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Table 4 Parameter effects (with 95% CI) of Socio-demographics variables, risk variables, HR-QoL domain scores and clinical measurements on the transition intensities for the CD4 based Weibull multistate Markov model

From: Modelling immune deterioration, immune recovery and state-specific duration of HIV-infected women with viral load adjustment: using parametric multistate model

 Tran1: Normal to MildTran 2: Mild to AdvancedTran 3: Advanced to SevereTrans 4: Severe to AdvancedTrans 5: Advanced to MildTrans 6: Mild to Normal
Exp(β)
(95% CI)
Exp(β)
(95% CI)
Exp(β)
(95% CI)
Exp(β)
(95% CI)
Exp(β)
(95% CI)
Exp(β)
(95% CI)
Orthogonal Viral load1.62 (1.34, 1.91)***1.67 (1.39, 2.01)***2.10 (1.45, 3.04)**1.10 (0.78, 1.54)0.90 (0.77, 1.06)0.82 (0.70, 0.97)***
TB: Yes2.08 (1.02, 4.71)*1.52 (0.32, 7.29)1.86 (1.05, 4.61)*0.84 (0.59, 5.72)1.84 (0.41, 8.28)0.79 (0.47, 1.32)
Age_Cat: 18–20 years1.18 (0.72, 1.93)1.09 (0.68, 1.77)1.05 (0.53, 2.09)0.39 (0.16, 2.04)1.31 (0.88, 1.97)1.07 (0.68, 1.67)
Age_Cat: 21–39 years0.96 (0.56, 2.66)1.23 (0.64, 2.54)1.70 (0.06, 5.93)0.41 (0.16, 1.00)1.76 (0.71, 4.38)1.88 (0.95, 3.73)
Anemia: Yes1.23 (0.99, 1.52)1.31 (1.04, 1.66)**1.55 (0.92, 2.63)0.59 (0.36, 0.98)**0.94 (0.72, 1.24)0.79 (0.61, 1.03)
Education: Grade 9–100.34 (0.18, 0.63)**0.72 (0.40, 1.31)**1.07 (0.52, 2.20)1.11 (0.43, 2.91)1.08 (0.59, 1.96)1.20 (0.68, 2.11)
Education: Grade > 110.44 (0.25, 0.77)**0.51 (0.29, 0.87)*0.41 (0.23, 0.75)*1.41 (1.57, 3.49)0.91 (0.54, 1.52)1.41 (0.88, 2.27)
Marital Status: Married/stable sexual partners0.64 (0.32, 1.84)0.60 (0.38, 1.06)0.81 (0.34, 1.91)1.31 (1.01, 4.92)*1.10 (0.53, 1.97)1.01 (0.61, 1.44)
Marital Status: Single/no sexual partners0.58 (0.25, 3.88)0.64 (0.26, 1.60)0.63 (0.17, 2.29)1.27 (1.01, 2.70)*1.42 (0.37, 2.72)1.08 (0.42, 2.42)
Sex while Drunk: yes1.10 (0.72, 1.68)0.84 (0.42, 1.70)0.70 (0.29, 1.69)1.46 (0.71, 2.99)0.78 (0.44, 1.38)1.05 (0.57, 1.94)
RBC indices component0.98 (0.87, 1.10)0.83 (0.75, 1.91)0.93 (0.75, 1.15)0.88 (0.73, 1.06)0.92 (0.80, 1.05)1.16 (1.04, 1.30)***
Hb and Haematocrit component0.96 (0.86, 1.08)1.00 (0.89, 1.13)0.96 (0.78, 1.18)1.16 (0.97, 1.38)1.07 (0.94, 1.21)1.12 (1.01, 1.25)**
Granulocytes component0.91 (0.81, 1.03)0.85 (0.76, 0.96)**0.96 (0.78, 0.98)**1.10 (0.88, 1.37)1.18 (1.04, 1.34)*1.14 (1.02, 1.28)**
Mononuclear component0.77 (0.67, 0.88)**0.63 (0.55, 0.73)***0.64 (0.50, 0.83)**0.95 (0.73, 1.23)1.26 (1.13, 1.41)*1.42 (1.26, 1.60)***
Liver enzymes abnormality component0.94 (0.85, 1.05)0.98 (0.88, 1.09)1.05 (0.92, 1.21)1.19 (0.90, 1.58)0.86 (0.76, 0.98)*1.06 (0.94, 1.20)
Weight0.98 (0.97, 0.99)**0.98 (0.97, 0.99)**1.01 (0.99, 1.02)1.02 (0.99, 1.04)1.00 (0.99, 1.01)1.00 (0.99, 1.01)
Psychological well-being scores0.83 (0.76, 0.91)**0.91 (0.82, 0.99)*0.91 (0.78, 1.07)0.85 (0.68, 1.05)0.89 (0.82, 1.96)0.87 (0.80, 1.95)
Physical health scores1.21 (0.99, 1.33)1.05 (0.94, 1.17)1.03 (0.92, 1.17)1.25 (1.01, 1.58)**1.02 (0.96, 1.08)1.17 (1.07, 1.29)**
Independence Score0.87 (0.83, 0.91)*0.96 (0.92, 1.00)0.94 (0.88, 0.99)*1.00 (0.90, 1.10)1.01 (0.96, 1.05)1.04 (0.99, 1.09)
Social relationship0.96 (0.92, 0.99)*0.97 (0.93, 1.02)0.94 (0.86, 1.03)0.90 (0.82, 1.00)0.99 (0.95, 1.04)0.92 (0.87, 0.97)
  1. Key:- Statistical significance: (*)P < 0.05; (**)P < 0.01; (***)P < 0.001; reference category: Age [> 40]; education [Grade ≤ 8]; marital status [Many sexual partners]; TB [No]; Anemia [No]