Socioeconomic differences in metabolic syndrome development: examining the mediating role of chronic stress using the Lifelines Cohort Study

Table 4 Multivariable mediation analysis of chronic stress^a in associations between socioeconomic position and metabolic syndrome development, using the Karlson-Holm-Breen method (n = 53,216)

	Education	Occupational prestige	Income
	OR (99% CI)	OR (99% CI)	OR (99% CI)
Total association	0.92 (0.90, 0.94)*	0.95 (0.91, 0.99)*	0.99 (0.98, 1.00)
Direct association	0.92 (0.90, 0.94)*	0.95 (0.91, 0.99)*	1.00 (0.99, 1.00)
Indirect association	1.00 (1.00, 1.01)*	1.00 (1.00, 1.00)*	1.00 (1.00, 1.00)
	Percentage	Percentage	Percentage
Mediating effect
Sum score	−5.6	−6.2	25.1
Mediating effects per highlighted domain of life
Work-related	−0.5	−1.0	−1.1
Relationship-related (with partner)	2.7	2.9	−12.2
Finance-related	−2.3	0.4	51.5

OR Odds ratio, CI Confidence interval, SEP Socioeconomic position, MetS Metabolic syndrome, LDI Long-term Difficulties Inventory; analyses controlled for years of education, equivalized household income, occupational prestige, age and sex at T1, and time between T1 and T4; reference category for the LDI domains was ‘not stressful’; LDI domains were controlled for work status, partner status, children status, parent status, school/study status and religion status where applicable
*P < 0.01
^aLong-term difficulties during total follow-up time measured with the LDI

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