Table 4 Subgroup analysis according to severity in osteoarthritis

1.45 (1.38–1.54)

1.38 (1.31–1.46)

1.05 (1.04–1.07)

14.4

0.16

2.00 (1.66–2.39)

1.92 (1.59–2.31)

1.04 (1.01–1.08)

5.8

0.29

1.86 (1.65–2.08)

1.65 (1.46–1.86)

1.13 (1.09–1.16)

19.5

0.17

1.93 (1.67–2.21)

1.72 (1.49–1.97)

1.12 (1.08–1.17)

18.2

0.19

2.10 (1.35–3.01)

1.77 (1.12–2.61)

1.19 (1.08–1.31)

23.4

0.45

1.29 (1.06–1.55)

1.28 (1.05–1.55)

1.01 (0.97–1.04)

2.5

0.53

1.61 (1.53–1.68)

1.52 (1.45–1.59)

1.06 (1.04–1.08)

11.8

0.81

2.64 (2.10–3.22)

2.50 (1.95–3.10)

1.06 (1.01–1.12)

6.1

0.10

2.59 (2.28–2.94)

2.21 (1.93–2.52)

1.17 (1.12–1.23)

17.5

0.32

2.74 (2.37–3.15)

2.33 (2.00–2.69)

1.18 (1.12–1.24)

16.7

0.78

3.04 (1.90–4.63)

2.38 (1.44–3.58)

1.28 (1.13–1.46)

23.7

0.20

1.54 (1.14–1.96)

1.52 (1.11–1.99)

1.01 (0.96–1.07)

3.3

0.42