Table 1 MCCV effectiveness within and over 1 year following vaccination of included studies

 UK, 2000–2004 (Trotter 2004) [30]

Routine 3 doses (at 2, 3 and 4 months)

93% (67 to 99)

−81% (−7430 to71)

 UK, 2000–2009 (Campbell 2010) [27]

Routine 3 doses (at 2, 3, and 4 months)

97% (91 to 99)

68% (− 63 to 90)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Routine 3 doses (at 2,4 and 6 months)

98% (95 to 99)

81% (67 to 90)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Routine 3 doses (at 2,5 and > 12 months)

100% (98 to 100)

89% (− 23 to 99)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Routine 1–3 doses (at < 20 years)

99% (98 to 99)

91% (88 to 93)

 UK, 2000–2004 (Trotter 2004) [30]

Catch-up 2 doses (2 doses at 5-12 months)

87% (11 to 99)

82% (−8 to 97)

 UK, 2000–2009 (Campbell 2010) [27]

Catch-up 2 doses (2 doses at 5-12 months)

91% (− 8 to 100)

84% (31 to 97)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Catch-up 2 doses (at 1–5 years)

99% (94 to 100)

91% (69 to 97)

 UK, 2000–2004 (Trotter 2004) [30]

Catch-up 1 dose (at 1–2 years)

88% (65 to 96)

61% (− 327 to 94)

 UK, 2000–2004 (Trotter 2004) [30]

Catch-up 1 dose (at 3–4 years)

98% (90 to 100)

93% (78 to 98)

 UK, 2000–2004 (Trotter 2004) [30]

Catch-up 1 dose (at 11–16 years)

96% (89 to 99)

90% (77 to 96)

 UK, 2000–2009 (Campbell 2010) [27]

Catch-up 1 dose (at 1–2 years)

89% (64 to 98)

71% (− 40 to 93)

 UK, 2000–2009 (Campbell 2010) [27]

Catch-up 1 dose (at 3–18 years)

96% (92 to 99)

93% (87 to 96)

 Spain 1999–2004 (Larrauri 2005) [39]

Catch-up 1 dose (at 7 months-5 years)

100% (98 to 100)

94% (71 to 99)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Catch-up 1 dose (at 6–12 months)

99% (95 to 100)

93% (87 to 96)

 Spain 2001–2013 (Garrido-Estepa 2014) [32]

Catch-up 1 dose (at 6–20 years)

100% (100 to 100)

96% (91 to 98)