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Table 3 Summary of findings table Female condom + male condom compared to Male condom only for prevention of HIV an STIs Patient or population: prevention of HIV an STIs Intervention: Female condom + male condom Comparison: Male condom only

From: Effectiveness of the female condom in preventing HIV and sexually transmitted infections: a systematic review and meta-analysis

Outcome № of participants

(studies)

Relative effect

(95% CI)

Anticipated absolute effects (95% CI)

Certainty

  

Difference

HIV infection

№ of participants: 149

(1 RCT)

RR 0.07

(0.00 to 1.38)

6.0%

0.4%

(0 to 8.3)

5.6% fewer

(6 fewer to 2.3 more)

LOW a

Any STI

№ of participants: 2232

(3 RCTs)

RR 0.74

(0.62 to 0.89)

24.9%

18.4%

(15.5 to 22.2)

6.5% fewer

(9.5 fewer to 2.7 fewer)

MODERATE b

Gonorrhoea

№ of participants: 790

(2 RCTs)

RR 0.59

(0.41 to 0.86)

15.2%

9.0%

(6.2 to 13.1)

6.2% fewer

(9 fewer to 2.1 fewer)

HIGH

Chlamydia

№ of participants: 790

(2 RCTs)

RR 0.67

(0.47 to 0.94)

16.0%

10.7%

(7.5 to 15)

5.3% fewer

(8.5 fewer to 1 fewer)

HIGH

Trichomonas

№ of participants: 790

(2 RCTs)

RR 1.01

(0.63 to 1.60)

8.0%

8.1%

(5 to 12.8)

0.1% more

(3 fewer to 4.8 more)

MODERATE a

Genital ulcer disease

№ of participants: 457

(1 RCT)

RR 4.72 (0.23 to 97.87)

0.0%

0.0%

(0 to 0)

0.0% fewer

(0 fewer to 0 fewer)

MODERATE a

  1. CI Confidence interval; RR: Risk ratio
  2. GRADE Working Group grades of evidence
  3. High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
  4. Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
  5. Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
  6. Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  7. Explanations
  8. aIncludes only one study with small sample size and wide confidence intervals
  9. bHigh risk of selection bias due to lack of proper randomization in one of the trials