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Table 2 Population characteristics of the studies included in the meta-analysis

From: Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

Study

# enrolled ZIKV+ pregnant women

# enrolled ZIKV+ newborns/fetuses

# ZIKV+ newborns/fetuses with microcephaly

Sex (male/total)

Maternal ethnicity (%)

Maternal age – mean (SD)

Microcephaly +

Microcephaly -

Microcephaly +

Microcephaly -

Aragão, MFVV et al. (2017) [26]

U*

19

16

 

Schaub, B et al. (2017) [27]

14

14

9

5/9

4/3

9/9

26.78 (6.33)

Krow-Lucal, ER et al. (2018) [28]

U*

115

43

 

Honein, M A et al. (2017) [29]

442

55

18

 

Kumar, M et al. (2016) [30]

4

4

3

1/3

0/1

3/3

1/1

27 (5.57)

Brasil, P et al. (2016) [31]

134

134

4

 

Pomar, L et al. (2017) [32]

301

278

28

15/28

126/250

27/28

244/250

28.08 (7.75)

Sanz Cortes, M et al. (2018) [33]

12

9

7

 

Shiu, C et al. (2018) [34]

8

87

5

 

Vargas, A et al. (2016) [35]

U*

40

40

20/43

5/14

12/43

2/14

23.5 (8)

França, G V A et al. **(2016) [36]

1501

602

330

244/567!

221/691!

495/567!

591/691!

24.79 (6.668)

Ventura, L O et al. (2017) [37]

U*

32

29

54/148

9/148

27.36 (7.28)

  1. * Unknown (not reported in the paper)
  2. ** All notified cases in different studies and areas of Brazil during this period are included in this study, i.e., data from Aragão et al., 2017 from December 2015 to February 2016; Krow-Lucal et al., 2018, from November 2015 to February 2016; Brazil et al., 2016, from November 2015 to February 2016; Ventura et al., 2017, November and December 2015