Table 1 Primary and secondary outcomes with definitions

Primary Outcome

Definition

Confirmed HCV testing uptake

Participants that complete HCV testing as confirmed by medical records at HKU-SZH or other public facility in Shenzhen within 4 weeks of enrollment

Secondary Outcomes

Definitions

Self-reported HCV testing uptake

Participants that complete HCV testing within 4 weeks of enrollment, self-reported in follow-up survey

Followed-up for HCV confirmatory testing

Participants that follow-up with a provider at HKU-SZH for HCV RNA diagnostic testing, as confirmed by medical records at HKU-SZH or other public facility in Shenzhen

Self-reported follow-up for HCV confirmatory testing

Participants that follow-up with a provider at HKU-SZH or other care facilities in China for HCV RNA confirmatory testing, self-reported in follow-up survey

Initiated anti-HCV treatment

Participants that have a confirmed HCV diagnosis and initiate anti-HCV treatment at HKU-SZH Department of Gastroenterology, confirmed by medical records at HKU-SZH or other public facility in Shenzhen

Completed anti-HCV treatment

Participants that complete the full anti-HCV regiment, as confirmed by medical records at HKU-SZH

Diagnosed with chronic liver disease

Participants that are diagnosed with chronic liver disease including cirrhosis, advanced cirrhosis, or hepatocellular carcinoma at any point during the study, as confirmed by medical records at HKU-SZH

Followed-up with Liver Clinic for advanced chronic liver disease

Participants that are diagnosed with advanced chronic liver disease (i.e. advanced cirrhosis) and receive follow-up care at the Liver Clinic at HKU-SZH, as confirmed by medical records at HKU-SZH

Cured of HCV infection

Participants that achieve sustained virological response (SVR), defined as absence of detectable hepatitis C virus 12 weeks after completion of treatment, confirmed by medical records at HKU-SZH

Returned to primary care for future screening

Participants that returned to FMPC for services including regular HBV/HCV screening, HBV screening, HIV screening, other STI screening, as confirmed by medical records at HKU-SZH