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Table 4 Parameter effects (with 95% CI) of Socio-demographics variables, risk variables, HR-QoL domain scores and clinical measurements on the transition intensities for the CD4 based Weibull multistate Markov model

From: Modelling immune deterioration, immune recovery and state-specific duration of HIV-infected women with viral load adjustment: using parametric multistate model

 

Tran1: Normal to Mild

Tran 2: Mild to Advanced

Tran 3: Advanced to Severe

Trans 4: Severe to Advanced

Trans 5: Advanced to Mild

Trans 6: Mild to Normal

Exp(β)

(95% CI)

Exp(β)

(95% CI)

Exp(β)

(95% CI)

Exp(β)

(95% CI)

Exp(β)

(95% CI)

Exp(β)

(95% CI)

Orthogonal Viral load

1.62 (1.34, 1.91)***

1.67 (1.39, 2.01)***

2.10 (1.45, 3.04)**

1.10 (0.78, 1.54)

0.90 (0.77, 1.06)

0.82 (0.70, 0.97)***

TB: Yes

2.08 (1.02, 4.71)*

1.52 (0.32, 7.29)

1.86 (1.05, 4.61)*

0.84 (0.59, 5.72)

1.84 (0.41, 8.28)

0.79 (0.47, 1.32)

Age_Cat: 18–20 years

1.18 (0.72, 1.93)

1.09 (0.68, 1.77)

1.05 (0.53, 2.09)

0.39 (0.16, 2.04)

1.31 (0.88, 1.97)

1.07 (0.68, 1.67)

Age_Cat: 21–39 years

0.96 (0.56, 2.66)

1.23 (0.64, 2.54)

1.70 (0.06, 5.93)

0.41 (0.16, 1.00)

1.76 (0.71, 4.38)

1.88 (0.95, 3.73)

Anemia: Yes

1.23 (0.99, 1.52)

1.31 (1.04, 1.66)**

1.55 (0.92, 2.63)

0.59 (0.36, 0.98)**

0.94 (0.72, 1.24)

0.79 (0.61, 1.03)

Education: Grade 9–10

0.34 (0.18, 0.63)**

0.72 (0.40, 1.31)**

1.07 (0.52, 2.20)

1.11 (0.43, 2.91)

1.08 (0.59, 1.96)

1.20 (0.68, 2.11)

Education: Grade > 11

0.44 (0.25, 0.77)**

0.51 (0.29, 0.87)*

0.41 (0.23, 0.75)*

1.41 (1.57, 3.49)

0.91 (0.54, 1.52)

1.41 (0.88, 2.27)

Marital Status: Married/stable sexual partners

0.64 (0.32, 1.84)

0.60 (0.38, 1.06)

0.81 (0.34, 1.91)

1.31 (1.01, 4.92)*

1.10 (0.53, 1.97)

1.01 (0.61, 1.44)

Marital Status: Single/no sexual partners

0.58 (0.25, 3.88)

0.64 (0.26, 1.60)

0.63 (0.17, 2.29)

1.27 (1.01, 2.70)*

1.42 (0.37, 2.72)

1.08 (0.42, 2.42)

Sex while Drunk: yes

1.10 (0.72, 1.68)

0.84 (0.42, 1.70)

0.70 (0.29, 1.69)

1.46 (0.71, 2.99)

0.78 (0.44, 1.38)

1.05 (0.57, 1.94)

RBC indices component

0.98 (0.87, 1.10)

0.83 (0.75, 1.91)

0.93 (0.75, 1.15)

0.88 (0.73, 1.06)

0.92 (0.80, 1.05)

1.16 (1.04, 1.30)***

Hb and Haematocrit component

0.96 (0.86, 1.08)

1.00 (0.89, 1.13)

0.96 (0.78, 1.18)

1.16 (0.97, 1.38)

1.07 (0.94, 1.21)

1.12 (1.01, 1.25)**

Granulocytes component

0.91 (0.81, 1.03)

0.85 (0.76, 0.96)**

0.96 (0.78, 0.98)**

1.10 (0.88, 1.37)

1.18 (1.04, 1.34)*

1.14 (1.02, 1.28)**

Mononuclear component

0.77 (0.67, 0.88)**

0.63 (0.55, 0.73)***

0.64 (0.50, 0.83)**

0.95 (0.73, 1.23)

1.26 (1.13, 1.41)*

1.42 (1.26, 1.60)***

Liver enzymes abnormality component

0.94 (0.85, 1.05)

0.98 (0.88, 1.09)

1.05 (0.92, 1.21)

1.19 (0.90, 1.58)

0.86 (0.76, 0.98)*

1.06 (0.94, 1.20)

Weight

0.98 (0.97, 0.99)**

0.98 (0.97, 0.99)**

1.01 (0.99, 1.02)

1.02 (0.99, 1.04)

1.00 (0.99, 1.01)

1.00 (0.99, 1.01)

Psychological well-being scores

0.83 (0.76, 0.91)**

0.91 (0.82, 0.99)*

0.91 (0.78, 1.07)

0.85 (0.68, 1.05)

0.89 (0.82, 1.96)

0.87 (0.80, 1.95)

Physical health scores

1.21 (0.99, 1.33)

1.05 (0.94, 1.17)

1.03 (0.92, 1.17)

1.25 (1.01, 1.58)**

1.02 (0.96, 1.08)

1.17 (1.07, 1.29)**

Independence Score

0.87 (0.83, 0.91)*

0.96 (0.92, 1.00)

0.94 (0.88, 0.99)*

1.00 (0.90, 1.10)

1.01 (0.96, 1.05)

1.04 (0.99, 1.09)

Social relationship

0.96 (0.92, 0.99)*

0.97 (0.93, 1.02)

0.94 (0.86, 1.03)

0.90 (0.82, 1.00)

0.99 (0.95, 1.04)

0.92 (0.87, 0.97)

  1. Key:- Statistical significance: (*)P < 0.05; (**)P < 0.01; (***)P < 0.001; reference category: Age [> 40]; education [Grade ≤ 8]; marital status [Many sexual partners]; TB [No]; Anemia [No]
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