| Gastrointestinal disorders (failures = 229) | Other joint disorders (failures = 196) | Arthritis/osteoarthritis (failures = 113) | Hypertension (failures = 92) | Prostate and other genitourinary disease (failures = 65) | |
---|---|---|---|---|---|---|
CMD change | ||||||
 n (%) | Not a case stable | 137 (59.45%) | 132 (69.67%) | 74 (69.09%) | 55 (61.20%) | 39 (59.89%) |
 | Case stable | 29 (13.43%) | 24 (12.19%) | 14 (9.32%) | 11 (7.98%) | 12 (16.04%) |
 | Positive change | 32 (12.96%) | 20 (10.22%) | 11 (11.66%) | 14 (14.63%) | – |
 | Negative change | 29 (14.15%) | 15 (7.92%) | 10 (9.93%) | 11 (16.19%) | 9 (17.18%) |
Unadjusted HR (95% CI) | Not a case stable | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
 | Case stable | 1.93 (1.28–2.93) | 1.44 (0.91–2.28) | 1.55 (0.86–2.81) | 1.65 (0.83–3.29) | 2.11 (1.08–4.12) |
 | Positive change | 1.63 (1.09–2.43) | 1.00 (0.62–1.62) | 0.92 (0.48–1.78) | 1.82 (0.99–3.32) | – |
 | Negative change | 1.59 (1.05–2.42) | 0.75 (0.43–1.30) | 1.03 (0.53–2.02) | 1.53 (0.79–2.96) | 1.59 (0.76–3.34) |
Fully adjusted HR (95% CI) | Not a case stable | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
 | Case stable | 1.98 (1.28–3.08) | 1.37 (0.85–2.22) | 1.46 (0.76–2.79) | 1.56 (0.77–3.16) | 2.02 (1.06–3.83) |
 | Positive change | 1.65 (1.10–2.49) | 0.99 (0.60–1.64) | 1.03 (0.52–2.01) | 1.69 (0.89–3.21) | 0.47 (0.13–1.65) |
 | Negative change | 1.77 (1.16–2.69) | 0.70 (0.40–1.23) | 1.18 (0.59–2.37) | 1.62 (0.85–3.10) | 1.72 (0.81–3.68) |