| No. of Observations | No. of Cases | Person years of follow-up | Incidence density (1/1000 person-years) | Model 1 Hazard ratio (95%CI) | P value | Model 2 Hazard ratio (95%CI) | P value |
---|---|---|---|---|---|---|---|---|
Age (years) | ||||||||
 < 50 | 5038 | 181 | 53,207 | 3.40 |  |  |  |  |
  Q1 | 464 | 30 | 4976 | 6.03 | 1.00 |  | 1.00 |  |
  Q2 | 1005 | 34 | 10,574 | 3.22 | 0.53 (0.33–0.87) | 0.012* | 0.58 (0.35–0.97) | 0.037* |
  Q3 | 1580 | 46 | 16,701 | 2.75 | 0.46 (0.29–0.72) | < 0.001* | 0.51 (0.31–0.82) | 0.006* |
  Q4 | 1989 | 71 | 20,956 | 3.39 | 0.56 (0.37–0.86) | 0.008* | 0.63 (0.40–1.00) | 0.051 |
 50- | 7365 | 579 | 78,045 | 7.42 |  |  |  |  |
  Q1 | 1188 | 114 | 12,693 | 8.98 | 1.00 |  | 1.00 |  |
  Q2 | 1971 | 164 | 21,016 | 7.80 | 0.87 (0.69–1.11) | 0.260 | 0.91 (0.72–1.16) | 0.440 |
  Q3 | 2084 | 140 | 22,157 | 6.32 | 0.67 (0.52–0.86) | 0.001* | 0.70 (0.54–0.91) | 0.007* |
  Q4 | 2122 | 161 | 22,179 | 7.26 | 0.72 (0.56–0.92) | 0.008* | 0.79 (0.61–1.02) | 0.071 |
 60- | 5666 | 1027 | 59,177 | 17.35 |  |  |  |  |
  Q1 | 2081 | 429 | 21,372 | 20.07 | 1.00 |  | 1.00 |  |
  Q2 | 1600 | 272 | 16,770 | 16.22 | 0.82 (0.70–0.96) | 0.012* | 0.83 (0.71–0.96) | 0.015* |
  Q3 | 1143 | 196 | 12,274 | 15.97 | 0.78 (0.66–0.92) | 0.004* | 0.78 (0.66–0.93) | 0.006* |
  Q4 | 842 | 130 | 8761 | 14.84 | 0.67 (0.55–0.82) | < 0.001* | 0.69 (0.56–0.85) | < 0.001* |
 ≥ 70 | 2110 | 632 | 20,637 | 30.62 |  |  |  |  |
  Q1 | 1186 | 370 | 11,351 | 32.60 | 1.00 |  | 1.00 |  |
  Q2 | 590 | 181 | 5895 | 30.70 | 0.96 (0.80–1.15) | 0.674 | 0.97 (0.81–1.16) | 0.712 |
  Q3 | 239 | 57 | 2403 | 23.72 | 0.71 (0.54–0.94) | 0.016* | 0.70 (0.53–0.93) | 0.014* |
  Q4 | 95 | 24 | 988 | 24.29 | 0.70 (0.47–1.07) | 0.097 | 0.71 (0.47–1.09) | 0.115 |