Table 3 Primary and secondary outcome measures and endpoints for the SYCT substudy

 Self-reported data on social distancing, quarantine, social connectedness, healthcare utilization, well-being

The proportion of respondents who report adhering to social distancing guidelines after a test result for the entire study cohort and stratified by participant demographics (e.g., gender) of interest; comparison of proportion adherent after positive vs. negative test result

 Self-reported data on awareness of the issue, engagement, decisions to act, action, and maintenance

The proportion of respondents who decide to act on precautionary behaviors after a test result for the entire study cohort and stratified by participant demographics (e.g., gender) of interest

 Self-reported emergency department visits, hospitalizations, and intensive care unit admission, for SARS CoV-2 evaluation or treatment

Point estimate and 95% confidence interval for each healthcare utilization measure and composite measure for the entire study cohort and stratified by participant demographics (e.g., gender) of interest

 Self-reported data on perceptions and prevention of risks of contracting SARS CoV-2 infection

The proportion of respondents who are knowledgeable of precautionary measures to prevent infection for the entire study cohort and stratified by participant demographics (e.g., gender) of interest

 Reported results of self-administered SARS CoV-2 antigen test

Prevalence of positive test results with 95% confidence intervals for the entire study cohort and stratified by participant demographic variables of interest

 Self-reported data on acceptability, practicality, integration, penetration, and demand of at-home self-administered antigen test

The proportion of respondents who find at-home self-administered antigen test acceptable for the entire study cohort and stratified by participant demographics (e.g., gender) of interest

 Mobility patterns as captured by surrogates, including activity trackers

Distribution of individual mobility data in response to positive vs. negative SARS CoV-2 test results

 Self-reported data on perceived susceptibility, severity, benefits, barriers, and cues to action related to SARS CoV-2 vaccination

Distribution of respondent’s perception about SARS CoV-2 vaccination for the entire study cohort and stratified by participant demographics (e.g., gender) of interest