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Table 1 Adjusted hazard ratios of mortality and AIDS-defining event for all patients enrolled at time of data audit using the pre-audit and post-audit datasets

From: The impact of data quality and source data verification on epidemiologic inference: a practical application using HIV observational data

 

Mortality

AIDS-defining event

Pre-Audit Hazard Ratio

Post-Audit Hazard Ratio

Pre-Audit Hazard Ratio

Post-Audit Hazard Ratio

Gender

 Female

Ref

Ref

Ref

Ref

 Male

1.08 (0.96, 1.21)

1.04 (0.94, 1.15)

0.88 (0.74, 1.04)

0.93 (0.84, 1.04)

Age

 20

1.11 (0.87, 1.42)

1.08 (0.87, 1.33)

1.18 (0.90, 1.54)

1.06 (0.86, 1.31)

 30

0.92 (0.82, 1.03)

0.90 (0.82, 0.99)

1.05 (0.93, 1.19)

0.99 (0.89, 1.12)

 40

Ref

Ref

Ref

Ref

 50

1.30 (1.21, 1.40)

1.36 (1.29, 1.44)

0.97 (0.89, 1.05)

1.04 (0.94, 1.15)

 60

1.77 (1.49, 2.11)

1.96 (1.71, 2.26)

0.94 (0.76, 1.17)

1.09 (0.85, 1.39)

Clinical AIDS at baseline

 No

Ref

Ref

Ref

Ref

 Yes

2.07 (1.80, 2.39)

1.64 (1.46, 1.84)

7.55 (6.10, 9.34)

2.04 (1.40, 2.99)

Nadir CD4

 50

1.90 (1.59, 2.27)

1.96 (1.68, 2.28)

1.31 (1.02, 1.70)

1.87 (1.56, 2.25)

 100

1.46 (1.24, 1.73)

1.52 (1.32, 1.75)

1.17 (0.94, 1.46)

1.55 (1.32, 1.82)

 200

1.05 (0.92, 1.19)

1.11 (0.99, 1.23)

0.98 (0.86, 1.13)

1.14 (1.04, 1.24)

 350

Ref

Ref

Ref

Ref

Initiation Year

 2000

0.83 (0.70, 0.99)

0.91 (0.79, 1.06)

1.00 (0.83, 1.22)

1.15 (0.92, 1.43)

 2002

0.85 (0.74, 0.97)

1.01 (0.91, 1.13)

0.94 (0.79, 1.13)

1.08 (0.87, 1.34)

 2004

0.90 (0.82, 0.99)

1.05 (0.97, 1.13)

0.95 (0.87, 1.05)

1.02 (0.90, 1.17)

 2006

Ref

Ref

Ref

Ref

 2008

1.07 (1.00, 1.15)

0.98 (0.93, 1.04)

1.04 (0.94, 1.14)

1.04 (0.95, 1.14)

 2010

1.03 (0.84, 1.25)

1.08 (0.93, 1.26)

1.06 (0.85, 1.33)

1.15 (0.96, 1.39)

 2012

0.94 (0.62, 1.42)

1.27 (0.92, 1.74)

1.09 (0.74, 1.59)

1.30 (0.96, 1.77)

ARV CLASS

 NNRTI

Ref

Ref

Ref

Ref

 Boosted PI

1.30 (1.08, 1.55)

1.22 (1.04, 1.44)

1.05 (0.88, 1.25)

0.97 (0.83, 1.15)

 Other

1.11 (0.91, 1.37)

1.21 (1.02, 1.44)

0.99 (0.80, 1.24)

1.14 (0.88, 1.48)

IVDU

 No

Ref

Ref

Ref

Ref

 Yes

1.22 (0.81, 1.84)

1.56 (1.01, 2.40)

0.94 (0.70, 1.25)

1.11 (0.89, 1.39)