Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up

Table 4 Hazard ratios (HRs) and 95% confidence intervals (CI) for transition from MHO to MUO phenotype based on tertiles of wrist circumference in females

	Unadjusted		Age-adjusted		Model 1		Model 2
	HR (%95 CI)	P -value	HR (%95 CI)	P -value	HR (%95 CI)	P -value	HR (%95 CI)	P -value
Wrist circumference
Tertile 1 (<15.5 cm)	1 (reference)		1 (reference)		1 (reference)		1 (reference)
Tertile 2 (15.5-16.1 cm)	1.34 (1.09-1.66)	0.005	1.35 (1.10-1.67)	0.004	1.33 (1.09-1.70)	0.007	1.32 (1.05-1.65)	0.012
Tertile 3 (>16.1 cm)	1.61 (1.30-2.00)	<0.001	1.50 (1.21-1.85)	<0.001	1.46 (1.16-1.84)	0.001	1.34 (1.06-1.96)	0.016
P for trend	<0.001		0.001		0.003		0.025
Age			1.43 (1.31-1.56)	<0.001	1.43 (1.30-1.57)	<0.001	1.38 (1.25-1.52)	<0.001
Smoking					1.17 (0.73-1.86)	0.512	1.21 (0.76-1.93)	0.420
Education level (below diploma)					0.93 (0.72-1.20)	0.575	0.91 (0.70-1.17)	0.456
Low physical activity					0.96 (0.81-1.14)	0.632	0.95 (0.70-1.13)	0.567
SBP					1.04 (0.94-1.05)	0.412	1.06 (0.96-1.17)	0.229
DBP					1.12 (1.01-1.24)	0.038	1.11 (0.99-1.23)	0.056
FPG					1.17 (1.04-1.30)	0.007	1.14 (1.02-1.28)	0.023
2-h PG					1.13 (0.92-1.10)	0.790	1.02 (0.93-1.11)	0.735
Triglycerides					1.20 (1.11-1.29)	<0.001	1.18 (1.10-1.27)	<0.001
HDL					0.79 (0.72-0.87)	<0.001	0.77 (0.70-0.84)	<0.001
Body mass index							1.02 (0.91-1.15)	0.691
Waist circumference							1.17 (1.05-1.31)	0.005
Hip circumference							0.98 (0.87-1.10)	0.715

Hazard ratios for the continuous variables are reported per 1 standard deviation
SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, 2-h PG 2-h post-challenge plasma glucose, HDL high-density lipoprotein, LDL low-density lipoprotein

ISSN: 1471-2458