Table 4 Survival analysis and hazard ratios for 582 patients diagnosed with cirrhosis in Halland 2011–2018
Mean transplantation-free survival in years (95% CI) | Univariate analyses Hazard ratio (95% CI) | Multivariate analysis 1 Hazard ratio (95% CI) | Multivariate analysis 2 Hazard ratio (95% CI) | |
|---|---|---|---|---|
Sex | ||||
Female | 4.82 (4.29–5.35) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Male | 3.81 (3.42–4.20) | 1.42 (1.12–1.78) | 1.37 (1.03–1.81) | 1.28 (0.96–1.66) |
Age | ||||
18–44 | 6.17 (4.68–7.66) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
45–49 | 6.10 (5.13–7.06) | 1.08 (0.41–2.84) | 1.55 (0.58–4.17) | 1.57 (0.59–4.22) |
50–54 | 5.23 (4.10–6.37) | 1.63 (0.69–3.88) | 2.70 (1.08–6.75) | 2.69 (1.08–6.73) |
55–59 | 5.06 (4.11–6.01) | 1.81 (0.80–4.11) | 3.73 (1.57–8.83) | 3.50 (1.49–8.27) |
60–64 | 4.79 (4.03–5.54) | 2.00 (0.91–4.41) | 3.85 (1.67–8.85) | 3.61 (1.58–8.25) |
65–69 | 4.48 (3.79–5.16) | 2.17 (0.99–4.76) | 5.67 (2.38–13.5) | 5.52 (2.31–13.2) |
70–74 | 3.68 (2.86–4.50) | 2.97 (1.34–6.60) | 7.75 (3.15–19.0) | 7.23 (2.96–17.7) |
75–79 | 2.80 (1.97–3.63) | 4.07 (1.83–9.07) | 9.60 (3.86–23.8) | 9.50 (3.84–23.5) |
80+ | 1.13 (0.80–1.46) | 7.97 (3.64–17.5) | 14.6 (5.82–36.5) | 14.5 (5.79–36.1) |
Socioeconomic and marital status | ||||
Marital status | ||||
Married | 4.56 (4.14–4.98) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Never married | 3.97 (3.31–4.63) | 1.24 (0.96–1.61) | 1.05 (0.78–1.42) | 1.06 (0.79–1.44) |
Previously married | 3.35 (2.69–4.01) | 1.50 (1.14–1.96) | 1.03 (0.76–1.40) | 1.08 (0.80–1.46) |
Employment status | ||||
Employed | 5.74 (5.17–6.32) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Pensioner | 3.28 (2.85–3.70) | 2.39 (1.81–3.16) | 0.89 (0.60–1.32) | 0.88 (0.59–1.30) |
Disability retired | 3.63 (2.91–4.35) | 2.10 (1.49–2.95) | 1.44 (0.96–2.16) | 1.54 (0.99–2.24) |
Unemployed | 4.30 (3.15–5.45) | 1.63 (1.02–2.59) | 0.92 (0.50–1.69) | 1.20 (0.71–2.02) |
Occupational skill level | ||||
I | 3.00 (2.33–3.67) | 3.50 (2.14–5.73) | 3.43 (1.89–6.23) | Excluded from the analysis |
II | 4.04 (3.64–4.45) | 2.42 (1.53–3.84) | 2.48 (1.48–4.12) | Excluded from the analysis |
III | 4.78 (3.93–5.67) | 1.72 (0.98–3.03) | 1.87 (1.00–3.46) | Excluded from the analysis |
IV | 6.39 (5.54–7.23) | 1.00 (reference) | 1.00 (reference) | Excluded from the analysis |
I-II (aggregated) | 3.79 (3.44–4.14) | 1.98 (1.47–2.68) | Excluded from the analysis | 1.85 (1.32–2.61) |
III-IV (aggregated) | 5.64 (5.00–6.28) | 1.00 (reference) | Excluded from the analysis | 1.00 (reference) |
Aetiologies | ||||
Alcohol | 4.10 (3.67–4.53) | 2.83 (1.39–5.76) | 1.63 (0.68–3.90) | 1.71 (0.72–4.09) |
Cryptogenic | 1.80 (1.24–2.36) | 6.67 (3.20–13.9) | 2.89 (1.17–7.13) | 3.01 (1.22–7.43) |
Hepatitis C | 5.32 (4.48–6.15) | 1.81 (0.84–3.88) | 1.97 (0.77–5.03) | 2.16 (0.85–5.49) |
PBC | 6.40 (5.23–7.57) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
NAFLD | 2.80 (1.95–3.65) | 3.87 (1.70–8.80) | 2.55 (0.95–6.86) | 2.74 (1.02–7.36) |
AIH | 5.41 (3.99–6.84) | 1.77 (0.73–4.28) | 1.96 (0.70–5.50) | 2.01 (0.72–5.60) |
Other causes | 4.74 (3.49–5.98) | 2.09 (0.90–4.89) | 2.20 (0.82–5.92) | 2.51 (0.94–6.71) |
Severitya | ||||
MELD | ||||
MELD < 10 | 5.60 (5.09–6.11) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
MELD 10–14 | 4.21 (3.57–4.85) | 1.66 (1.22–2.26) | 1.25 (0.88–1.77) | 1.28 (0.90–1.61) |
MELD ≥15 | 2.87 (2.40–3.34) | 2.69 (2.06–3.50) | 1.05 (0.73–1.52) | 1.08 (0.74–1.54) |
Child-Pugh class | ||||
A | 6.46 (5.99–6.92) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
B | 3.24 (2.77–3.71) | 3.41 (2.55–4.55) | 2.35 (1.68–3.29) | 2.38 (1.70–3.34) |
C | 2.19 (1.64–2.76) | 5.37 (3.91–7.36) | 5.75 (3.67–9.02) | 5.93 (3.78–9.31) |