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Table 3 Age specific incidence, mortality, and 1-MIR rates per 100,000 people as well as LGCM results stratified by age group and super- region, 1990–2019

From: Global pattern of trends in incidence, mortality, and mortality-to-incidence ratio rates related to liver cancer, 1990–2019: a longitudinal analysis based on the global burden of disease study

Super- region Metric Age group Year       LGCM estimate
    1990 1996 2002 2008 2014 2019 Intercept Slope
  Incidence          
   0–14 0.28(0.22,0.38) 0.28(0.22,0.39) 0.24(0.18,0.36) 0.22(0.14,0.36) 0.22(0.13,0.38) 0.23(0.13,0.41) 0.22* −0.002*
   15–49 0.57(0.54,0.60) 0.74(0.70,0.78) 0.78(0.76,0.81) 1.00(0.96,1.04) 1.07(1.02,1.12) 1.09(0.96,1.23) 0.89* 0.03*
   50–69 8.55(8.31,8.81) 9.88(9.58,10.21) 9.51(9.29,9.72) 10.75(10.44,11.05) 11.19(10.87,11.55) 11.53(10.41,12.70) 20.80* 0.07*
   > 70 18.78(17.82,19.39) 18.24(17.44,18.79) 18.05(17.28,18.46) 22.12(21.12,22.76) 23.73(22.48,24.52) 23.14(21.06,25.14) 32.38* 0.90*
CEEECA Mortality          
   0–14 0.20(0.17,0.22) 0.19(0.17,0.21) 0.16(0.14,0.20) 0.15(0.11,0.21) 0.15(0.11,0.22) 0.14(0.09,0.22) 0.15* −0.002*
   15–49 0.51(0.49,0.54) 0.65(0.62,0.68) 0.68(0.65,0.71) 0.90(0.86,0.95) 0.93(0.88,0.98) 0.96(0.85,1.09) 0.82*** 0.02*
   50–69 8.35(8.12,8.60) 9.53(9.28,9.81) 9.12(8.89,9.38) 10.51(10.18,10.83) 10.62(10.31,10.98) 11.09(10.00,12.26) 20.53* 0.04*
   > 70 22.28(21.10,23.01) 21.11(20.15,21.72) 20.72(19.78,21.30) 25.82(24.57,26.59) 27.28(25.70,28.23) 26.95(24.34,29.39) 38.21* 1.06*
  1-MIR          
   0–14 0.27(0.21,0.41) 0.33(0.25,0.45) 0.35(0.24,0.44) 0.32(0.21,0.41) 0.33(0.18,0.42) 0.38(0.26,0.47) 0.30*** 0.002*
   15–49 0.11(0.11,0.11) 0.12(0.11,0.13) 0.13(0.13,0.12) 0.10(0.11,0.09) 0.13(0.13,0.13) 0.12(0.12,0.12) 0.10* 0.002*
   50–69 0.02(0.02,0.02) 0.04(0.03,0.04) 0.04(0.04,0.04) 0.02(0.02,0.02) 0.05(0.05,0.05) 0.04(0.04,0.03) 0.02* 0.001*
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  Incidence          
   0–14 0.17(0.14,0.21) 0.18(0.15,0.22) 0.19(0.16,0.23) 0.20(0.17,0.25) 0.20(0.17,0.25) 0.20(0.16,0.26) 0.16*** 0.001***
   15–49 1.04(0.99,1.10) 1.31(1.28,1.35) 1.75(1.71,1.81) 1.78(1.72,1.84) 1.57(1.51,1.64) 1.57(1.39,1.77) 0.76*** 0.02***
   50–69 17.22(16.85,17.60) 21.66(21.17,22.14) 23.00(22.55,23.41) 21.82(21.30,22.27) 21.02(20.50,21.47) 20.94(18.92,23.31) 10.45*** 0.09***
   > 70 28.57(26.94,29.47) 39.76(36.83,41.28) 52.17(47.82,54.26) 57.20(51.25,60.24) 57.67(50.69,61.44) 57.38(49.26,63.45) 30.70*** 0.63***
HI Mortality          
   0–14 0.09(0.08,0.10) 0.08(0.08,0.10) 0.09(0.08,0.09) 0.08(0.08,0.09) 0.08(0.07,0.09) 0.08(0.07,0.09) 0.08*** 0.01*
   15–49 0.76(0.72,0.82) 0.91(0.89,0.95) 1.17(1.13,1.22) 1.05(1.01,1.10) 0.87(0.83,0.90) 0.86(0.79,0.94) 0.58*** 0.01*
   50–69 14.49(14.19,14.78) 17.65(17.28,17.99) 17.76(17.42,18.09) 15.80(15.41,16.14) 15.21(14.87,15.49) 15.18(14.29,15.86) 10.45*** 0.09*
   > 70 29.71(27.99,30.67) 39.15(36.28,40.59) 49.36(45.03,51.39) 52.13(46.38,54.94) 51.58(45.19,54.79) 51.22(44.59,54.84) 33.37*** 0.46***
  1-MIR          
   0–14 0.49(0.45,0.52) 0.53(0.49,0.57) 0.56(0.53,0.60) 0.58(0.56,0.62) 0.61(0.58,0.65) 0.61(0.57,0.66) 0.49*** 0.004*
   15–49 0.26(0.27,0.26) 0.30(0.31,0.30) 0.33(0.34,0.33) 0.41(0.41,0.41) 0.45(0.45,0.45) 0.45(0.43,0.47) 0.24*** 0.01*
   50–69 0.16(0.16,0.16) 0.19(0.18,0.19) 0.23(0.23,0.23) 0.28(0.28,0.28) 0.28(0.27,0.28) 0.28(0.24,0.32) 10.45*** 0.09*
   > 70 0.00(0.00,0.00) 0.02(0.01,0.02) 0.05(0.06,0.05) 0.09(0.09,0.09) 0.11(0.11,0.11) 0.11(0.09,0.14) 0.003*** 0.001***
  Incidence          
   0–14 0.16(0.13,0.20) 0.15(0.12,0.19) 0.15(0.12,0.19) 0.16(0.12,0.20) 0.15(0.12,0.20) 0.15(0.11,0.19) 0.13* 0.01**
   15–49 0.57(0.55,0.60) 0.54(0.52,0.56) 0.46(0.44,0.48) 0.48(0.46,0.50) 0.50(0.47,0.52) 0.53(0.46,0.60) 0.53*** 0.004**
   50–69 8.96(8.58,9.34) 8.15(7.86,8.46) 6.78(6.50,7.05) 7.15(6.86,7.46) 7.70(7.40,8.01) 7.84(7.09,8.76) 8.72*** −0.03***
   > 70 24.21(22.41,25.46) 21.64(20.04,22.70) 18.52(16.91,19.59) 20.40(18.62,21.49) 22.62(20.70,23.85) 22.78(20.19,25.18) 23.19*** 0.28*
LAC Mortality          
   0–14 0.14(0.12,0.16) 0.13(0.11,0.14) 0.12(0.11,0.14) 0.13(0.11,0.15) 0.12(0.10,0.14) 0.12(0.09,0.14) 0.11* 0.01**
   15–49 0.50(0.48,0.52) 0.47(0.45,0.49) 0.40(0.39,0.42) 0.41(0.40,0.43) 0.43(0.41,0.45) 0.45(0.40,0.51) 0.47*** 0.003**
   50–69 8.76(8.38,9.15) 7.91(7.61,8.22) 6.64(6.35,6.93) 6.87(6.58,7.20) 7.45(7.17,7.75) 7.57(6.90,8.44) 6.97*** 0.06***
   > 70 28.75(26.60,30.26) 25.48(23.41,26.84) 22.23(20.26,23.54) 23.97(21.71,25.45) 26.99(24.65,28.42) 27.11(24.15,29.92) 20.116*** 0.28*
  1-MIR          
   0–14 0.12(0.07,0.19) 0.15(0.08,0.24) 0.17(0.11,0.27) 0.18(0.12,0.26) 0.19(0.15,0.28) 0.21(0.18,0.26) 0.21* 0.003**
   15–49 0.12(0.12,0.12) 0.12(0.12,0.12) 0.12(0.12,0.12) 0.14(0.14,0.13) 0.14(0.14,0.14) 0.14(0.14,0.15) 0.11* 0.001**
   50–69 0.02(0.02,0.02) 0.03(0.03,0.03) 0.02(0.02,0.02) 0.04(0.04,0.03) 0.03(0.03,0.03) 0.03(0.03,0.04) 0.02* 0.001*
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  Incidence          
   0–14 0.18(0.11,0.28) 0.16(0.11,0.23) 0.16(0.11,0.22) 0.16(0.11,0.21) 0.15(0.11,0.21) 0.14(0.10,0.20) 0.12*** −0.01**
   15–49 1.02(0.86,1.23) 1.02(0.88,1.20) 1.01(0.90,1.14) 1.06(0.95,1.21) 1.16(1.00,1.36) 1.21(0.93,1.56) 0.80*** 0.003**
   50–69 18.79(16.18,21.53) 18.01(16.06,19.91) 17.78(16.35,19.13) 20.53(18.67,23.07) 20.73(17.88,24.49) 19.05(14.66,24.73) 14.92*** −0.02**
   > 70 38.91(31.72,45.67) 36.74(32.14,40.97) 34.76(31.71,37.88) 37.16(34.30,39.94) 41.14(37.39,45.27) 41.38(34.93,49.23) 37.34*** 0.27**
NAME Mortality          
   0–14 0.19(0.13,0.29) 0.16(0.12,0.22) 0.15(0.12,0.20) 0.15(0.11,0.20) 0.14(0.11,0.18) 0.12(0.09,0.17) 0.12*** −0.001**
   15–49 0.92(0.77,1.10) 0.91(0.77,1.08) 0.90(0.79,1.04) 0.91(0.80,1.04) 0.98(0.83,1.16) 1.00(0.75,1.31) 0.72*** 0.001**
   50–69 18.33(15.76,20.99) 17.61(15.62,19.62) 17.79(16.17,19.39) 19.02(17.33,21.05) 19.48(16.79,22.70) 17.73(13.56,23.21) 14.69*** −0.05**
   > 70 45.40(37.11,53.20) 42.42(36.69,47.35) 41.37(37.45,45.03) 41.77(38.26,45.43) 45.60(41.27,49.93) 44.80(37.62,53.57) 45.17*** 0.06**
  1-MIR          
   0–14 0.00(0.00,0.00) 0.00(0.00,0.03) 0.02(0.00,0.08) 0.05(0.00,0.08) 0.09(0.01,0.13) 0.13(0.08,0.12) 0.08*** 0.008**
   15–49 0.11(0.11,0.10) 0.11(0.12,0.10) 0.11(0.12,0.09) 0.14(0.15,0.14) 0.16(0.17,0.15) 0.17(0.19,0.16) 0.11*** 0.004**
   50–69 0.02(0.03,0.03) 0.02(0.03,0.01) 0.00(0.01,0.00) 0.07(0.07,0.09) 0.06(0.06,0.07) 0.07(0.08,0.06) 0.02*** 0.003**
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
SAa Incidence          
   0–14 0.18(0.14,0.25) 0.19(0.15,0.26) 0.19(0.15,0.26) 0.19(0.15,0.27) 0.19(0.15,0.27) 0.20(0.15,0.30)
   15–49 0.61(0.53,0.70) 0.64(0.56,0.71) 0.64(0.57,0.70) 0.65(0.58,0.72) 0.64(0.57,0.71) 0.65(0.56,0.76)
   50–69 7.24(6.04,8.45) 7.48(6.28,8.48) 7.55(6.35,8.41) 7.57(6.46,8.43) 7.49(6.75,8.14) 7.25(6.14,8.48)
   > 70 17.61(13.90,20.88) 18.21(14.50,21.36) 19.09(15.74,21.69) 18.63(15.64,20.88) 18.14(15.81,20.05) 18.17(15.63,20.82)
  Mortality          
   0–14 0.20(0.16,0.24) 0.20(0.16,0.24) 0.18(0.15,0.22) 0.17(0.14,0.21) 0.17(0.14,0.21) 0.17(0.14,0.22)
   15–49 0.54(0.47,0.62) 0.57(0.50,0.64) 0.57(0.50,0.63) 0.58(0.52,0.64) 0.56(0.51,0.62) 0.58(0.49,0.67)
   50–69 7.08(5.88,8.16) 7.44(6.31,8.41) 7.43(6.21,8.35) 7.37(6.25,8.21) 7.05(6.34,7.74) 7.06(6.09,8.24)
   > 70 20.64(16.27,24.41) 21.47(17.07,25.10) 22.75(18.96,25.70) 22.68(19.43,25.21) 21.40(19.08,23.59) 21.43(18.45,24.75)
  1-MIR          
   0–14 0.00(0.00,0.02) 0.00(0.00,0.08) 0.03(0.00,0.15) 0.06(0.01,0.21) 0.08(0.03,0.22) 0.13(0.08,0.27)
   15–49 0.11(0.11,0.12) 0.11(0.11,0.10) 0.12(0.13,0.10) 0.11(0.10,0.11) 0.12(0.11,0.13) 0.12(0.12,0.11)
   50–69 0.02(0.03,0.03) 0.01(0.00,0.01) 0.02(0.02,0.01) 0.03(0.03,0.03) 0.06(0.06,0.05) 0.03(0.01,0.03)
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  Incidence          
   0–14 0.43(0.35,0.54) 0.46(0.39,0.54) 0.31(0.27,0.37) 0.21(0.18,0.27) 0.21(0.17,0.26) 0.20(0.16,0.25) 0.22*** −0.002*
   15–49 7.95(6.75,9.37) 9.73(8.96,10.61) 6.64(6.23,7.13) 3.94(3.66,4.34) 4.39(3.98,4.87) 4.65(3.87,5.57) 2.74*** 0.003**
   50–69 64.55(54.53,77.31) 68.76(63.17,75.15) 47.12(44.09,50.66) 25.76(24.21,27.68) 25.66(23.59,28.04) 26.76(22.59,31.60) 29.44*** −0.22*
   > 70 95.94(83.43,110.85) 106.62(98.76,114.94) 81.10(75.96,86.32) 51.83(48.48,55.38) 51.16(47.22,54.69) 53.07(46.30,59.79) 48.09*** −0.17*
SAEAO Mortality          
   0–14 0.47(0.38,0.61) 0.49(0.43,0.57) 0.29(0.25,0.35) 0.20(0.18,0.24) 0.19(0.17,0.23) 0.18(0.15,0.22) 0.26*** −0.003***
   15–49 7.16(6.03,8.45) 8.75(7.96,9.63) 5.31(4.86,5.87) 3.38(3.10,3.72) 3.49(3.07,3.94) 3.60(3.00,4.26) 2.41*** −0.002**
   50–69 62.21(52.55,74.29) 66.15(59.95,72.75) 41.03(37.32,45.50) 24.39(22.42,26.42) 22.69(20.37,25.13) 23.43(19.94,27.09) 28.74*** −0.24*
   > 70 111.15(97.85,127.62) 124.28(114.20,135.29) 85.31(78.54,92.30) 59.15(54.82,63.10) 55.57(51.05,59.80) 56.77(49.49,63.45) 56.50*** −0.22*
  1-MIR          
   0–14 0.00(0.00,0.00) 0.00(0.00,0.00) 0.06(0.05,0.07) 0.04(0.01,0.10) 0.05(0.03,0.11) 0.09(0.09,0.11) 0.06* 0.003*
   15–49 0.10(0.11,0.10) 0.10(0.11,0.09) 0.20(0.22,0.18) 0.14(0.15,0.14) 0.21(0.23,0.19) 0.23(0.23,0.23) 0.11* 0.001***
   50–69 0.04(0.04,0.04) 0.04(0.05,0.03) 0.13(0.15,0.10) 0.05(0.07,0.05) 0.12(0.14,0.10) 0.12(0.12,0.14) 0.03* 0.001***
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  Incidence          
   0–14 0.29(0.19,0.42) 0.26(0.18,0.37) 0.22(0.15,0.30) 0.21(0.15,0.29) 0.21(0.14,0.30) 0.19(0.12,0.28) 0.27* −0.004*
   15–49 0.97(0.81,1.24) 1.06(0.93,1.21) 1.06(0.92,1.23) 0.94(0.82,1.07) 0.89(0.77,1.02) 0.89(0.74,1.05) 1.30*** −0.005*
   50–69 12.30(10.32,15.48) 13.84(12.22,15.56) 13.75(12.22,15.53) 12.51(11.10,13.94) 11.88(10.58,13.31) 11.20(9.74,12.85) 17.89*** −0.03*
   > 70 28.46(24.17,35.24) 32.75(29.50,36.24) 34.04(30.92,37.13) 31.85(29.36,34.63) 30.32(27.83,32.92) 28.83(26.17,31.56) 40.80*** −0.13*
SSA Mortality          
   0–14 0.36(0.26,0.50) 0.32(0.24,0.43) 0.26(0.20,0.34) 0.25(0.19,0.32) 0.25(0.18,0.32) 0.22(0.15,0.31) 0.34*** −0.004*
   15–49 0.85(0.71,1.10) 0.92(0.81,1.05) 0.92(0.80,1.07) 0.81(0.71,0.94) 0.79(0.68,0.91) 0.78(0.65,0.93) 1.08*** −0.006*
   50–69 12.15(10.28,15.29) 13.84(12.30,15.51) 13.41(11.82,15.24) 12.21(10.78,13.62) 11.78(10.46,13.15) 11.02(9.57,12.58) 19.33*** −0.09*
   > 70 33.65(28.59,41.74) 39.24(35.32,43.47) 40.43(36.38,44.42) 37.76(34.66,41.08) 36.13(33.18,39.20) 34.46(31.28,37.67) 47.06* −0.09*
  1-MIR          
   0–14 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
   15–49 0.12(0.12,0.12) 0.13(0.13,0.13) 0.13(0.13,0.13) 0.13(0.14,0.12) 0.11(0.11,0.11) 0.11(0.12,0.12) 0.13* −0.001**
   50–69 0.01(0.00,0.01) 0.00(0.00,0.00) 0.02(0.03,0.02) 0.02(0.03,0.02) 0.01(0.01,0.01) 0.02(0.02,0.02) 0.01* 0.001**
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  Incidence          
   0–14 0.27(0.22,0.34) 0.27(0.23,0.33) 0.22(0.19,0.27) 0.19(0.16,0.24) 0.19(0.16,0.24) 0.19(0.15,0.24) 0.20*** −0.001*
   15–49 3.25(2.83,3.74) 3.88(3.61,4.17) 2.86(2.71,3.02) 1.94(1.84,2.07) 1.99(1.85,2.13) 1.99(1.75,2.26) 1.30*** 0.008*
   50–69 28.35(25.27,32.11) 31.30(29.56,33.42) 25.14(24.08,26.32) 18.19(17.57,18.91) 17.99(17.17,18.87) 18.28(16.58,20.34) 18.12*** −0.04*
   > 70 43.23(39.70,46.80) 50.97(48.08,53.60) 48.76(45.87,50.99) 42.76(39.62,44.60) 42.82(39.38,44.89) 43.19(38.68,46.98) 35.62*** −0.23*
Global Mortality          
   0–14 0.28(0.23,0.35) 0.28(0.24,0.32) 0.20(0.18,0.24) 0.18(0.16,0.21) 0.18(0.15,0.20) 0.17(0.14,0.20) 0.20* −0.002*
   15–49 2.89(2.50,3.34) 3.44(3.16,3.74) 2.28(2.12,2.47) 1.60(1.51,1.73) 1.56(1.44,1.71) 1.54(1.35,1.74) 1.12* 0.004***
   50–69 26.85(23.91,30.46) 29.41(27.36,31.56) 21.81(20.48,23.23) 16.18(15.49,16.88) 15.49(14.64,16.38) 15.77(14.33,17.25) 17.37*** −0.05***
   > 70 48.98(44.98,52.91) 56.81(53.24,60.06) 50.43(47.01,52.83) 44.74(41.41,46.73) 43.64(39.92,45.93) 43.84(39.65,47.17) 41.62*** −0.18***
  1-MIR          
   0–14 0.00(0.00,0.00) 0.00(0.00,0.02) 0.07(0.04,0.12) 0.07(0.02,0.15) 0.08(0.05,0.17) 0.12(0.10,0.18) 0.17* 0.003*
   15–49 0.11(0.11,0.11) 0.11(0.12,0.10) 0.20(0.22,0.18) 0.17(0.18,0.17) 0.21(0.23,0.20) 0.23(0.22,0.23) 0.14* 0.002***
   50–69 0.05(0.05,0.05) 0.06(0.07,0.06) 0.13(0.15,0.12) 0.11(0.12,0.11) 0.14(0.15,0.13) 0.14(0.14,0.15) 0.03* 0.001***
   > 70 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00) 0.00(0.00,0.00)
  1. Data in parentheses are 95% uncertainty intervals
  2. CEEECA Central Europe, Eastern Europe, and Central Asia, HI High Income, LAC Latin America and Caribbean, NAME North Africa and Middle East, SA South Asia, SAEAO Southeast Asia, East Asia, and Oceania, SSA Sub-Saharan Africa, MIR Mortality-to-incidence Ratio, LGCM Latent growth curve model
  3. * p<0.05, ** p>0.05, *** p<0.001
  4. aNot fitted LGCM, due to inadequate number of countries