(1.85,2.13)

1.99(1.75,2.26)

1.30***

0.008*

  

50–69

28.35(25.27,32.11)

31.30(29.56,33.42)

25.14(24.08,26.32)

18.19(17.57,18.91)

17.99(17.17,18.87)

18.28(16.58,20.34)

18.12***

−0.04*

  

> 70

43.23(39.70,46.80)

50.97(48.08,53.60)

48.76(45.87,50.99)

42.76(39.62,44.60)

42.82(39.38,44.89)

43.19(38.68,46.98)

35.62***

−0.23*

Global

Mortality

         
  

0–14

0.28(0.23,0.35)

0.28(0.24,0.32)

0.20(0.18,0.24)

0.18(0.16,0.21)

0.18(0.15,0.20)

0.17(0.14,0.20)

0.20*

−0.002*

  

15–49

2.89(2.50,3.34)

3.44(3.16,3.74)

2.28(2.12,2.47)

1.60(1.51,1.73)

1.56(1.44,1.71)

1.54(1.35,1.74)

1.12*

0.004***

  

50–69

26.85(23.91,30.46)

29.41(27.36,31.56)

21.81(20.48,23.23)

16.18(15.49,16.88)

15.49(14.64,16.38)

15.77(14.33,17.25)

17.37***

−0.05***

  

> 70

48.98(44.98,52.91)

56.81(53.24,60.06)

50.43(47.01,52.83)

44.74(41.41,46.73)

43.64(39.92,45.93)

43.84(39.65,47.17)

41.62***

−0.18***

 

1-MIR

         
  

0–14

0.00(0.00,0.00)

0.00(0.00,0.02)

0.07(0.04,0.12)

0.07(0.02,0.15)

0.08(0.05,0.17)

0.12(0.10,0.18)

0.17*

0.003*

  

15–49

0.11(0.11,0.11)

0.11(0.12,0.10)

0.20(0.22,0.18)

0.17(0.18,0.17)

0.21(0.23,0.20)

0.23(0.22,0.23)

0.14*

0.002***

  

50–69

0.05(0.05,0.05)

0.06(0.07,0.06)

0.13(0.15,0.12)

0.11(0.12,0.11)

0.14(0.15,0.13)

0.14(0.14,0.15)

0.03*

0.001***

  

> 70

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

  1. Data in parentheses are 95% uncertainty intervals
  2. CEEECA Central Europe, Eastern Europe, and Central Asia, HI High Income, LAC Latin America and Caribbean, NAME North Africa and Middle East, SA South Asia, SAEAO Southeast Asia, East Asia, and Oceania, SSA Sub-Saharan Africa, MIR Mortality-to-incidence Ratio, LGCM Latent growth curve model
  3. * p<0.05, ** p>0.05, *** p<0.001
  4. aNot fitted LGCM, due to inadequate number of countries