Table 1 Sample characteristics at baseline by adherence status
Characteristic | Unmatcheda | Matcheda | ||||
|---|---|---|---|---|---|---|
Adherent | Non-adherent | SMD | Adherent | Non-adherent | SMD | |
Frequency of patients, n (%) | 20,613 | 31,894 | 19,943 | 15,631 | ||
Sex | ||||||
Female | 13,914 (67.5) | 19,983 (62.7) | 0.103 | 13,464 (67.5) | 10,351 (66.2) | 0.032 |
Male | 6699 (32.5) | 11,911 (37.3) | 0.103 | 6479 (32.5) | 5280 (33.8) | 0.032 |
Age in years, mean (SD) | 56.1 (10.2) | 56.4 (10.4) | 0.034 | 56.1 (10.2) | 56.2 (10.4) | 0.011 |
Overweight or obesity (BMI > 25) | 13,356 (64.9) | 21,023 (66) | 0.024 | 13,001 (65.2) | 10,337 (66.1) | 0.004 |
Diagnosis at baseline | ||||||
Hypertension | 19,796 (96) | 30,010 (94.1) | 0.1 | 19,179 (96.2) | 14,904 (95.3) | 0.074 |
Diabetes millitus type 2 | 4224 (20.5) | 10,983 (34.4) | 0.345 | 4061 (20.4) | 4033 (25.8) | 0.135 |
Dyslipidemia | 4759 (23.1) | 13,962 (43.8) | 0.491 | 4681 (23.5) | 5084 (32.5) | 0.075 |
Chronic kidney disease | 2326 (11.3) | 3226 (10.1) | 0.037 | 2252 (11.3) | 1560 (10) | 0.003 |
Prevalence groups | ||||||
HTA | 10,733 (52.1) | 9074 (28.5) | 0.473 | 10,353 (51.9) | 6542 (41.9) | 0.038 |
HTA + Dyslipidemia | 3665 (17.8) | 9329 (29.3) | 0.3 | 3603 (18.1) | 3782 (24.2) | 0.086 |
HTA + DM | 2432 (11.8) | 5037 (15.8) | 0.124 | 2340 (11.7) | 2202 (14.1) | 0.102 |
HTA + DM + Dyslipidemia | 1582 (7.7) | 1432 (4.5) | 0.12 | 1523 (7.6) | 864 (5.5) | 0.015 |
HTA + CKD | 817 (4.0) | 1884 (5.9) | 0.1 | 764 (3.8) | 727 (4.7) | 0.074 |
DM | 640 (3.1) | 3344 (10.5) | 0.425 | 631 (3.2) | 818 (5.2) | 0.034 |
HTA + CKD + Dyslipidemia | 409 (2.0) | 1076 (3.4) | 0.1 | 403 (2.0) | 410 (2.6) | 0.044 |
HTA + DM + CKD | 290 (1.4) | 505 (1.6) | 0.015 | 282 (1.4) | 212 (1.4) | 0.002 |
HTA + DM + Dyslipidemia + CKD | 45 (0.2) | 213 (0.7) | 0.096 | 44 (0.2) | 74 (0.5) | 0.036 |
Cardiovascular risk factors, mean (SD) | ||||||
Systolic blood pressure (mmHg) | 127.1 (14.9) | 129.1 (17.2) | 0.134 | 127.1 (14.9) | 128.2 (16.3) | 0.07 |
Diastolic blood pressure (mmHg) | 80.2 (11) | 81.5 (12.1) | 0.12 | 80.3 (11) | 81 (12.2) | 0.054 |
Glycated hemoglobin (HbA1c) | 6.9 (1.8) | 8.4 (2.4) | 0.801 | 6.9 (1.7) | 7.2 (1.7) | 0.036 |
Total cholesterol (mg/dl) | 190.5 (40.9) | 201.2 (44.1) | 0.263 | 190.2 (40.4) | 194.1 (41.4) | 0.019 |
LDL cholesterol (mg/dl) | 109.7 (32.8) | 117.8 (33.3) | 0.247 | 109.8 (32.8) | 113.1 (31.7) | 0.016 |
HDL cholesterol (mg/dl) | 47.7 (11.1) | 47.6 (10.9) | 0.011 | 47.7 (11.1) | 47.6 (11) | 0.018 |
Triglycerides (mg/dl) | 153.1 (72.4) | 169.6 (79.4) | 0.229 | 152.3 (71.3) | 159.6 (72.2) | 0.045 |
Current smokingb | 1075 (5.2) | 8525 (26.7) | 0.968 | 1050 (5.3) | 1384 (8.9) | 0.006 |
Frequency of physical activity | ||||||
Never | 9172 (44.5) | 25,381 (79.6) | 0.706 | 9050 (45.4) | 11,196 (71.6) | 0.024 |
Occasional | 7396 (35.9) | 4350 (13.6) | 0.464 | 7098 (35.6) | 2868 (18.3) | 0.049 |
Frequent | 4045 (19.6) | 2163 (6.8) | 0.323 | 3795 (19.0) | 1567 (10.0) | 0.029 |