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Table 2 Characteristics of the studies (time-trend analysis) included in the meta-analysis

From: The quadrivalent HPV vaccine is protective against genital warts: a meta-analysis

First author (year)Study typeCountryYear of vaccine introductionProgramme descriptionPre-vaccination periodPost-vaccination periodPatient characteristics
age group + gender
Number of patients diagnosed with GW/ overall population
Pre-vaccination periodPost-vaccination period
Dominiak-Felden (2015) [17]time-trend analysisBelgium2007Reimbursed for:
• women 12 to 18 years old
2006–20072007–201316–22 years women244/6318012/24791
Chow (2015) [28]time-trend analysisAustralia2007School-based programme for:
• girls 12–13 years
Catch-up programmes (2007–2009) for:
• 13–18 years old schoolgirls
• 18–26 years old women
2004–20072007–2014Australian-born women < 21 years159/78774/1340
Australian-born women 21–32 years378/2801322/5662
Australian-born heterosexual men < 21 years62/531112/1531
Australian-born heterosexual men 21–32 years520/2726789/6539
Ali (2013) [27]time-trend analysisAustralia2007School-based programme for:
• girls 12–13 years
Catch-up programmes (2007–2009) for:
• 13–18 years old schoolgirls
• 18–26 years old women
2004–20072007–2011< 21 years women405/3949136/5456
21–30 years women942/7683407/7545
< 21 years heterosexual men132/128993/2693
21–30 years heterosexual men1195/66171034/8530
Harrison (2014) [29]time-trend analysisAustralia2007School-based programme for:
• girls 12–13 years
Catch-up programmes (2007–2009) for:
• 13–18 years old schoolgirls
• 18–26 years old women
2002–20062008–201215–27 years women189/4359671/42393
15–27 years men103/2115787/18745
Read (2011) [31]time-trend analysisAustralia2007School-based programme for:
• girls 12–13 years
Catch-up programmes (2007–2009) for:
• 13–18 years old schoolgirls
• 18–26 years old women
2004–20072007–2011< 21 years women168/88670/898
21–29 years women371/2808247/3546
< 21 years heterosexual men53/37845/445
21–29 years heterosexual men460/2524500/3479
Fairley (2009) [30]time-trend analysisAustralia2007School-based programme for:
• girls 12–13 years
Catch-up programmes (2007–2009 for:
• 13–18 years old schoolgirls
• 18–26 years old women
2004–20072008< 28 years women850/6693130/1970
all men2024/16727473/4778
Checchi (2019) [32]time-trend analysisEngland2012School-based programme for:
• girls 12–13 years
Catch-up programmes for:
• all females up to 18 years
2014201715–24 years females18,973/
3,341,260
13,170/
3,282,554
15–24 years heterosexual males15,981/
3,395,435
11,601/
3,356,744
Mann (2019) [33]time-trend analysisUSA2011School-based programme for:
• girls 11–12 years
• boys 11–12 years
Catch-up programmes for:
• girls up to 26 years
• boys up to 21 years (for bisexual, MSM up to 26 years)
20102016all females (median age: 26 years)973/42289193/21484
all males
(median age: 29 years)
3584/490971187/26983
  1. GW: genital wart, MSM: men who have sex with men