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Table 5 Multivariate analysis of factors associated with LTFU among HIV-infected adults on antiretroviral therapy

From: Factors associated with 36-month loss to follow-up and mortality outcomes among HIV-infected adults on antiretroviral therapy in Central Kenya

 

Multivariate Results (n = 23890)

6 months

12 months

24 months

36 months

aOR (95% CI)

P value

aOR (95% CI)

P value

aOR (95% CI)

P value

aOR (95% CI)

P value

Gender

 Male

1.23 (1.12–1.36)

< 0.001

1.19 (1.10–1.29)

< 0.001

1.19 (1.1–1.27)

< 0.001

1.19 (1.12–1.27)

< 0.001

 Female

Ref

 

Ref

 

Ref

 

Ref

 

BMI

  < 18.5

1.52 (1.3–1.78)

< 0.001

2.51 (1.88–3.36)

< 0.001

2.02 (1.63–2.5)

< 0.001

1.68 (1.39–2.02)

< 0.001

 18.5–24.9

Ref

 

Ref

 

Ref

 

Ref

 

 25–29.9

0.58 (0.43–0.77)

< 0.001

0.61 (0.49–0.77)

< 0.001

0.66 (0.55–0.79)

< 0.001

0.69 (0.6–0.79)

< 0.001

 30+

0.50 (0.37–0.69)

< 0.001

0.55 (0.42–0.71)

< 0.001

0.62 (0.52–0.75)

< 0.001

0.69 (0.58–0.82)

< 0.001

Age

 20–35

1.23 (1.12–1.35)

< 0.001

1.36 (1.26–1.47)

< 0.001

1.47 (1.37–1.57)

< 0.001

1.49 (1.40–1.59)

< 0.001

 36–50

Ref

 

Ref

 

Ref

 

Ref

 

 51+

1.03 (0.88–1.2)

0.719

1.00 (0.87–1.14)

0.960

0.98 (0.87–1.1)

0.665

0.99 (0.89–1.10)

0.803

Marital Status

 Single

1.34 (1.19–1.51)

< 0.001

1.31 (1.18–1.45)

< 0.001

1.26 (1.15–1.38)

< 0.001

1.34 (1.23–1.45)

< 0.001

 Divorced

1.35 (1.19–1.53)

< 0.001

1.31 (1.17–1.46)

< 0.001

1.30 (1.19–1.43)

< 0.001

1.25 (1.15–1.36)

< 0.001

 Married

Ref

 

Ref

 

Ref

 

Ref

 

 Widowed

1.01 (0.87–1.18)

0.859

0.99 (0.87–1.12)

0.814

1.02 (0.91–1.14)

0.726

1.03 (0.93–1.14)

0.555

CD4

 0–250

1.34 (1.16–1.55)

< 0.001

1.33 (1.17–1.5)

< 0.001

1.15 (1.05–1.27)

0.004

1.18 (1.08–1.29)

< 0.001

 251–500

Ref

 

Ref

 

Ref

 

Ref

 

 Above 500

1.42 (0.81–2.49)

0.215

1.22 (0.73–2.05)

0.448

1.42 (0.93–2.16)

0.102

1.33 (0.90–1.96)

0.149

Regimen Started

 D4T-based

Ref

 

Ref

 

Ref

 

Ref

 

 ABC-based

2.37 (1.82–3.08)

< 0.001

2.44 (1.93–3.09)

< 0.001

2.33 (1.87–2.90)

< 0.001

2.17 (1.75–2.69)

< 0.001

 AZT-based

0.74 (0.65–0.83)

< 0.001

0.75 (0.67–0.83)

< 0.001

0.78 (0.71–0.85)

< 0.001

0.85 (0.79–0.93)

< 0.001

 TDF-based

0.62 (0.55–0.69)

< 0.001

0.67 (0.61–0.74)

< 0.001

0.73 (0.68–0.8)

< 0.001

0.86 (0.80–0.92)

< 0.001

Baseline WHO Stage

 Stage I

Ref

 

Ref

 

Ref

 

Ref

 

 Stage II

1.03 (0.87–1.22)

0.732

1.08 (0.95–1.24)

0.242

1.07 (0.96–1.19)

0.251

1.07 (0.98–1.17)

0.147

 Stage III

1.34 (1.14–1.57)

< 0.001

1.31 (1.16–1.48)

< 0.001

1.25 (1.13–1.39)

< 0.001

1.22 (1.12–1.34)

< 0.001

 Stage IV

1.83 (1.48–2.26)

< 0.001

1.57 (1.31–1.88)

< 0.001

1.38 (1.17–1.62)

< 0.001

1.34 (1.15–1.57)

< 0.001