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Table 5 Tuberculosis risk/odds by silica exposure, dustiness of occupation or exposure duration, controlling for silicosis

From: The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis

Sherson 1990 [47] Hnizdo 1998 [49] Corbett 1999 [50] Corbett 2000 [51] Yarahmadi 2013 [54]
SIR or RR a (95% CI) RR (95% CI) OR 95%CI) RR (95%CI) OR (95% CI)
Silicotics excluded. White miners, >  10 years’ exposure; adjusted for silicosis b, age, smoking. Adjusted for silicosis, age, HIV. Adjusted for silicosis, age, HIV. Silicotics excluded. No other adjustment.
Binary or summary effect measures
 Duration of employment (yr), (RR)
< 15: 1.00
>  15: 2.39 (0.96, 6.44)
Per 8 mg-yr/m3 c
1.95 (1.58, 2.2)
Occupation (dusty job at diagnosis)
No: 1.00
Yes 1.00 (0.62, 1.63)
Occupation (underground vs surface)
No: 1.00
Yes: 2.00 (1.11, 3.33)
Silica exposure
None: 1.00
Any: 2.85 (1.13, 3.42)
Dose-response
 Duration of employment (yr), SIR
General male population: 100
0.15–14.5: 133 (57, 262)
15.0–24.5: 128 (26, 375)
> 25: 353 (130, 768)
Cumulative dust (mg-yr/m3) quartile
1: 1.00
2: 1.51 (0.78, 2.91)
3: 2.35 (1.28, 4.32)
4: 3.22 (1.75, 5.90)
Duration of employment (yr)
<  10: 1.00
10–14: 1.9 (1.07, 3.36)
15–19: 4.4 (2.45, 7.75)
> 20: 3.6 (1.84, 7.12)
Duration of exposure (yr)
0–4: 1.8 (0.9, 3.5)
5–9: 1.00
10–19: 1.6 (1.0, 2.5)
>  20: 1.3 (0.8, 2.3)
 
Duration of employment (yr), (RR)
0.05–14.5: 1.00
15–24.5: 1.44 (0.38, 5.43)
>  25: 3.9 (1.36, 11.23)a
    
  1. RR relative risk or rate ratio (see Table 1), SIR standardised incidence ratio, CI confidence interval, RR odds ratio
  2. a RR estimated for this review comparing silicotics with non-silicotics in the same cohort
  3. b Adjustment for radiological silicosis. Analysis by adjustment for radiological or autopsy silicosis yielded similar findings
  4. c RR for 1 mg-yr/m3 = 1.10 (1.06, 1.13). RR scaled to interquartile range (see Table 1 of the publication) of 10–17.99 mg-yr/m3 (as used in [58])