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Table 4 Odds ratio and 95% confidence interval (CI) for multimorbidity at age 55 by different life course models

From: Multimorbidity and leisure-time physical activity over the life course: a population-based birth cohort study

 

Model 1

Model 2

Model 3

OR

95% CI

p value

OR

95% CI

p value

OR

95% CI

p value

Saturation model

 0,0,0,0,0

1.01

0.32, 1.01

0.054

1.68

0.45, 1.68

0.678

1.99

0.45, 1.99

0.896

 0,0,0,1,0

2.29

0.67, 2.29

0.504

3.81

0.93, 3.81

0.081

5.25

1.10, 5.25

0.027

 0,0,1,0,0

0.95

0.32, 0.95

0.031

1.31

0.37, 1.31

0.266

1.37

0.33, 1.37

0.272

 0,0,1,0,1

1.51

0.53, 1.51

0.682

2.38

0.7, 2.38

0.416

2.04

0.50, 2.04

0.975

 0,0,1,1,0

0.80

0.29, 0.8

0.005

1.31

0.4, 1.31

0.284

1.70

0.45, 1.70

0.698

 0,0,1,1,1

1.44

0.51, 1.44

0.553

2.49

0.74, 2.49

0.323

3.14

0.80, 3.14

0.184

 0,1,1,0,0

0.79

0.35, 0.79

0.002

1.33

0.51, 1.33

0.420

1.71

0.58, 1.71

0.981

 0,1,1,0,1

1.84

0.47, 1.84

0.835

2.75

0.52, 2.75

0.676

3.03

0.48, 3.03

0.698

 0,1,1,1,1

1.06

0.24, 1.06

0.070

1.84

0.33, 1.84

0.574

2.21

0.33, 2.21

0.739

 1,0,0,0,0

2.11

0.24, 2.11

0.546

3.02

0.1, 3.02

0.499

2.40

0.07, 2.40

0.312

 1,0,0,0,1

0.85

0.2, 0.85

0.017

1.82

0.37, 1.82

0.622

2.87

0.49, 2.87

0.703

 1,0,0,1,0

1.59

0.47, 1.59

0.645

2.34

0.58, 2.34

0.664

2.40

0.49, 2.40

0.841

 1,0,0,1,1

0.83

0.27, 0.83

0.009

1.39

0.38, 1.39

0.333

1.74

0.40, 1.74

0.631

 1,0,1,0,0

0.88

0.28, 0.88

0.016

1.28

0.33, 1.28

0.210

1.59

0.34, 1.59

0.440

 1,0,1,0,1

0.66

0.28, 0.66

< 0.001

1.05

0.39, 1.05

0.074

1.45

0.47, 1.45

0.516

 1,0,1,1,0

1.83

0.57, 1.83

0.933

2.94

0.75, 2.94

0.260

2.60

0.55, 2.60

0.648

 1,0,1,1,1

1.47

0.39, 1.47

0.419

2.34

0.51, 2.34

0.825

3.59

0.66, 3.59

0.321

 1,1,0,0,0

1.82

0.37, 1.82

0.622

3.61

0.58, 3.61

0.421

4.84

0.61, 4.84

0.307

 1,1,0,0,1

1.45

0.46, 1.45

0.496

2.20

0.59, 2.2

0.695

3.05

0.71, 3.05

0.304

 1,1,0,1,0

1.33

0.45, 1.33

0.351

1.99

0.55, 1.99

0.882

2.50

0.6, 2.5

0.580

 1,1,0,1,1

0.95

0.32, 0.95

0.032

1.29

0.36, 1.29

0.245

1.82

0.44, 1.82

0.760

 1,1,1,0,0

1.00

0.33, 1

0.049

1.58

0.44, 1.58

0.587

2.06

0.49, 2.06

0.987

 1,1,1,0,1

0.90

0.39, 0.9

0.013

1.34

0.51, 1.34

0.438

1.92

0.64, 1.92

0.713

 1,1,1,1,0

2.29

0.57, 2.29

0.703

2.69

0.56, 2.69

0.608

3.25

0.56, 3.25

0.507

Critical period

 Childhood

1.01

0.91; 1.12

0.877

0.96

0.85; 1.09

0.526

0.97

0.84; 1.13

0.744

 Adolescence

0.90

0.81; 1.00

0.052

0.88

0.77; 1.01

0.081

0.82

0.70; 0.97

0.023

 Young-adult

0.74

0.66; 0.84

< 0.001

0.82

0.71; 0.95

0.008

0.94

0.79; 1.12

0.497

 Middle-aged adults

0.77

0.69; 0.85

< 0.001

0.85

0.76; 0.96

0.009

0.90

0.77; 1.03

0.137

 Middle-to-older adults

0.64

0.57; 0.70

< 0.001

0.69

0.61; 0.78

< 0.001

0.85

0.73; 0.98

0.027

Accumulation

 Categorical

  None

Ref

  

Ref

  

Ref

  

  One

0.48

0.21; 1.07

0.072

0.56

0.22; 1.39

0.210

0.69

0.23; 2.08

0.513

  Two

0.45

0.21; 0.97

0.041

0.56

0.23; 1.32

0.183

0.69

0.24; 1.96

0.483

  Three

0.38

0.17; 0.81

0.012

0.47

0.20; 1.11

0.177

0.65

0.23; 1.84

0.420

  Four

0.32

0.15; 0.67

< 0.001

0.39

0.17; 0.91

0.030

0.57

0.21; 1.61

0.291

  Five

0.29

0.14; 0.63

< 0.001

0.33

0.14; 0.78

0.011

0.52

0.18; 1.46

0.213

 Continuous

0.86

0.81; 0.91

< 0.001

0.85

0.79; 0.91

< 0.001

0.91

0.84; 0.99

0.001

Sensitive period

 Childhood

1.00

0.91; 1.12

0.877

0.96

0.81; 1.15

0.683

0.98

0.80; 1.20

0.848

 Adolescence

0.90

0.81; 1.00

0.052

0.81

0.67; 0.99

0.041

0.83

0.70, 0.98

0.025

 Young-adult

0.74

0.66; 0.84

< 0.001

0.87

0.70; 1.07

0.187

0.98

0.77; 1.25

0.265

 Middle-aged adults

0.77

0.69; 0.84

< 0.001

0.91

0.75; 1.09

0.305

0.90

0.72; 1.12

0.338

 Middle-to-older adults

0.63

0.57; 0.70

< 0.001

0.69

0.59; 0.79

< 0.001

0.82

0.69; 0.98

0.025

  1. Numbers in bold indicates statistical significance (p < 0.05)
  2. Each number position (“0” for inactive or “1” for active) for the saturation model represents, respectively, 5 lifetime stages: childhood, adolescence, and young, middle, and middle-to-older adults
  3. Model 1: Unadjusted
  4. Model 2: Adjusted for sex, education, income, marital status, country of birth, ethnicity
  5. Model 3: Model 2 + smoking, alcohol, and hours of sleep at age 50