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Table 3 Risk or odds of tuberculosis by severity of silicosis

From: The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis

Study by date
of publication
(effect measure)
Cowie 1994
(IR) [48]
Hnizdo 1998
(RR) [49]
(Autopsy grading)
Corbett 1999
(OR) [50]
Corbett 2000
(RR) [51]
Chang 2001
(RR) [52]
Adjusted/controlled for.
N
Age, date of CXR.
N = 1153
Age, smoking.
N = 2255
Age, HIV, duration employed, dusty job. N = 561 Age, HIV, duration employed, underground/surface job.
N = 4022
Age, sex, smoking.
N = 707
Grades or markers of extent of silicosis None (n = 335):
1.0 (0, 2.0)
ILO 1 (n = 418):
2.2 (0.7, 3.6)
ILO 2 (n = 355):
2.9 (1.1, 4.6)
ILO 3 (n = 45):
6.3 (0, 13.4)
None (n = 577): 1.00
Negligible (n = 310):
1.86 (0.97, 3.58)
Slight (n = 196):
2.62 (1.36, 5.03)
Moderate/ marked(n = 213):
2.71 (1.41, 5.20)
None (n = 340):
1.00
ILO 0/1 (n = 69):
1.6 (0.86, 2.90)
ILO 1/0 (n = 48):
2.8 (1.24, 6.46)
ILO > 1/1 (n = 90):
4.9 (2.32, 10.58)
None (n = 2924): 1.00
ILO 0/1 (n = 460):
1.4 (1.0, 2.2)
ILO 1/0 (n = 212):
1.8 (1.0, 3.0)
ILO 1/1 (n = 156):
2.2 (1.3, 3.7)
ILO > 1/1 (n = 197):
2.5 (1.6, 4.0)
PMF (n = 141) vs no
PMF (n = 566): 3.78
(2.24, 6.35)
  1. 95% confidence intervals in parentheses. IR incidence rate (annual), RR relative risk, rate ratio or risk ratio (see Table 1), OR odds ratio;
  2. CXR chest x-ray, ILO International Labour Organization, PMF progressive massive fibrosis