Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa: the “PrEP as a bridge to ART” strategy

Musinguzi, Nicholas; Kidoguchi, Lara; Mugo, Nelly R.; Ngure, Kenneth; Katabira, Elly; Celum, Connie L.; Baeten, Jared M.; Heffron, Renee; Haberer, Jessica E.

doi:10.1186/s12889-020-09712-3

Table 3 Correlates of PrEP use beyond the recommendation to stop (n = 230)

From: Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa: the “PrEP as a bridge to ART” strategy

Characteristics		Univariable		Multivariable
	N (%) or Median (IQR)	OR (95% CI)	p-value	OR (95% CI)	p-value
Stopped as recommended	60
*Participant*
Female	10 (17)	0.4 (0.2, 0.9)	0.034	0.6 (0.2, 1.5)	0.26
Age at screening (per 5 years)	29 (25, 35)	0.8 (0.7, 1.0)	0.015	0.8 (0.7, 1.0)	0.076
Education (years)	8.5 (8, 12)	1.1 (1.0, 1.2)	0.001	1.1 (1.0, 1.2)	0.029
Married to study partner	58 (97)	1.6 (0.3, 7.8)	0.55
Number of children with study partner	0 (0,1)	0.8 (0.7, 1.1)	0.12	1.2 (0.9, 1.6)	0.22
At enrolment couple had been aware of discordance status for > 1 month	45 (75)	1.2 (0.6, 2.3)	0.68
Probable depression^a [15]	5 (8)	0.9 (0.3, 2.7)	0.91
Desire children now or in future	51 (85)	2.9 (1.3, 6.2)	0.008	2.2 (0.8, 6.3)	0.15
Problematic alcohol consumption^b [16]	14 (23)	1.4 (0.7, 2.9)	0.34
Relationship satisfaction score^c [17]	27 (23, 28)	1.0 (0.9, 1.1)	0.54
How difficult was it for you to learn that your partner has HIV while you do not	–	1.2 (0.9, 1.6)	0.18	0.9 (0.6, 1.4)	0.66
How much of a challenge did this discovery create for your relationship?	–	1.3 (0.9.1.8)	0.12	1.2 (0.8, 1.8)	0.50
How well are you managing the situation now?	–	0.6 (0.4, 0.9)	0.025	0.6 (0.4, 1.0)	0.046
PrEP makes sex safe from HIV	22 (37)	0.6 (0.3, 1.0)	0.055	0.5 (0.2, 0.9)	0.026
No fears or concerns about daily PrEP	54 (90)	1.1 (0.4, 3.0)	0.80
Preference for HIV prevention
Prefer partner start ARVs	6 (10)	ref		ref
Prefer to use daily PrEP	54 (90)	2.0 (0.8, 5.3)	0.12	3.6 (1.2, 11.2)	0.026
Had some perceived risk of getting or transferring HIV to partner	39 (39)	1.2 (0.7, 2.2)	0.55
High risk sexual behavior ^d (sex + < 100% condom use)	4 (2, 7)	1.0 (1.0, 1.1)	0.40
*Partner living with HIV*
Probable depression^a [15]	9 (15)	1.1 (0.5, 2.5)	0.87
Problematic alcohol consumption^b [16]	4 (7)	0.3 (0.1, 1.0)	0.040	0.6 (0.2, 1.9)	0.36
PrEP makes sex safe from HIV	28 (47)	0.9 (0.5, 1.6)	0.72

^a Scoring an average of ≥ 1.75 on the Hopkins Depression Symptoms checklist was considered probable depression
^bA participant who provides a positive response to any one of the four Rapid Alcohol Problems Screen (RAPS4) questions is considered to have problematic alcohol consumption
^cThe relationship satisfaction score ranges from 0 to 40 with higher values indicating more satisfaction
^d The number of sexual acts without a condom during the past month

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ISSN: 1471-2458

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