Skip to main content

Table 2 Methodological characteristics of included systematic reviews

From: Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

Document Document Type Stated purpose Themes Studies reviewed related to naloxone Year of last study reviewed RCTs Meta-analysis
Bahji_2018 [27] Systematic review To synthesize findings and provide a systematic review of interventions for the treatment and prevention of opioid overdose. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal 4 2016 12 No
Behar_2018 [28] Systematic review To assess the acceptability and feasibility of prescribing naloxone to patients in primary care settings. Provision, feasibility and acceptability of naloxone distribution 17 2017 No
Chimbar_2018 [29] Systematic review To examine the effectiveness of naloxone take-home kits and their effect in reducing fatal overdoses among those who use opioids. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal 9 2016 2 No
Chou_2017 [30] Systematic review To synthesize evidence on 1) the effects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital settings on mortality, reversal of overdose, and harms, and 2) the need for transport to a health care facility after reversal of overdose with naloxone. Naloxone dosing or routes of administration
Overdose response after naloxone administration
13 2016 3 No
Clark_2014 [31] Systematic review To describe the current state of the literature on community-based opioid overdose programs (OOPPs) with a focus on the effectiveness of these programs. This article reviews characteristics and outcomes of OOPPs. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal
Naloxone training and education
19 2013 No
Eizadi-Mood_2019 [32] Systematic review To examine the relationship between naloxone and seizure in tramadol poisoning. Naloxone safety (harms or adverse events related to naloxone administration) 7 2015 1 Yes
EMCDDA_2015 [11] Systematic review To assess the effect of take-home emergency naloxone and educational intervention on knowledge improvement, naloxone use, management of overdoses witnessed and death as a result of overdose. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal
Naloxone training and education
21 2014 1 No
Giglio_2015 [33] Systematic review To synthesize the quantitative findings of available studies to generate a summary estimate of the effectiveness of bystander naloxone administration and overdose education programs using meta-analytic methods. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal
Naloxone training and education
9 2014 1 Yes
Greene_2019 [34] Systematic review To determine mortality and serious adverse events within 48 h of EMS treat and release due to suspected rebound opioid toxicity after naloxone administration. Overdose response after naloxone administration 7 2017 Yes
Gunn_2018 [35] Systematic review To assess the effectiveness of the Emergency Department as a potential setting for naloxone distribution for overdose reversal. The purpose of this systematic review was to identify, evaluate, and summarize available evidence regarding the distribution of take-home naloxone in the ED and identify the areas that require future research. Provision, feasibility and acceptability of naloxone distribution 5 2016 1 No
Haegerich_2019 [36] Systematic review To assess systems-level interventions to address provider and patient/public behavior and prevent prescription and illicit opioid overdose, naloxone education and distribution Provision, feasibility and acceptability of naloxone distribution 65 2019 1 No
McAuley_2015 [37] Systematic review To assess the impact of take-home naloxone at a global level, in order to give effect sizes that could be extrapolated to different populations across the world. Provision, feasibility and acceptability of naloxone distribution 9 2012 9 Yes
McDonald_2016 [9] Systematic review To assess the effectiveness of take-home naloxone (THN), addressing the following two aims: [25] to describe the impact of THN provision on overdose related mortality in opioid users; and [1] to assess the safety of THN provision by quantifying adverse events associated with naloxone administration. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal
Naloxone safety (harms or adverse events related to naloxone administration)
Cost-effectiveness
2015 No
Mitchell _2016 [38] Systematic review To identify trends in the current literature, gaps in the findings, nursing implications, and opportunities for further exploration related to the use of naloxone in opioid overdose. Effectiveness of naloxone and take-home naloxone (THN) for opioid overdose reversal 8 2015 7 No
Moe_2020 [39] Systematic review To evaluate the relationship between naloxone dose (initial and cumulative) and opioid toxicity reversal and adverse events in undifferentiated and presumed fentanyl/ ultra-potent opioid overdoses. Naloxone dosing or routes of administration No date 7 No
Ryan_2018 [40] Systematic review To assess the pharmacokinetic properties of community-use formulations of naloxone for emergency treatment of opioid overdose. Naloxone dosing or routes of administration 7 2017 7 No
Smart_2020 [41] Systematic review The review describes demographic and clinical characteristics of opioid overdose prevention program (OOPP) participants, describes OOPP curriculums and addresses the following questions: [25] Do OOPPs with naloxone distribution reduce fatal and nonfatal overdose rates among participants? [1] Are OOPPs effective at increasing nonmedical bystander knowledge of prevention, risk factors, and recognition of opioid overdose? [2] Do nonmedical bystanders trained at OOPPs respond correctly to witnessed opioid overdoses? Provision, feasibility and acceptability of naloxone distribution 11 2019 No
Strang_2016 [42] Systematic review To examine the options for non-injectable naloxone with potential application for wider community-based opioid overdose reversal. Naloxone dosing or routes of administration 21 2015 No
Thakur_2020 [43] Systematic review To examine the current state of naloxone use and dispensing regarding [25] roles for pharmacists dispensing naloxone, [1] barriers to their dispensing naloxone, and [2] pharmacist training to dispense naloxone. Provision, feasibility and acceptability of naloxone distribution 33 2018 No
Yousefifard_2019 [44] Systematic review To compare the efficacy of the intranasal administration of naloxone with its intramuscular/intravenous administration in the pre hospital management of opioid overdose. Naloxone dosing or routes of administration 6 2014 3 Yes