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Table 1 Clinical and biochemical characteristics between the study groups before and after intervention

From: Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial

Anthropometric CharacteristicsIndividual Group (n = 65)Familiar Group (n = 57)
Basal (n = 65)Month 6 (n = 48)Month 12 (n = 39)Basal (n = 57)Month 6 (n = 42)Month 12 (n = 32)
Weight (kg)81.8 ± 17.075.4 ± 17.5B76.7 ± 19.8 C82.1 ± 18.078.5 ± 19.0 E76.2 ± 15.0 F
BMI (kg/m2)30.2 ± 5.328.3 ± 5.5B28.9 ± 6.5 C30.3 ± 5.829.2 ± 6.0 E28.6 ± 4.6F
WC (cm)95.3 ± 12.091.5 ± 12.4 B93.5 ± 13.596.2 ± 14.092.8 ± 17.492.8 ± 10.5
Body fat (%)34.8 ± 8.332.7 ± 8.8 B35.6 ± 7.634.8 ± 8.333.6 ± 9.0 E34.5 ± 9.0
Visceral Index (AU)11.0 ± 4.89.8 ± 4.6B11.3 ± 4.911.3 ± 4.611.0 ± 4.7 E10.6 ±
4.3 F
SBP (mm Hg)123 ± 16119 ± 16.7121 ± 14116 ± 11113 ± 12122 ± 15
Biochemistry Characteristics
Glucose (mg/dl) 0 min101 ± 1097 ± 10B94 ± 10C104 ± 997 ± 11 E98 ± 8 F
Glucose (mg/dl) 120 min146 ± 23131 ± 45B127 ± 33C149 ± 27135 ± 35E142 ± 33
HbA1c (%)5.3 ± 0.55.4 ± 0.35.4 ± 0.35.1 ± 0.75.5 ± 0.4E5.4 ± 0.3 F
AUCgluc_OGTT (mg/dl/120 min)18,398 ± 240317,749 ± 396517,204 ± 342918,597 ± 261117,637 ± 3849E17,237 ± 2792F
Tg (mg/dl)159 ± 79135 ± 58148 ± 58192 ± 90167 ± 79210 ± 164
Total Cholesterol (mg/dl)181 ± 34177 ± 35∆H183 ± 35∆I197 ± 40186 ± 38E, ∆H186 ± 35F∆I
HDL (mg/dl)40 ± 1144 ± 1339 ± 1442 ± 1144 ± 1644 ± 12
LDL (mg/dl)112 ± 33108 ± 27118 ± 32∆I121 ± 36108 ± 33E106 ± 38F, ∆I
Markers of insulin resistance and pancreatic β-cell function
 Matsuda Index3.9 ± 1.94.8 ± 2.6B4.9 ± 3.0C3.5 ± 2.34.9 ± 3.5E4.7 ± 3.5F
 HOMA IR2.9 ± 2.02.4 ± 1.9B2.4 ± 1.7C3.5 ± 2.02.9 ± 3.43.1 ± 2.7
 Insulin secretion0.45 ± 0.200.44 ± 0.220.49 ± 0.25∆I0.58 ± 0.380.48 ± 0.260.50 ± 0.27∆I
 Disposition Index1.5 ± 0.41.8 ± 0.7B1.9 ± 0.7C∆I1.5 ± 0.51.9 ± 0.9E1.7 ± 0.5∆I
 Oral Disposition Index0.11 ± 0.120.15 ± 0.180.08 ± 0.140.13 ± 0.130.11 ± 0.120.11 ± 0.06
  1. Data presented as means ± standard deviation. A = p < 0.05 between groups at the corresponding time; B = p < 0.05 basal vs month 6 individual group; C = p < 0.05 basal vs month 12 individual group; D = p < 0.05 month 6 vs month 12 individual group; E = p < 0.05 basal vs month 6 familiar group; F = p < 0.05 basal vs month 12 familiar group; G = p < 0.05 month 6 vs month 12 familiar group; ∆H = p < 0.05 for comparison of change between groups from 0 to 6 months; ∆I = p < 0.05 for comparison of change between groups from 0 to 12 months. AU, arbitrary units; AUCgluc_OGTT, area under the glucose curve during oral glucose tolerance test; AUCIns, area under the insulin; BMI, body mass index; HbA1c, Glycated hemoglobin; HDL, high density lipoprotein; HOMA IR, homeostatic model assessment; IR, insulin resistance; LDL, low density lipoprotein; SBP, systolic pression blood; Tg, triglycerides; WC, waist circumference
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