Table 3 Optimal combination of Wolbachia and paediatric dengue vaccination coverage to minimize the number of dengue cases (and DALYs lost) by budget constraint
Budget constraint ($ millions) | Wolbachia (%) | Paediatric vaccination (%) | Cases (millions) | DALYs lost | Wolbachia costs ($ millions) | Vaccination costs ($ millions) | Total costs (PP) ($ millions) |
|---|---|---|---|---|---|---|---|
Steady state | 0 | 0 | 7.175 | 67,831 | – | – | $337.830a |
≥ 590 | 100 | 100 | 1.022 | 9660 | 273.744 | 350.666 | $678.674 |
≤ 589 | 67 | 100 | 1.046 | 9888 | 182.496 | 350.666 | $588.677 |
≤ 368 | 50 | 49 | 1.194 | 11,288 | 135.489 | 170.020 | $368.772 |
≤ 251 | 54 | 10 | 1.296 | 12,256 | 147.854 | 25.331 | $251.601 |