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Table 3 Analysis of Risk Factors for Preeclampsia in the First and Second Trimester of Pregnancy

From: Association of Ambient air Pollution with risk of preeclampsia during pregnancy: a retrospective cohort study

EC

N (PE/Total)

Unadjusted Model

Adjusted Model

OR (95% CI)

P

AOR (95% CI)

P

PM2.5

 Trimester 1

1.027 (1.018–1.037)

< 0.001

1.014 (1.000–1.028)

0.005

  Q 1

553/28225

Reference

 

Reference

 

  Q 2

856/29721

1.541 (1.381–1.719)

< 0.001

1.254 (1.120–1.405)

< 0.001

  Q 3

786/29102

1.442 (1.290–1.612)

< 0.001

1.225 (1.081–1.388)

0.001

  Q 4

813/28994

1.499 (1.342–1.647)

<  0.001

1.235 (1.064–1.434)

0.006

 Trimester 2

1.034 (1.024–1.043)

< 0.001

1.026 (1.012–1.049)

< 0.001

  Q 1

570/ 29,262

Reference

 

Reference

 

  Q 2

814/ 29,033

1.452 (1.303–1.618)

< 0.001

1.173 (1.038–1.325)

0.010

  Q 3

773/ 28,830

1.387 (1.243–1.547)

< 0.001

1.179 (1.039–1.338)

0.011

  Q 4

831/ 28,917

1.489 (1.337–1.659)

< 0.001

1.324 (1.142–1.535)

< 0.001

PM10

 Trimester 1

 

1.021 (1.014–1.028)

< 0.001

1.013 (1.002–1.023)

0.021

  Q 1

550/29364

Reference

 

Reference

 

  Q 2

781/28742

1.463 (1.310–1.634)

< 0.001

1.269 (1.131–1.423)

< 0.001

  Q 3

862/29440

1.580 (1.418–1.761)

< 0.001

1.401 (1.231–1.594)

< 0.001

  Q 4

795/28496

1.504 (1.347–1.678)

<  0.001

1.429 (1.228–1.664)

< 0.001

 Trimester 2

 

1.024 (1.017–1.031)

< 0.001

1.016 (1.005–1.027)

< 0.001

  Q 1

602/29152

Reference

 

Reference

 

  Q 2

779/28350

1.340 (1.203–1.492)

< 0.001

1.098 (0.982–1.228)

0.099

  Q 3

811/29599

1.336 (1.201–1.486)

< 0.001

1.163 (1.020–1.326)

0.024

  Q 4

796/28941

1.341 (1.205–1.493)

< 0.001

1.094 (0.950–1.260)

0.201

NO2

 Trimester 1

 

1.040 (1.016–1.066)

0.001

1.046 (1.003–1.091)

0.034

  Q 1

668/28909

Reference

 

Reference

 

  Q 2

793/29415

1.171 (1.055–1.300)

0.003

1.159 (1.034–1.299)

0.011

  Q 3

796/30061

1.150 (1.036–1.276)

0.009

1.223 (1.071–1.396)

0.003

  Q 4

731/27657

1.148 (1.032–1.276)

< 0.011

1.292 (1.101–1.512)

0.002

 Trimester 2

 

1.054 (1.029–1.080)

< 0.001

1.056 (1.010–1.105)

0.017

  Q 1

784/ 30,347

Reference

 

Reference

 

  Q 2

723/ 28,503

0.981 (0.886–1.087)

0.719

0.890 (0.796–0.994)

0.039

  Q 3

661/ 28,049

0.910 (0.820–1.011)

0.078

0.894 (0.779–1.025)

0.110

  Q 4

820/ 29,143

1.092 (0..989–1.206)

0.083

0.934 (0.791–1.103)

0.421

SO2

 Trimester 1

 

1.012 (0.994–1.030)

0.204

1.013 (0.985–1.068)

0.361

  Q 1

761/29302

Reference

 

Reference

 

  Q 2

713/28691

0.956 (0.862–1.060)

0.392

1.024 (0.908–1.156)

0.698

  Q 3

769/29332

1.010 (0.912–1.118)

0.852

1.051 (0.919–1.201)

0.469

  Q 4

745/28717

0.999 (0.902–1.107)

0.983

0.954 (0.804–1.131)

0.588

 Trimester 2

 

1.021 (1.002–1.041)

0.031

1.050 (1.019–1.082)

0.002

  Q 1

752/ 28,886

Reference

 

Reference

 

  Q 2

711/ 29,067

0.938 (0.846–1.041)

0.228

1.059 (0.937–1.198)

0.357

  Q 3

741/ 29,978

0.948 (0.856–1.051)

0.310

1.164 (1.022–1.326)

0.022

  Q 4

784/ 28,111

1.073 (0.970–1.188)

0.171

1.317 (1.119–1.551)

0.001

CO

 Trimester 1

 

0.943 (0.743–1.195)

0.625

1.297 (0.910–1.849)

0.151

  Q 1

792/28820

Reference

 

Reference

 

  Q 2

780/30067

0.943 (0.853–1.042)

0.247

1.084 (0.965–1.218)

0.172

  Q 3

640/28112

0.824 (0.742–0.916)

< 0.001

1.083 (0.947–1.237)

0.245

  Q 4

776/29043

0.972 (0.879–1.074)

0.573

1.139 (0.969–1.338)

0.114

 Trimester 2

 

1.305 (1.034–1.648)

0.025

2.305 (1.602–3.317)

< 0.001

  Q 1

844/ 30,607

Reference

 

Reference

 

  Q 2

652/ 27,083

0.870 (0.784–0.965)

0.008

1.019 (0.904–1.149)

0.759

  Q 3

679/ 28,681

0.855 (0.772–0.947)

0.003

1.160 (1.016–1.324)

0.029

  Q 4

813/ 29,671

0.993 (0.901–1.095)

0.896

1.238 (1.038–1.475)

0.017

O3

 Trimester 1

 

1.021 (1.013–1.029)

< 0.001

1.024 (1.010–1.037)

0.001

  Q 1

653/ 28,869

Reference

 

Reference

 

  Q 2

726/ 29,512

1.090 (0.979–1.213)

0.115

1.205 (1.052–1.382)

0.007

  Q 3

816/ 29,378

1.234 (1.112–1.370)

< 0.001

1.324 (1.136–1.544)

< 0.001

  Q 4

793/ 28,283

1.246 (1.122–1.384)

<  0.001

1.334 (1.132–1.574)

0.001

 Trimester 2

 

1.010 (1.003–1.017)

0.006

1.016 (1.003–1.029)

0.013

  Q 1

732/ 29,538

Reference

 

Reference

 

  Q 2

712/ 28,467

1.010 (0.909–1.121)

0.859

1.214 (1.072–1.375)

0.002

  Q 3

756/ 29,362

1.040 (0.938–1.153)

0.455

1.177 (1.011–1.369)

0.035

  Q 4

788/ 28,675

1.112 (1.004–1.231)

0.041

1.239 (1.035–1.483)

0.020

  1. There were 113,054 parturients in Non-PE group, and 2988 parturients in PE group. The concentration of exposed ambient air pollutants (PM2.5, PM10, NO2, SO2, CO, O3) was stratified into four groups according to the quartile (Q1, Q2, Q3, Q4); Q1 acted as the reference, univariate logistic regression was used to examine the strength of association between exposure to air pollutants and preeclampsia; In adjusted model, trimester, gravidity, parity, age, education, hospital level, conception and delivery season were adjusted. PE preeclampsia, OR Odds ratio, CI confidence intervals, Trimester 1 the first trimester of pregnancy, Trimester 2 the second trimester of pregnancy