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Table 7 ⍺- and β-globin genotypes identified in Thai and migrant cohorts in Chonburi, Thailand

From: Feasibility of and barriers to thalassemia screening in migrant populations: a cross-sectional study of Myanmar and Cambodian migrants in Thailand

Disease Category Genotype   Migrants
Thai (N = 1232) Myanmar (N = 121) Cambodian (N = 156) Combined (N = 277)
N % N % N % N %
Carriers of ⍺-globin variant -⍺3.7/⍺⍺ 126 10.2 34 28.1 30 19.2 64 23.1
-⍺4.2/⍺⍺ 13 1.1 1 0.8 0 0 1 0.4
-⍺3.7/−⍺3.7 4 0.3 2 1.7 1 0.6 3 1.1
-⍺3.7/−⍺4.2 1 0.1 0 0 1 0.6 1 0.4
-⍺3.7/⍺CS⍺ 8 0.6 0 0 0 0 0 0
- -SEA/⍺⍺ 34 2.8 1 0.8 2 1.3 3 1.1
⍺CS⍺/⍺⍺ 35 2.8 0 0 0 0 0 0
⍺PS⍺/⍺⍺ 1 0.1 0 0 0 0 0 0
⍺QZ⍺/⍺⍺ 1 0.1 0 0 0 0 0 0
Total 223 18.1 38 31.4 34 21.8 72 26.0
Carriers of β-globin variant βE/β 186 15.1 10 8.3 29 18.6 39 14.1
βD/β 3 0.2 0 0 0 0 0 0
βIVSI-1/β 1 0.1 1 0.8 1 0.6 2 0.7
βIVSII-654/β 1 0.1 0 0 0 0 0 0
βCD17/β 5 0.4 0 0 0 0 0 0
βCD71/72/β 1 0.1 1 0.8 0 0 1 0.4
βCD41/42/β 1 0.1 0 0 0 0 0 0
βCD27/28/β 1 0.1 0 0 0 0 0 0
β−28/β 1 0.1 0 0 0 0 0 0
β-3.48/β 2 0.2 1 0.8 0 0 1 0.4
Total 202 16.4 13 10.7 30 19.2 43 15.5
Double heterozygous carriers -⍺3.7/⍺⍺ + βE/β 28 2.3 2 1.7 18 11.5 20 7.2
-⍺4.2/⍺⍺ + βE/β 6 0.5 0 0 0 0 0 0
-⍺3.7/−⍺3.7 + βE/β 5 0.4 0 0 2 1.3 2 0.7
- -SEA/⍺⍺ + βE/β 8 0.6 0 0 1 0.6 1 0.4
- -THAI/⍺⍺ + βE/β 0 0 0 0 1 0.6 1 0.4
⍺CS⍺/⍺⍺ + βE/β 5 0.4 0 0 0 0 0 0
⍺PS⍺/⍺⍺ + βE/β 0 0 0 0 1 0.6 1 0.4
-⍺3.7/⍺⍺ + βD/β 1 0.1 0 0 0 0 0 0
-⍺3.7/⍺⍺ + βCD41/42/β 1 0.1 0 0 0 0 0 0
-⍺3.7/⍺⍺ + βCD35/β 1 0.1 0 0 0 0 0 0
-⍺3.7/⍺⍺ + β−28/β 1 0.1 0 0 0 0 0 0
-⍺3.7/⍺⍺ + βIVSI-1/β 0 0 2 0.8 0 0 2 0.7
-⍺3.7/⍺⍺ + βCD110/β a 0 0 1 0.8 0 0 1 0.4
⍺CS⍺/⍺⍺ + βIVSI-1/β 1 0.1 0 0 0 0 0 0
Total 57 4.6 5 4.1 23 14.7 28 10.1
Homozygous Hb E (with/without ⍺-thalassemia) βE/βE 25 2.0 0 0 3 0.2 3 1.1
-⍺3.7/⍺⍺ + βE/βE 4 0.3 1 0.1 1 0.1 2 0.7
-⍺3.7/−⍺3.7 + βE/βE 1 0.1 0 0 0 0 0 0
⍺CS⍺/⍺⍺ + βE/βE 3 0.2 0 0 0 0 0 0
Total 33 2.7 1 0.8 4 2.6 5 1.8
Hb H disease (with/without ⍺-thalassemia) - -SEA/−⍺3.7 6 0.5 0 0 0 0 0 0
- -SEA/⍺CS⍺ 3 0.2 0 0 0 0 0 0
- -SEA/⍺CS⍺ + βE/β 1 0.1 0 0 0 0 0 0
- -SEA/⍺WM⍺ + βE/β 1 0.1 0 0 0 0 0 0
Total 11 0.9 0 0 0 0 0 0
Compound heterozygous β-thalassemia βCD41/42/βE 1 0.1 0 0 0 0 0 0
Total 1 0.1 0 0 0 0 0 0
Other ⍺-thalassemia diseases ⍺CS⍺/⍺CS⍺ 1 0.1 0 0 0 0 0 0
⍺CS⍺/⍺PS⍺ + βE/β 1 0.1 0 0 0 0 0 0
⍺ triplication 5 0.4 NT NT NT NT NT NT
⍺ triplication + βE/β 6 0.5 NT NT NT NT NT NT
Total 13 1.1 0 0 0 0 0 0
Any thalassemia carrier Total 540 43.8 57 47.1 91 58.3 148 53.4
  1. NT Not tested, CS Constant Spring, PS Pakse, QZ Quang Sze, WM Westmead
  2. a βCD110 is also known as Hb Showa-Yakushiji
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