Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

Table 6 Multivariable-adjusted mean changes in fasting insulin & HOMA-IR (95% CI) over 6 years of follow-up, according to meeting guidelines for moderate-to-vigorous physical activity by Hispanic/Latino background – n ~ 7900^a

Change in CVD risk factors	MVPA guidelines^b		P	P of inter-action
Change in CVD risk factors	Not meet	Meet	P	P of inter-action
log Fasting insulin, mg/dl				0.01
Dominican	0.25 (0.15, 0.35)	0.07 (−0.03, 0.17)	0.006
Central American	0.21 (0.15, 0.27)	0.12 (0.02, 0.22)	0.59
Cuban	0.14 (0.06, 0.22)	0.06 (− 0.06, 0.18)	0.14
Mexican	0.23 (0.17, 0.29)	0.24 (0.18, 0.30)	0.68
Puerto Rican	0.19 (0.11, 0.27)	0.13 (0.05, 0.21)	0.25
South American	0.18 (0.10, 0.26)	0.10 (0.00, 0.20)	0.05
Mixed/other	0.25 (0.11, 0.39)	0.44 (0.24, 0.64)	0.09
log HOMA-IR				0.04
Dominican	0.29 (0.17, 0.41)	0.12 (0.02, 0.22)	0.03
Central American	0.24 (0.16, 0.32)	0.15 (0.03, 0.27)	0.73
Cuban	0.15 (0.07, 0.23)	0.07 (−0.05, 0.19)	0.13
Mexican	0.28 (0.22, 0.34)	0.29 (0.23, 0.35)	0.89
Puerto Rican	0.26 (0.16, 0.36)	0.18 (0.08, 0.28)	0.25
South American	0.21 (0.13, 0.29)	0.12 (0.00, 0.24)	0.08
Mixed/other	0.29 (0.13, 0.45)	0.52 (0.30, 0.74)	0.02

^aAll models adjusted for sex, use of medications that affect the dependent variable at baseline and/or visit2, baseline levels of the dependent variable, and elapsed time between visits, household income, education, employment status, Hispanic/Latino background, field center, and nativity status, smoking, alcohol consumption, health insurance status, healthcare utilization, self-reported health, diet quality (all assessed at baseline), change in health insurance coverage, BMI and waist-to-hip ratio. Significant findings p < 0.05 bolded
^bMeeting 2018 physical activity guidelines defined using measured activity scaled to 7 days of accelerometer wear as 150 minutes/week moderate intensity physical activity, 75 minutes/week vigorous intensity activity, or an equivalent combination of both

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