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Table 2 Predictors of readmission

From: Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data

Predictor

Readmitted (N = 682, col % or median (IQR))

Not readmitted (N = 3212, col % or median (IQR))

Univariate SHR (95% CI)

Multivariate SHR (95% CI)

p value

Sitea - Mbale

278 (41%)

1203 (37%)

1.00

1.00

0.25

 Blantyre

53 (8%)

402 (13%)

0.61 (0.45–0.82)

0.80 (0.57–1.12)

 

 Mulago

136 (20%)

776 (24%)

0.79 (0.65–0.97)

0.82 (0.65–1.03)

 

 Soroti

215 (32%)

831 (26%)

1.08 (0.90–1.29)

0.97 (0.79–1.19)

 

Age at primary admission (per year younger)a

38.0 (17.0, 60.0)

34.0 (17.0, 62.0)

1.01 (0.98–1.03)

1.07 (1.03–1.10)

< 0.001

HIV positivea

26 (4%)

81 (3%)

1.52 (1.02–2.28)

2.48 (1.63–3.78)

< 0.001

Sickle status - AA

458 (67%)

2243 (70%)

1.00

1.00

0.01

 AS

25 (4%)

99 (3%)

1.23 (0.82–1.84)

1.16 (0.75–1.81)

 

 SS, unknown at discharge

122 (18%)

486 (15%)

1.15 (0.94–1.39)

0.95 (0.76–1.20)

 

 SS, known at discharge

73 (11%)

353 (11%)

0.98 (0.77–1.25)

0.62 (0.46–0.82)

 

Two or more hospital admissions in the last year before primary admissiona

250 (37%)

651 (20%)

2.05 (1.76–2.40)

1.44 (1.19–1.74)

< 0.001

Received blood transfusion ever, prior to this illnessa

341 (50%)

939 (29%)

2.17 (1.87–2.52)

1.48 (1.13–1.93)

0.005

History of cough at primary admissiona

459 (67%)

1973 (61%)

1.27 (1.08–1.49)

1.13 (0.95–1.35)

0.16

Indrawing on admissiona

118 (17%)

378 (12%)

1.51 (1.24–1.84)

1.36 (1.09–1.71)

0.01

Splenomegaly on admissiona - Not palpable

363 (53%)

2132 (66%)

1.00

1.00

0.01

 Enlarged

248 (36%)

884 (28%)

1.57 (1.33–1.84)

1.26 (1.06–1.50)

 

 Gross

71 (10%)

190 (6%)

2.02 (1.57–2.61)

1.47 (1.10–1.97)

 

Diarrhoea on admission

68 (10%)

437 (14%)

0.72 (0.56–0.92)

0.71 (0.54–0.93)

0.01

Received oral antimalarials in last week before primary admission

359 (53%)

1529 (48%)

1.21 (1.04–1.41)

1.08 (0.92–1.27)

0.36

Malaria positive at primary admission, no previous blood transfusion

195 (29%)

1533 (48%)

0.65 (0.52–0.81)

0.60 (0.47–0.76)

< 0.001

Malaria positive at primary admission, previous blood transfusion

209 (31%)

539 (17%)

1.73 (1.40–2.14)

1.58 (1.22–2.04)

< 0.001

Randomised > 24 h after admissiona

37 (5%)

131 (4%)

1.28 (0.92–1.77)

1.36 (0.96–1.93)

0.08

Strataa - TRACT A

452 (66%)

1884 (59%)

1.00

1.00

0.14

TRACT B, immediate transfusion

122 (18%)

655 (20%)

0.78 (0.64–0.95)

0.93 (0.74–1.17)

 

TRACT B, triggered transfusion

69 (10%)

312 (10%)

0.91 (0.71–1.17)

1.05 (0.79–1.40)

 

TRACT B, no transfusion

39 (6%)

361 (11%)

0.48 (0.35–0.67)

0.67 (0.47–0.96)

 

Blood pack age (per week older)a

12.0 (7.0, 20.0)

12.0 (7.0, 17.0)

1.10 (1.03–1.18)

1.07 (0.99–1.15)

0.08

Length of stay (per day longer)a

3.0 (2.0, 5.0)

3.0 (2.0, 4.0)

1.05 (1.03–1.07)

1.03 (1.00–1.06)

0.04

Missed dose of MVMM, iron folate or cotrimoxazole by 28 days

245 (36%)

925 (29%)

1.35 (1.15–1.58)

1.43 (1.21–1.69)

< 0.001

  1. aselected by initial backwards elimination: retained in final model regardless of significance for control of confounding
  2. Note: Denominators based on children with observed data; numbers missing are given in Supplementary Table 1. Site and receipt of transfusion were included in all models. Final model included 3384/3894 (87%) children discharged alive and 609/682 (89%) readmitted children (exclusions due to missing data). All continuous factors were selected as linear. SHR = sub-hazard ratio from competing risks model (treating death before readmission as a competing risk). TRACT A = severe complicated anaemia (randomised to 30 vs 20 mls/kg transfusion). TRACT B = severe uncomplicated anaemia (randomised to immediate transfusion vs triggered transfusion; those who ultimately received a transfusion are labelled “triggered transfusion” and those who did not “no transfusion”)